• Aging of hair follicle stem cells and their niches

    Scheme of the hair follicle structures during the hair cycle. The hair follicle goes through cycles of telogen (resting), anagen (growth), catagen (regression). HFSCs (light green) are found in the bulge and hair germ in telogen hair follicle. The sebaceous gland is located above the bulge and the dermal papilla (blue) is below the hair germ. In anagen hair follicle, the matrix is produced by the proliferation of the hair germ.
  • Current status and prospects of organoid-based regenerative medicine

    Definition of organoid. An organoid is in vitro miniaturized and simplified three-dimensional (3D) structure having multiple organ-specific cell types constituting the organ. For example, intestinal organoids are composed of enterocytes, Paneth ells, goblet cells, enteroendocrine cells and stem cells (Lgr5+ crypt base columnar cells), which constitute the actual intestinal epithelium. In addition, organoid have organ-like structures (e.g., crypt and villus structures in intestinal organoids) and mimic their specific functions (e.g., secretory and absorptive functions in intestinal organoids).
  • Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers

    Generation and applications of patient-derived tumor organoid (PDTO) from kidney or prostate cancer tissues. Kidney or prostate cancer tissues of patients are isolated, mechanically minced and then enzymatically digested. The dissociated cell suspension is strained to remove clumpy tissues, washed and embedded within matrigel to form organoids. To compare the diversity and similarity between in vivo tissues and organoids or to analyze a distinct inter-/intratumoral-heterogeneity at the genomic level, genomic/or transcriptomic analysis assessed a degree of variance or similarity of organoids corresponding parental tissues from cancer patients. Genome editing by using CRISPR Cas9 is employed in organoids. Prostate cancer or kidney cancer organoids can be used for preclinical models, such as anti-cancer drug screening, or biobanks.
  • Engineered human cardiac tissues for modeling heart diseases

    Cell components and engineering platforms for the development of cardiac tissue models. Several types of cardiac tissue models have been developed, to include various cardiac cells, using engineering platforms such as microwells, microfluidic devices, functional hydrogel, and bioprinting. This figure was created with BioRender.com.

BMB Reports 2023; 56(1): 1~48
Editorial
Stem cells, organoids and their applications for human diseases: Special issue of BMB Reports in 2023
Kunyoo Shin
BMB Reports 2023; 56(1): 1  https://doi.org/10.5483/BMBRep.2022-0210
Invited Mini Reviews
Aging of hair follicle stem cells and their niches
Hansaem Jang , Yemin Jo , Jung Hyun Lee & Sekyu Choi
BMB Reports 2023; 56(1): 2-9  https://doi.org/10.5483/BMBRep.2022-0183
Current status and prospects of organoid-based regenerative medicine
Woo Hee Choi , Dong Hyuck Bae & Jongman Yoo
BMB Reports 2023; 56(1): 10-14  https://doi.org/10.5483/BMBRep.2022-0195
Intestinal organoids as advanced modeling platforms to study the role of host-microbiome interaction in homeostasis and disease
Ji-Su Ahn, Min-Jung Kang, Yoojin Seo & Hyung-Sik Kim
BMB Reports 2023; 56(1): 15-23  https://doi.org/10.5483/BMBRep.2022-0182
Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers
Eunjeong Seo & Minyong Kang
BMB Reports 2023; 56(1): 24-31  https://doi.org/10.5483/BMBRep.2022-0200
Engineered human cardiac tissues for modeling heart diseases
Sungjin Min & Seung-Woo Cho
BMB Reports 2023; 56(1): 32-42  https://doi.org/10.5483/BMBRep.2022-0185
Development of bioinformatics and multi-omics analyses in organoids
Doyeon Ha , JungHo Kong , Donghyo Kim , Kwanghwan Lee , Juhun Lee , Minhyuk Park , Hyunsoo Ahn , Youngchul Oh & Sanguk Kim
BMB Reports 2023; 56(1): 43-48  https://doi.org/10.5483/BMBRep.2022-0155

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Current Issue

January 2023
Volume 56
Issue 1

2021 SCI Impact Factor 5.041

BIOCHEMISTRY & MOLECULAR BIOLOGY 98/298

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