BMB Reports 2022; 55(10): 481-487  https://doi.org/10.5483/BMBRep.2022.55.10.124
Function of gaseous hydrogen sulfide in liver fibrosis
Jae-Ho Lee & Seung-Soon Im*
Department of Physiology, Keimyung University School of Medicine, Daegu 42601, Korea
Correspondence to: Tel: +82-53-258-7423; Fax: +82-53-258-7412; E-mail: ssim73@kmu.ac.kr
Received: July 29, 2022; Revised: September 7, 2022; Accepted: September 21, 2022; Published online: October 31, 2022.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Over the past few years, hydrogen sulfide (H2S) has been shown to exert several biological functions in mammalian. The endogenous production of H2S is mainly mediated by cystathione β-synthase, cystathione γ-lyase and 3-mercaptopyruvate sulfur transferase. These enzymes are broadly expressed in liver tissue and regulates liver function by working on a variety of molecular targets. As an important regulator of liver function, H2S is critically involved in the pathogenesis of various liver diseases, such as non-alcoholic steatohepatitis and liver cancer. Targeting H2S-generating enzymes may be a therapeutic strategy for controlling liver diseases. This review described the function of H2S in liver disease and summarized recent characterized role of H2S in several cellular process of the liver.
Keywords: CBS, CSE, Hydrogen sulfide, Liver fibrosis, Metabolism, MPST
FIGURE
Fig. 1. Various cellular functions of H2S in in the liver. Three major enzymes responsible for H2S production are CBS, CSE, and MPST. L-cysteine is the major substrate for H2S production. H2S–mediated signaling varieties from protein modification by sulfidation to affecting a broad range of physiological processes, including regulation of mitochondrial biogenesis, glucose metabolism, oxidative stress, inflammation, fatty acid oxidation and crosstalk with other signaling molecules. CBS: cystathionine β-synthase; CSE: cystathionine γ-lyase; MPST: 3-mercaptopyruvate sulfur transferase.

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