The level of mtDNA deletions in the iPSC clones of PS patient. (A) Heteroplasmic level of patient-specific deletion in individual SiPSC clones. Three SiPSC clones (SiPS1, 9, and 12) had no deletions. (B) Heteroplasmic level of patient-specific deletion in individual BiPSC clones. All clones showed no deletion. (C) Average heteroplasmy of patient-specific deletion in SiPSCs and BiPSCs. The average heteroplasmy in the SiPSCs was 19%, while there was no mtDNA deletion in all the BiPSCs. (D) The heteroplasmy of other deletions, including the 4,977 bp common deletion in individual BiPSC clones. Five clones had no deletion. SiPSC: skin-derived iPSCs; BiPSCs: blood-derived iPSCs. Red boxes indicate the selected iPS clones for further studies.
