• Mass spectrometry-based approaches to explore metabolism regulating ferroptosis

    Fig. 1. Mass-spectrometry based analytical methods to study the role of metabolism in regulating ferroptosis. (A) The role of cysteine metabolism. Stable isotope-labeled serine and glutamine tracing approach are used to evaluate trans-sulfuration pathway and GCLC activity, respectively. The global metabolomics approach is used to analysis of γ-Glu-AAs. The cysteine and GSH is quantified after alkylating thiol group due to its high reactivity. (B) The role of radical-trapping antioxidant metabolism. CoQ10H2 and CoQ10 is quantified with an antioxidant to protect the auto-oxidation of CoQ10H2 during sample preparation and instrumental analysis. Also, the global metabolomics approaches are used to determine metabolic consequence of DHODH and GCH1 alteration, respectively. (C) The role of poly-unsaturated fatty acid metabolism. LC-MS/MS-based analysis including global lipidomics and targeted oxidized lipid analysis are applied to study role of poly-unsaturated lipid regulatory enzymes. RTA: radical-trapping antioxidant, (Cys)2: cystine, Cys: cysteine, Ser: serine, TSS: trans-sulfuration, Gln: Glutamine, GCLC: glutamate-cysteine ligase catalytic subunit, γ-Glu-Cys: γ-glutamyl-cysteine, GSH: glutathione, GSSG: oxidized glutathione, AAs: amino acids, γ-Glu-AAs: γ-glutamyl-amino acids, GPX4: glutathione peroxidase 4, PLOOH: phospholipid hydroperoxide, PLOH: phospholipid alcohol, PLOO・: phospholipid peroxyl radical, CoQ10: coenzyme Q10, CoQ10H2: dihydrocoenzyme Q10, FSP1: ferroptosis suppressor protein 1, DHODH: dihydroorotate dehydrogenase, BH4: tetrahydrobiopterin, BH2: dihydrobiopterin, GCH1: guanosine triphosphate cyclohydrolase 1, PUFA: poly-unsaturated fatty acid, PUFA-PLs: phospholipids containing polyunsaturated fatty acid, ASCL4: acyl-CoA synthetase long-chain family member 4, LPCAT3: lysophosphatidylcholine acyltransferase 3, LOX: lipoxygenase.
  • Systems pharmacology approaches in herbal medicine research: a brief review

    Fig. 1. Resources for network pharmacology in herbal medicine research. Left shows typical forms of an herb-compound-target network (blue edges) and herb-gene or compound-gene network (pink edges) used in network pharmacology research. Right shows public databases frequently utilized to construct networks for herbal medicine research.
  • Untold story of human cervical cancers: HPV-negative cervical cancer

    Fig. 1. Understudied HPV-negative cervical cancer. (A) PubMed search results indicate that the number of published works on HPV-negative cervical cancer (blue) is significantly lower than that on overall cervical cancer research (red). (B) The percentage of published work on HPV-negative cervical cancer (1.46%, right) is lower than the actual incidence rate of HPV-negative cervical cancers in the clinic (3-8%, left).

BMB Reports 2022; 55(9): 413~471
Invited Mini Reviews
Mass spectrometry-based approaches to explore metabolism regulating ferroptosis
Chi Thi Ngoc Nguyen , Seon Min Kim & Yun Pyo Kang
BMB Reports 2022; 55(9): 413-416  
Systems pharmacology approaches in herbal medicine research: a brief review
Myunggyo Lee, Hyejin Shin, Musun Park, Aeyung Kim, Seongwon Cha & Haeseung Lee
BMB Reports 2022; 55(9): 417-428  
Untold story of human cervical cancers: HPV-negative cervical cancer
Jae-Eun Lee, Yein Chung, Siyeon Rhee & Tae-Hyung Kim
BMB Reports 2022; 55(9): 429-438  
Contributed Mini Review
Conformational change of organic cofactor PLP is essential for catalysis in PLP-dependent enzymes
Ho-Phuong-Thuy Ngo, Diem Quynh Nguyen, Hyunjae Park, Yoon Sik Park, Kiwoong Kwak, Taejoon Kim, Jang Ho Lee, Kyoung Sang Cho & Lin-Woo Kang
BMB Reports 2022; 55(9): 439-446  
Articles
MiR-30a-5p and miR-153-3p regulate LPS-induced neuroinflammatory response and neuronal apoptosis by targeting NeuroD1
Hye-Rim Choi, Ji Sun Ha, Eun-A Kim, Sung-Woo Cho & Seung-Ju Yang
BMB Reports 2022; 55(9): 447-452  
Dysfunctional pancreatic cells differentiated from induced pluripotent stem cells with mitochondrial DNA mutations
Seongjun So, Song Lee, Yeonmi Lee, Jongsuk Han, Soonsuk Kang, Jiwan Choi, Bitnara Kim, Deokhoon Kim,
Hyun-Ju Yoo, In-Kyong Shim, Ju-Yun Oh, Yu-Na Lee, Song-Cheol Kim & Eunju Kang
BMB Reports 2022; 55(9): 453-458  
Melatonin inhibits glycolysis in hepatocellular carcinoma cells by downregulating mitochondrial respiration and mTORC1 activity
Seunghyeong Lee, Jun-Kyu Byun, Na-Young Kim, Jonghwa Jin , Hyein Woo, Yeon-Kyung Cho &
Keun-Gyu Park
BMB Reports 2022; 55(9): 459-464  
Establishment of the large-scale longitudinal multi-omics dataset in COVID-19 patients: data profile and biospecimen
Hye-Yeong Jo, Sang Cheol Kim, Do-hwan Ahn, Siyoung Lee, Se-Hyun Chang, So-Young Jung, Young-Jin Kim,
Eugene Kim, Jung-Eun Kim, Yeon-Sook Kim, Woong-Yang Park, Nam-Hyuk Cho, Donghyun Park, Ju-Hee Lee &
Hyun-Young Park
BMB Reports 2022; 55(9): 465-471  

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Current Issue

September 2022
Volume 55
Issue 9

2021 SCI Impact Factor 5.041

BIOCHEMISTRY & MOLECULAR BIOLOGY 98/298

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