The Hippo pathway is involved in megakaryopoiesis (upper panel) and erythropoiesis (bottom panel). In megakaryopoiesis, YAP activity is elevated during endoreduplication. Although RhoA activity is reduced, LATS1/2 activity is unaffected. This uncoupling of RhoA and Hippo-p53 signaling is assumed to be essential for megakaryopoiesis (upper panel). YAP/TAZ are required for the maturation and enucleation of erythroblasts at late stages of erythropoiesis. However, they are unnecessary in the early stages (bottom panel).
