Type 17 and regulatory immunity and metabolism. (A) Meta-bolic control of type 17 and regulatory immune function. HIF-1α activation and/or glycolysis promotes Th17 and suppresses Treg differentiation. De novo fatty acid synthesis by ACC1 promotes Th17 and suppresses Treg differentiation. 2-hydroxyglutarate by GOT1 also promotes Th17 and suppresses Treg differentiation. (B) Type 17 and regulatory immune control of metabolic function. IL-17 promotes fatty acid synthesis in livers while suppressing adipogenesis. γδ T cells promotes adipose tissue thermogenesis. Treg also supports thermogenesis. Treg inhibits systemic insulin resistance and type 1 interferon can negate this function by depleting Treg.