Additional systemic overexpression of TM4SF5 in ApcMin/+ mice led to intramucosal adenocarcinomas in the intestines. We analyzed the intestines of ApcMin/+ (n = 4) or ApcMin/+:TgTM4SF5 (n = 6) mice at 26 weeks old using hematoxylin and eosin (H&E) staining. Tissues from two representative animals are shown separately in combined images (A, B). We quantified the pathological conditions (C).