Human MCU-EMRE complex structure. (A) Top and side view of hMCU-EMRE complex structure (PDB code: 6O58) (41). The hMCU is marked as a gray and the hEMRE is colored by a cyan, and the red ball is Ca2+. (B) Side and bottom view of the pore region of hMCU-EMRE complex. Luminal gates are represented by red dashed box at side and bottom view. There is an enlarged figure of a luminal gate with labels of two resides (E288 and V290) which consists of luminal gate is at bottom view.