• Advances in higher-order chromatin architecture: the move towards 4D genome

    An overview of hierarchical organization of eukaryotic genome. Genome is hierarchically packed into a tiny nucleus at different scales: chromosome territories, compartments, topologically associating domains (TADs), loop domains, and long-range enhancer-promoter contacts. Chromosomes occupy their own preferential location in the nucleus (multiple colors), referred to as territories. Each territory consists of two compartments: A and B. A compartment (light yellow) is composed of active epigenetic marks and actively transcribed genes, and associated with nuclear speckles (red circles). Repressive epigenetic marks and inactive genes constitute the B compartment (light blue), located close to the nuclear lamina (yellow and red wavy lines) and nucleolus (black circle). TADs are defined as highly self-interacting domains with the boundaries demarcated by CCCTC-binding factors (CTCFs) (light red) with cohesin complex (blue) (middle square). CTCF and cohesin (blue) play an important role in loop extrusion mechanism. At the finest scale of genome folding, long-range enhancer-promoter contacts are mediated by multiple different factors such as transcription factors (blue-green), YY1 (salmon), mediators (green), RNA polymerase II (pink) and non-coding RNAs (wavy brown lines) that promote contacts between cis-regulatory elements (CREs) (light yellow and orange square representing enhancer and promoter, respectively) (right square). The size of each scale ranges from 1 to 100 Mb for territories and compartments, 40 kb to 3 Mb for TADs and loop domains, and from 1 kb to few Mb for long-range enhancer-promoter contacts.
  • The Golgi complex: a hub of the secretory pathway

    Three models of protein transport within the Golgi complex. (A) Cisternal maturation model. Secretory cargo is transported in an anterograde direction along with cisternae maturation from cis-face to trans-face of the Golgi complex. Golgi resident proteins are transported in retrograde through COPI vesicles. (B) Rapid partitioning model. The Golgi stacks are distributed into two sub-domains. One is glycerophospholipids containing processing domain (white), while the other domain contains glycosphingolipids (black). Transmembrane secretory protein (green) are concentrated at export domain, while Golgi-resident proteins (red) are excluded from export domain and concentrated in processing domain. (C) Golgi tubule-mediated transport model. Each cisternae is connected by Golgi tubule which is regulated by the COPI complex. Golgi tubules are involve in the rapid bidirectional transport within the Golgi complex.

BMB Reports 2021; 54(5): 233~284
Invited Mini Reviews
Advances in higher-order chromatin architecture: the move towards 4D genome
Namyoung Jung & Tae-Kyung Kim
BMB Reports 2021; 54(5): 233-245  https://doi.org/10.5483/BMBRep.2021.54.5.035
The Golgi complex: a hub of the secretory pathway
Kunyou Park, Sungeun Ju, Nari Kim & Seung-Yeol Park
BMB Reports 2021; 54(5): 246-252  https://doi.org/10.5483/BMBRep.2021.54.5.270
Contributed Mini Review
The soma-germline communication: implications for somatic and reproductive aging
Matthew A. Gaddy , Swana Kuang, Mohammad A. Alfhili , & Myon Hee Lee
BMB Reports 2021; 54(5): 253-259  https://doi.org/10.5483/BMBRep.2021.54.5.198
Autophagy down-regulates NLRP3-dependent inflammatory response of intestinal epithelial cells under nutrient deprivation
Yewon Yun, Ahruem Baek & Dong-Eun Kim
BMB Reports 2021; 54(5): 260-265  https://doi.org/10.5483/BMBRep.2021.54.5.211
The estrogen-related receptor γ modulator, GSK5182, inhibits osteoclast differentiation and accelerates osteoclast apoptosis
Hyun-Ju Kim , Hye-Jin Yoon, Dong-Kyo Lee, Xian Jin, Xiangguo Che & Je-Yong Choi
BMB Reports 2021; 54(5): 266-271  https://doi.org/10.5483/BMBRep.2021.54.5.243
Phosphorylation of REPS1 at Ser709 by RSK attenuates the recycling of transferrin receptor
Seong Heon Kim, Jin-hwa Cho, Bi-Oh Park, Byoung Chul Park, Jeong-Hoon Kim, Sung Goo Park & Sunhong Kim
BMB Reports 2021; 54(5): 272-277  https://doi.org/10.5483/BMBRep.2021.54.5.266
Common and differential effects of docosahexaenoic acid and eicosapentaenoic acid on helper T-cell responses and associated pathways
Jaeho Lee , Yu Ri Choi , Miso Kim , Jung Mi Park , Moonjong Kang , Jaewon Oh , Chan Joo Lee , Sungha Park , Seok-Min Kang , Ichiro Manabe , Soo-jin Ann , & Sang-Hak Lee
BMB Reports 2021; 54(5): 278-283  https://doi.org/10.5483/BMBRep.2021.54.5.267
Erratum to: Biphasic effects of TGFβ1 on BMP9-induced osteogenic differentiation of mesenchymal stem cells
Rui-Dong Li, Zhong-Liang Deng, Ning Hu, Xi Liang, Bo Liu, Jinyong Luo, Liang Chen, Liangjun Yin, Xiaoji Luo, Wei Shui, Tong-Chuan He & Wei Huang
BMB Reports 2021; 54(5): 284-284  https://doi.org/10.5483/BMBRep.2021.54.5.053


Current Issue

May 2021
Volume 54
Issue 5

2019 SCI Impact Factor 3.167


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