Generation of iPSCs derived from skin and blood in PS patient. (A) The schema for analyzing mtDNA deletion in iPSCs and iPSC-derived EB and teratoma. (B) Heteroplasmic level of patient-specific mtDNA deletion (mt8921-13316) in skin tissue and blood cells. Skin tissue and blood cells harbored 9% and 24% deletion, respectively. This result refers to Lee et al. (13). (C) Morphology of SiPSCs and BiPSCs. SiPSCs and BiPSCs displayed the typical morphology of human iPSCs. Scale bar: 100 nm.