• The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages

    The schematics of immunomodulatory metabolites roles in shaping the inflammatory response of the macrophage. (A) The immunoregulatory functions of metabolites in macrophages upon pro-inflammatory stimulation (e.g., LPS/IFN-γ). LPS, lipopolysaccharide; IFN-γ, interferon-γ; NF-κB, nuclear factor-κB; TNF-α, tumor necrosis factor-α; IL-6, interleukin-6; IL-1β, interleukin-1β; PHD, prolyl hydroxylase; HIF-1α, hypoxia-inducible factor-1α; SDH, succinate dehydrogenase; IDH, isocitrate dehydrogenase; IRG1, immune-responsive gene 1; ACLY, ATP-citrate Lyase; PGE2, prostaglandin 2; H3K4me3, histone 3 lysine 4 tri-methylation; H3K27Ac, histone 3 lysine 27 acetylation; SUCNR1, succinate receptor 1; TFEB, transcription factor EB; Keap1, kelch-like ECH-associated protein 1; Nrf2, nuclear factor erythroid 2-related factor 2; ATF3, activating transcription factor 3; Rab32/BLOC3, Rab32/member RAS oncogene family 32/biogenesis of lysosomal organelles complex 1 subunit 3. (B) The immunoregulatory functions of metabolites in macrophages upon anti-inflammatory stimulation (e.g., IL-4/IL-13). IL-4, interleukin-4; IL-13, interleukin-13; FAO, fatty acid oxidation; PPAR-γ, peroxisome proliferator activated receptor-gamma; UDP-GluNAc, uridine diphosphate N-acetylglucosamine; ChREBP, carbohydrate response element binding protein; NADPH/NADP, nicotinamide-adenine dinucleotide phosphate reduced/nicotinamide-adenine dinucleotide phosphate oxidized; GPCR/PLC, G protein-coupled receptor/phospholipase C; H3K27me2, histone 3 lysine 4 di-methylation; JAK1/STAT6, janus kinase 1/Signal transducer and activator of transcription 6; ARG1, arginase 1; FIZZ1, found in inflammatory zone 1; MRC1, mannose receptor C-type 1. The red and blue color-coded components within the figures respectively represent the constituents of anti- and pro-inflammatory responses.
  • Structural basis of Ca2+ uptake by mitochondrial calcium uniporter in mitochondria: a brief review

    Overall architecture of Fungal MCU of N.crassa (37). (A) Each domains of N.crassa MCU are indicated (PDB code: 6DT0). Each protomer are colored separately. Missing part of N.crassa MCU structure are presented by black dashes. (B) Top view of N.crassa MCU structure. Ca2+ are represented by red spheres. Each TMH is marked in red letters at single protomer. (C) Bottom view of N.crassa MCU structure.
  • SUMO pathway is required for ribosome biogenesis

    Alignment of SUMO protein sequences and SUMO pathway diagram. (A) Sequence alignment of human SUMO-1 through SUMO-5 with yeast SUMO (Smt3) using Molecular Evolutionary Genetic Analysis software (MEGA, https://www.megasoftware.net/). Different letters and colors indicate different amino acids, and asterisks denote amino acids conserved among all SUMO proteins. (B) Diagram of the SUMOylation cycle. The precursor form of SUMO is processed by SENP proteases to create a mature form with a C-terminal Gly-Gly (GG) motif. Mature SUMO is ATP-dependent and activated by heterodimeric E1 SUMO-activating enzymes, SAE1 and SAE2, through a catalytic cysteine (C) residue in SAE2. Next, SUMO is transferred to the C residue of the E2 SUMO-conjugating enzyme (Ubc9), resulting in the conjugation of SUMO to the lysine (K) residues of the substrate protein with the aid of an E3 SUMO ligase. Finally, SENPs can deconjugate SUMO from the substrate or edit SUMO chains, after which SUMO is recycled through the conjugation event.

BMB Reports 2022; 55(11): 519~576
Invited Mini Reviews
The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages
Doyoung Park, Gyumin Lim, Sung-Jin Yoon , Hyon-Seung Yi & Dong Wook Choi
BMB Reports 2022; 55(11): 519-527  https://doi.org/10.5483/BMBRep.2022.55.11.128
Structural basis of Ca2+ uptake by mitochondrial calcium uniporter in mitochondria: a brief review
Jiho Yoo
BMB Reports 2022; 55(11): 528-534  https://doi.org/10.5483/BMBRep.2022.55.11.134
SUMO pathway is required for ribosome biogenesis
Hong-Yeoul Ryu
BMB Reports 2022; 55(11): 535-540  https://doi.org/10.5483/BMBRep.2022.55.11.130
Articles
SET7-mediated TIP60 methylation is essential for DNA double-strand break repair
Song Hyun Kim, Junyoung Park, Jin Woo Park, Ja Young Hahm, Seobin Yoon, In Jun Hwang, Keun Pil Kim & Sang-Beom Seo
BMB Reports 2022; 55(11): 541-546  https://doi.org/10.5483/BMBRep.2022.55.11.080
DN200434, an orally available inverse agonist of estrogen-related receptor γ, induces ferroptosis in sorafenib-resistant hepatocellular carcinoma
Dong-Ho Kim, Mi-Jin Kim, Na-Young Kim, Seunghyeong Lee, Jun-Kyu Byun, Jae Won Yun, Jaebon Lee, Jonghwa Jin, Jina Kim, Jungwook Chin, Sung Jin Cho, In-Kyu Lee, Yeon-Kyung Choi & Keun-Gyu Park
BMB Reports 2022; 55(11): 547-552  https://doi.org/10.5483/BMBRep.2022.55.11.089
Methylation-sensitive high-resolution melting analysis of the USP44 promoter can detect early-stage hepatocellular carcinoma in blood samples
Si-Cho Kim , Jiwon Kim, Da-Won Kim , Yanghee Choi, Kyunghyun Park, Eun Ju Cho , Su Jong Yu , Jeongsil Kim-Ha & Young-Joon Kim
BMB Reports 2022; 55(11): 553-558  https://doi.org/10.5483/BMBRep.2022.55.11.110
Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus
Yeong Chan Ryu, You-rin Kim, Jiyeon Park, Sehee Choi, Geon-Uk Kim, Eunhwan Kim, Yumi Hwang, Heejene Kim, Soon Sun Bak, Jin Eun Lee, Young Kwan Sung Gyoonhee Han, Soung-Hoon Lee & Kang-Yell Choi
BMB Reports 2022; 55(11): 559-564  https://doi.org/10.5483/BMBRep.2022.55.11.081
Crosstalk between BMP signaling and KCNK3 in phenotypic switching of pulmonary vascular smooth muscle cells
Yeongju Yeo, Hayoung Jeong, Minju Kim, Yanghee Choi, Koung Li Kim & Wonhee Suh
BMB Reports 2022; 55(11): 565-570  https://doi.org/10.5483/BMBRep.2022.55.11.098
Elevated plasma α1-antichymotrypsin is a biomarker candidate for malaria patients
Young Yil Bahk , Sang Bong Lee, Jong Bo Kim , Tong-Soo Kim , Sung-Jong Hong , Dong Min Kim & Sungkeun Lee
BMB Reports 2022; 55(11): 571-576  https://doi.org/10.5483/BMBRep.2022.55.11.126

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November 2022
Volume 55
Issue 11

2021 SCI Impact Factor 5.041

BIOCHEMISTRY & MOLECULAR BIOLOGY 98/298

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