Effects on tube formation, migration, and aortic ring in BCCM. (A) Wound healing assay was performed on HUVECs treated with CCM, BCCM and MMPP + BCCM to analyze their migratory ability. (B) The images of HUVECs tubes formation in CCM, BCCM and MMPP + BCCM were captured, and then the number of junctions was quantified by Image J. (C) The microvessels sprouts of mouse aortic rings were captured in the treatment of CCM, BCCM and MMPP + BCCM. Data are represented as the mean ± SD (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001 by one-way ANOVA. (D) Schematic diagram of anti-angiogenic effects of MMPP in endothelial cells. The figure was created using the Motfolio PPT Drawing Toolkits (motfolio.com).