• The trinity of ribosome-associated quality control and stress signaling for proteostasis and neuronal physiology

    An overview of the RQC pathway. (A, C) Ribosomal collisions occur when the preceding ribosome stalls during translation. In addition, stop-codon readthrough or endonucleolytic mRNA cleavage at the internally stalled ribosomes leads to 3’-end ribosome stalling. The collided ribosomes are detected by ribosome-associated collision sensors (e.g., ZNF598, EDF1). The cap-binding translation repressor complex of EIF4E2 and GIGYF2 is then recruited to the stalled ribosomes, blocking additional ribosome loading. (B, D) The RQT complex consisting of ASCC2 and ASCC3 likely senses ZNF598-dependent ubiquitination of specific ribosomal proteins (e.g., RPS10) at internally stalled ribosomes and triggers their disassembly. On the other hand, the PELO-HBS1L complex senses 3’-end ribosome stalling and recruits ABCE1 for the ribosome disassembly. (E) Nascent polypeptide chains associating with the 60S subunit undergo ubiquitindependent proteasomal degradation via three distinct pathways: 1) LTN1-dependent ubiquitination of the nascent chain for degradation (RQC-L); 2) NEMF-dependent C-terminal alanine/threonine (CAT)-tailing of the nascent chain, followed by RQC-L; and 3) NEMF-dependent alanine-tailing of the nascent chain, followed by the C-end rule pathway for protein degradation (RQC-C). Light and dark purple circles depict alanine and threonine residues, respectively, added to C-terminus of the nascent chain by NEMF activity. (F) The mRNAs are also degraded by exo- and endonucleases.
  • Emerging roles of PHLPP phosphatases in metabolism

    Domain architecture of PHLPP isoforms. PHLPP family retains the Ras association domain (RA), pleckstrin homology (PH) domain, leucine rich repeat region (LRR), PP2C domain and PDZ binding motif. Black arrow head denotes the splice site for PHLPP1β.

BMB Reports 2021; 54(9): 439~487
Invited Mini Reviews
The trinity of ribosome-associated quality control and stress signaling for proteostasis and neuronal physiology
Jumin Park , Jongmin Park, Jongbin Lee & Chunghun Lim
BMB Reports 2021; 54(9): 439-450  https://doi.org/10.5483/BMBRep.2021.54.9.097
Emerging roles of PHLPP phosphatases in metabolism
Jong-Ho Cha, Yelin Jeong, Ah-Reum Oh, Sang Bae Lee, Soon-Sun Hong & KyeongJin Kim
BMB Reports 2021; 54(9): 451-457  https://doi.org/10.5483/BMBRep.2021.54.9.095
Tat-CIAPIN1 protein prevents against cytokine-induced cytotoxicity in pancreatic RINm5F β-cells
Hyeon Ji Yeo, Min Jea Shin1, Dae Won Kim, Hyeok Yil Kwon, Won Sik Eum & Soo Young Choi
BMB Reports 2021; 54(9): 458-463  https://doi.org/10.5483/BMBRep.2021.54.9.040
Stage specific transcriptome profiles at cardiac lineage commitment during cardiomyocyte differentiation from mouse and human pluripotent stem cells
Sung Woo Cho, Hyoung Kyu Kim, Ji Hee Sung & Jin Han
BMB Reports 2021; 54(9): 464-469  https://doi.org/10.5483/BMBRep.2021.54.9.046
Low-dose metronomic doxorubicin inhibits mobilization and differentiation of endothelial progenitor cells through REDD1-mediated VEGFR-2 downregulation
Minsik Park, Ji Yoon Kim, Joohwan Kim, Jeong-Hyung Lee, Young-Guen Kwon & Young-Myeong Kim
BMB Reports 2021; 54(9): 470-475  https://doi.org/10.5483/BMBRep.2021.54.9.096
Perilipin 5 is a novel target of nuclear receptor LRH-1 to regulate hepatic triglycerides metabolism
Rubee Pantha, Jae-Ho Lee, Jae-Hoon Bae, Eun Hee Koh, Minsang Shin, Dae-Kyu Song & Seung-Soon Im
BMB Reports 2021; 54(9): 476-481  https://doi.org/10.5483/BMBRep.2021.54.9.051
IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-κB/NFATc1 signaling
Inyoung Kim, Jung Ha Kim, Kabsun Kim, Semun Seong, Keun-Bae Lee & Nacksung Kim
BMB Reports 2021; 54(9): 482-487  https://doi.org/10.5483/BMBRep.2021.54.9.070


Current Issue

September 2021
Volume 54
Issue 9

2020 SCI Impact Factor 4.778


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