Cox regression survival analysis of odorant receptor (OR) gene expression levels and somatic mutational profiling of OR genes in glioma. (A) A table describing univariate and multivariate Cox regression analysis of overall survival of OR genes in all glioma subtypes. Multivariate analysis was performed with age, IDH status, and histological grade. (B) A table describing OR genes that had expression levels significantly (P < 0.05 before P-value adjustment) associated with overall survival using the Cox proportional hazards regression model. An asterisk indicates the statistical significance after the P-value adjustment (P < 0.05). (C, D) A Kaplan–Meir survival curve showing the survival difference between the OR2C1/Olfr15-high group and the OR2C1/Olfr15-low group (C) or the OR51E1/Olfr558-high group and the OR51E1/Olfr558-low group (D). A high group represents samples with expression levels higher than the median expression level, and the remainder of the samples were assigned as the low group. (E) The mutational landscape of the 15 most mutated OR genes. The bottom bar indicates the glioma subtype, and the right bars indicate the number of samples harboring mutations in each OR gene. (F) The variant type distribution of somatic mutations of OR genes in glioma. (G) Bar plots showing the number of samples that have mutations in at least one OR gene and samples without OR mutations according to glioma subtype.