• Emerging role of Hippo pathway in the regulation of hematopoiesis

    The Hippo pathway is a signaling pathway that regulates the self-renewal and differentiation of hematopoietic stem cells (HSCs). Mechanical stresses and the presence of VEGF activate the pathway, which promotes HSC retention in the bone marrow. MST1/2 and XMU-MP-1, respectively, suppress HSC expansion and ROS signaling. LATS1/2 and YAP/TAZ copolarize and form a complex in the cytosol with Scribble-Cdc42 GTPases, which controls HSC self-renewal and asymmetric cell division. Mechanical cyclic stretch influences embryonic aortic endothelial cell differentiation into HSCs by activating Rho GTPase, an upstream regulator of YAP-mediated mechanotransduction, which leads to RUNX1 expression for endothelial-hematopoietic transition (EHT).
  • Clinical features and molecular mechanism of muscle wasting in end stage renal disease

    Illustration showing multifactorial causes to induce muscle wasting in patients with end-stage renal disease. ESRD, end-stage renal disease.

BMB Reports 2023; 56(8): 417~468
Invited Mini Reviews
Emerging role of Hippo pathway in the regulation of hematopoiesis
Inyoung Kim , Taeho Park, Ji-Yoon Noh & Wantae Kim
BMB Reports 2023; 56(8): 417-425  https://doi.org/10.5483/BMBRep.2023-0094
Clinical features and molecular mechanism of muscle wasting in end stage renal disease
Sang Hyeon Ju & Hyon-Seung Yi
BMB Reports 2023; 56(8): 426-438  https://doi.org/10.5483/BMBRep.2023-0097
Articles
Regorafenib prevents the development of emphysema in a murine elastase model
Kwangseok Oh, Gun-Wu Lee, Han-Byeol Kim, Jin-Hee Park, Eun-Young Shin * & Eung-Gook Kim *
BMB Reports 2023; 56(8): 439-444  https://doi.org/10.5483/BMBRep.2023-0072
Hyaluronic acid and proteoglycan link protein 1 suppresses platelet-derived growth factor-BB-induced proliferation, migration, and phenotypic switching of vascular smooth muscle cells
Dan Zhou, Hae Chan Ha, Goowon Yang, Ji Min Jang, Bo Kyung Park, Zhicheng Fu, In Chul Shin & Dae Kyong Kim
BMB Reports 2023; 56(8): 445-450  https://doi.org/10.5483/BMBRep.2023-0088
USP14 inhibition regulates tumorigenesis by inducing apoptosis in gastric cancer
Mi Yea Lee, Min-Jee Kim, Jun-O Jin & Peter Chang-Whan Lee
BMB Reports 2023; 56(8): 451-456  https://doi.org/10.5483/BMBRep.2023-0063
Inhibition of glutathione S-transferase omega 1-catalyzed protein deglutathionylation suppresses adipocyte differentiation
Sana Iram, Areeba Mashaal, Seulgi Go & Jihoe Kim
BMB Reports 2023; 56(8): 457-462  https://doi.org/10.5483/BMBRep.2023-0038
Selection of iPSCs without mtDNA deletion for autologous cell therapy in a patient with Pearson syndrome
Yeonmi Lee, Jongsuk Han, Sae-Byeok Hwang, Soon-Suk Kang, Hyeoung-Bin Son, Chaeyeon Jin, Jae Eun Kim, Beom Hee Lee & Eunju Kang
BMB Reports 2023; 56(8): 463-468  https://doi.org/10.5483/BMBRep.2022-0204

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Current Issue

August 2023
Volume 56
Issue 8

2022 SCI Impact Factor 3.8

BIOCHEMISTRY & MOLECULAR BIOLOGY 134/285

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