• The role of NUMB/NUMB isoforms in cancer stem cells

    Asymmetric division of Drosophila neuroblasts. Schematic description for a polarized mother cell during anaphase. Asymmetric division of Drosophila neuroblasts produces larger neuroblasts and smaller ganglion mother cells (GMCs) (left panel). The middle panel shows the asymmetric distribution of polarity proteins at the apical and basal cortex and the asymmetry of the spindle. The light-blue box highlights evolutionarily conserved apical complexes that are important for polarity establishment and spindle positioning in these two systems. In the apical cortex, the Cdc42/Par3/Par6/aPKC complex is linked with the Gαi/Pins/Mud complex by Inscuteable. Mud recruit’s dynein-dynactin activity to capture and pull astral microtubules, whereas Pin recruits’ kinesin Khc73 via Dlg to bind with astral microtubules. Phosphorylation of Par6 by Aurora-A plays an important role in regulating aPKC to induce fate-determining proteins, such as Brat, Prospero, Staufen, and NUMB, to the basement membrane and future GMCs. Miranda is an adapter protein for some basic proteins.
  • Invited Mini Review  31 July 2021

    Mucin in cancer: a stealth cloak for cancer cells

    Mucins are high molecular-weight epithelial glycoproteins and are implicated in many physiological processes, including epithelial cell protection, signaling transduction, and tissue homeostasis. Abnormality of mucus expression and structure contributes to biological properties related to human cancer progression. Tumor growth sites induce inhospitable conditions. Many kinds of research suggest that mucins provide a microenvironment to avoid hypoxia, acidic, and other biological conditions that ...

  • Biomaterials-assisted spheroid engineering for regenerative therapy

    Differences between 2D monolayer culture and 3D spheroid culture for potential clinical applications.

BMB Reports 2021; 54(7): 335~391
Invited Mini Reviews
The role of NUMB/NUMB isoforms in cancer stem cells
Hye Yeon Choi, Jaekwon Seok , Geun-Ho Kang , Kyung Min Lim & Ssang-Goo Cho
BMB Reports 2021; 54(7): 335-343  https://doi.org/10.5483/BMBRep.2021.54.7.048
Mucin in cancer: a stealth cloak for cancer cells
Dong-Han Wi, Jong-Ho Cha & Youn-Sang Jung
BMB Reports 2021; 54(7): 344-355  https://doi.org/10.5483/BMBRep.2021.54.7.064
Biomaterials-assisted spheroid engineering for regenerative therapy
Na-Hyun Lee , Oyunchimeg Bayaraa , Zhou Zechu & Hye Sung Kim
BMB Reports 2021; 54(7): 356-367  https://doi.org/10.5483/BMBRep.2021.54.7.059
Articles
Expression profiles of human endogenous retrovirus (HERV)-K and HERV-R Env proteins in various cancers
Eun-Ji Ko , Kyoung Seob Song , Mee Sun Ock , Yung Hyun Choi , Suhkmann Kim , Heui-Soo Kim & Hee-Jae Cha
BMB Reports 2021; 54(7): 368-373  https://doi.org/10.5483/BMBRep.2021.54.7.246
Adipogenic function of tetranectin mediated by enhancing mitotic clonal expansion via ERK signaling
Seulgi Go, Jihyun Park, Safikur Rahman, Juno Jin, Inho Choi & Jihoe Kim
BMB Reports 2021; 54(7): 374-379  https://doi.org/10.5483/BMBRep.2021.54.7.024
Kinesin-1-dependent transport of the βPIX/GIT complex in neuronal cells
Eun-Young Shin , Chan-Soo Lee , Han-Byeol Kim, Jin-Hee Park, Kwangseok Oh, Gun-Wu Lee, Eun-Yul Cho, Hyong Kyu Kim & Eung-Gook Kim
BMB Reports 2021; 54(7): 380-385  https://doi.org/10.5483/BMBRep.2021.54.7.061
Paired analysis of tumor mutation burden calculated by targeted deep sequencing panel and whole exome sequencing in non-small cell lung cancer
Sehhoon Park , Chung Lee , Bo Mi Ku , Minjae Kim , Woong-Yang Park , Nayoung K. D. Kim & Myung-Ju Ahn
BMB Reports 2021; 54(7): 386-391  https://doi.org/10.5483/BMBRep.2021.54.7.045

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July 2021
Volume 54
Issue 7

2020 SCI Impact Factor 4.778

BIOCHEMISTRY & MOLECULAR BIOLOGY 98/298

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