Inhibition of USP14 activity using the USP14 inhibitor IU1 or the inhibition of USP14 expression using USP14-specific siRNA decreases gastric cancer cell growth. (A) Effects of the inhibition of USP14 activity using IU1 (50 μM and 100 μM, left) or USP14 knockdown (right) on the viability of SNU216 cells (n = 3, *P < 0.05, **P < 0.01). (B) Effects of the inhibition of USP14 activity using IU1 (left) or USP14 knockdown (right) on the colony-forming ability of MKN74 and SNU216 cells (n = 3). (C) Effects of the inhibition of USP14 activity using IU1 (left) or USP14 knockdown (right) on the migration ability of MKN74 and SNU216 cells. Scale bar = 100 μm. (D) Effects of the inhibition of USP14 activity with IU1 (left) or USP14 knockdown (right) on wound healing ability of SNU216 cells (n = 3, *P < 0.05, **P < 0.01).
