PROM1 cell signaling in the liver. The first extracellular domain of PROM1 activates IL-6-STAT3 signaling pathway and hepatocyte proliferation by interacting with GP130 (14). The first intracellular domain of PROM1 inhibits TGFβ-SMAD2/3 signaling pathway and hepatocyte apoptosis by interacting with SMAD7 (13). The C-terminal cytoplasmic domain of PROM1 enhances glucagon-induced PKA signaling pathway and hepatic gluconeogenesis by interacting with Radixin (12).
