The role of AGC2 in compartmentalization of aspartate and glutamate metabolism in the liver. Note that 2-OG produced in mitochondria by glutamate dehydrogenase and AST can be via the CAC converted to OA, the initial substrate for gluconeogenesis. 1, Amino acid transferase (2-OG dependent); 2, glutamate dehydrogenase; 3, AST mitochondrial; 4, glutaminase. AA, amino acids; AGC2, aspartate-glutamate carrier 2; ASP, aspartate; CAC, citric acid cycle; GC, glutamate carrier; GLU, glutamate; KA, keto acids; MAS, malate-aspartate shuttle; OGC, 2-oxoglutarate carrier; OA, oxaloacetate; UC, urea cycle; 2-OG, 2-oxoglutarate.
