The distinct role of PRC2/EZH2 and PRC2/EZH1 relies on their intrinsic properties. PRC2/EZH2 exhibits higher catalytic activity required for restoring H3K27 methylation after cell division. PRC2/EZH1 exhibits higher nucleosome binding activity which facilitates chromatin compaction and its maintenance at the post-developmental stage. Some images were created with BioRender.com.
