Schematic model regarding the importance of sarcopenia managements in progression of chronic kidney disease (CKD). As CKD progresses, compounded by dialysis duration and aging, muscle wasting leads an individual from a state of normality to pre-frailty and eventually, frailty. Improper management for muscle wasting can exacerbate the severity of sarcopenia and increase mortality rates. However, appropriate management could delay the progression of sarcopenia and lessen the associated mortality.