Dynamics of cell cluster proportions revealed by scRNA-seq. (A) PCA plots considering genes significantly affected by the cell cycle (upper) or excluding them (lower). Cells were assigned to G1 phase (46.8%), G2/M phase (31.6%), and S phase (21.6%), respectively. The hidden heterogeneity is uncovered after excluding the cell cycle effect. (B) UMAP projections for control, 1W, and 2W cells. Four clusters (0-3) are identified using a resolution of 0.5. (C) Number of cells and the proportion of each cluster constituting control, 1W, and 2W cells, respectively.
