METTL14 depletion attenuates the initiative pathway of liver regeneration after PH. (A) Liver to body weight ratios at the indicated time points after PH in WT and HET mice (n = 4, each). (B) Serum ALT at the indicated time points after PH in WT and HET mice (n = 4, each). (C, D) HGF and TNF-α mRNA expression levels in the liver at the indicated time points after PH in WT and HET mice (n = 4, each). (E) Relative protein level of METTL14 in the liver at the indicated time points after PH in WT and HET mice (n = 3, each). (F) Representative western blot of METTL14, HGF, TGF-α and EGFR in the liver at the indicated time points after PH in WT and HET mice (n = 3, each). *P < 0.05, **P < 0.01 and ***P<0.001 when compared among time points in same group; #P < 0.05, ##P < 0.01 and ###P < 0.001 when compared between WT and HET mice; Error bar represents mean ± SD.
