• Potential role of ANGPTL4 in cancer progression, metastasis, and metabolism: a brief review

    Role of ANGPTL4 in cancer metastasis. ANGPTL4 plays a crucial role in various aspects of cancer metastasis. It promotes the growth of new blood vessels, which is pivotal to tumor nutrition and spread. It also influences cancer metastasis by impacting EMT and signaling pathways. Within the tumor microenvironment (TME), ANGPTL4 interacts with CAF, TAM, T-cell, and secretes MMP- and -9, influencing ECM remodeling, metastatic process, lymph node metastasis, and perineural invasion. flANGPTL4 and cANGPTL4 typically promote tumor growth and lung metastasis, whereas nANGPTL4 inhibits metastasis by reducing vascularity at metastatic sites.
  • Challenges and innovations in hematopoietic stem cell transplantation: exploring bone marrow niches and new model systems

    Hematopoietic niches in bone marrow. Organization and cellular interactions within the hematopoietic stem cell (HSC) niches of adult bone marrow (BM). HSCs are predominantly situated in proximity to the marrow vasculature, in perivascular niches. The niche includes various cell types, such as endothelial cells, CD169+ macrophages, and LepR+ CXCL12-abundant reticular (CAR) cells, dendritic cells (DCs), Nestin+ bone marrow stromal cells (BMSCs), and adipocytes. The niche contributes to HSC self-renewal, proliferation, and differentiation via the expression of CXCL12 and stem cell factor (SCF). Conversely, the endosteal niche houses quiescent HSCs, and is characterized by osteoblast, osteocyte, osteoclast, osteomac, and schwann cells, and megakaryocytes, which provide a specialized cellular architecture for hematopoiesis regulation and quiescence. The factors related to bone metabolisms and transforming growth factor beta-1 (TGF-β1), play a crucial role in the long-term persistence of quiescent HSCs. Various factors in the microenvironment, such as stiffness, calcium levels, oxygen gradients, and reactive oxygen species, help maintain the dormancy and quiescence of HSCs.

BMB Reports 2024; 57(9): 381~429
Invited Mini Reviews
Nuclear structures and their emerging roles in cell differentiation and development
Hye Ji Cha*
BMB Reports 2024; 57(9): 381-387  https://doi.org/10.5483/BMBRep.2024-0101
Metabolic reprogramming of the tumor microenvironment to enhance immunotherapy
Seon Ah Lim
BMB Reports 2024; 57(9): 388-399  https://doi.org/10.5483/BMBRep.2024-0031
Matricellular proteins in immunometabolism and tissue homeostasis
Kyoungjun Eun, Ah Young Kim & Seungjin Ryu
BMB Reports 2024; 57(9): 400-416  https://doi.org/10.5483/BMBRep.2023-0156
Articles
Glucose-dependent insulinotropic polypeptide (GIP) alleviates ferroptosis in aging-induced brain damage through the Epac/Rap1 signaling pathway
Jiwon Ko , Soyoung Jang, Soyeon Jang, Song Park, Junkoo Yi, Dong Kyu Choi, Seonggon Kim, Myoung Ok Kim, Su-Geun Lim & Zae Young Ryoo
BMB Reports 2024; 57(9): 417-423  https://doi.org/10.5483/BMBRep.2024-0067
Development of a highly effective recombinant protein from human collagen type III Alpha 1 (COL3A1) to enhance human skin cell functionality
Young Un Kim, HyunJoon Gi, Eun Kyung Jeong, Seokwon Han, Woo-Young Seo, Young Jun Kim, Sang Bae Lee & KyeongJin Kim
BMB Reports 2024; 57(9): 424-429  https://doi.org/10.5483/BMBRep.2024-0107

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Current Issue

September 2024
Volume 57
Issue 9

2023 SCI Impact Factor 2.9

BIOCHEMISTRY & MOLECULAR BIOLOGY 178/313

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