• Coordination chemistry of mitochondrial copper metalloenzymes: exploring implications for copper dyshomeostasis in cell death

    Overview of mitochondrial cuproenzymes and copper chaperones. (A) Electron transport chain (complexes I–IV and ATP synthase) in the inner membrane of mitochondria. The complex IV renowned as cytochrome c oxidase (CcO) can reduce O2 into H2O, pumping proton from the matrix to the intermembrane space (IMS) to establish an electrochemical gradient for ATP synthesis. Mitochondrial SOD1 could detoxify superoxide anion (O2•−). Metallochaperones including Cox17, Sco1/2, Cox17, Cox11, and CCS mediate copper insertion into the cuproenzymes. (B) Coordination sphere of CuA site, heme a, and heme a3/CuB in CcO (PDB 5Z62). (C) Coordination sphere of Cox11 (PDB 1SO9).
  • Regulation of CMGC kinases by hypoxia

    Regulation of CMGC kinases by prolyl hydroxylation. The activation of DYRK1s, a group of CMGC kinases, critically relies on the autophosphorylation of a tyrosine residue within the activation loop of the catalytic domain. This essential autophosphorylation event takes place during the kinase’s folding process and is facilitated by a unique folding intermediate. Notably, this folding intermediate differs from the mature conformation that results from prolyl hydroxylation by PHDs.

BMB Reports 2023; 56(11): 575~623
Invited Mini Reviews
Coordination chemistry of mitochondrial copper metalloenzymes: exploring implications for copper dyshomeostasis in cell death
Daeun Shim & Jiyeon Han
BMB Reports 2023; 56(11): 575-583  https://doi.org/10.5483/BMBRep.2023-0172
Regulation of CMGC kinases by hypoxia
KyeongJin Kim & Sang Bae Lee
BMB Reports 2023; 56(11): 584-593  https://doi.org/10.5483/BMBRep.2023-0165
Articles
Discovering the anti-cancer phytochemical rutin against breast cancer through the methodical platform based on traditional medicinal knowledge
Jungwhoi Lee, Jungsul Lee, WooGwang Sim, Jae-Hoon Kim, Chulhee Choi & Jongwook Jeon
BMB Reports 2023; 56(11): 594-599  https://doi.org/10.5483/BMBRep.2023-0057
Regulation of glucose and glutamine metabolism to overcome cisplatin resistance in intrahepatic cholangiocarcinoma
So Mi Yang, Jueun Kim, Ji-Yeon Lee, Jung-Shin Lee & Ji Min Lee
BMB Reports 2023; 56(11): 600-605  https://doi.org/10.5483/BMBRep.2023-0029
The N-terminal peptide of the main protease of SARS-CoV-2, targeting dimer interface, inhibits its proteolytic activity
Sunyu Song, Yeseul Kim, Kiwoong Kwak, Hyeonmin Lee, Hyunjae Park, Young Bong Kim, Hee-Jung Lee & Lin-Woo Kang
BMB Reports 2023; 56(11): 606-611  https://doi.org/10.5483/BMBRep.2023-0153
Elevated level of PLRG1 is critical for the proliferation and maintenance of genome stability of tumor cells
Hyunji Choi , Moonkyung Kang, Kee-Ho Lee & Yeon-Soo Kim
BMB Reports 2023; 56(11): 612-617  https://doi.org/10.5483/BMBRep.2023-0162
Protein phosphatase 4 dephosphorylates phosphofructokinase-1 to regulate its enzymatic activity
Jaehong Park & Dong-Hyun Lee
BMB Reports 2023; 56(11): 618-623  https://doi.org/10.5483/BMBRep.2023-0065

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November 2023
Volume 56
Issue 11

2022 SCI Impact Factor 3.8

BIOCHEMISTRY & MOLECULAR BIOLOGY 134/285

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