Structures of all 12 G-protein coupled serotonin receptors. Cryo-EM maps of (A) 5-HT1 family: aripiprazole bound 5-HT_1A (PDB ID: 7E2Z), donitriptan bound 5-HT_1B (PDB ID: 6G79), 5-HT bound 5-HT_1D (PDB ID: 7E32), BRL-54443 bound 5-HT_1E (PDB ID: 7E33), Lasmiditan bound 5-HT_1F (PDB ID: 7EXD), (B) 5-HT₂ family: 25-CN-NBOH bound 5-HT_2A (PDB ID: 6WHA), LSD bound 5-HT_2B (PDB ID: 7SRR), LSD bound 5-HT_2B in complex with β-arrestin (PDB ID: 7SRS), Lorcaserin bound 5-HT_2C (PDB ID: 8DPI) and (C) 5-HT_4/5/6/7 family: 5-HT bound 5-HT₄ (PDB ID: 7XT8), 5-CT bound 5-HT₅ (PDB ID: 7UM5), 5-HT bound 5-HT₆ (PDB ID: 7XTB), and 5-CT bound 5-HT₇ (PDB ID: 7XTC).

DR effects in animals. DR prevents age-related diseases in various tissues including brain, heart, and muscle in animals and humans. Furthermore, DR increases the lifespan of animals. An impact of DR on longevity has not yet been confirmed in humans.