Effect of cisplatin on mitochondrial function in skeletal muscle. (A) GM levels. (B) ADP levels. (C) SUCC levels. (D) RCR levels. Values were determined by densitometric quantification and are shown as the mean ± standard error of the mean (SEM). Outliers in each group were excluded. CON, saline control; 0.1 mg, 0.1 mg/kg BW of cisplatin; and 0.5 mg, 0.5 mg/kg BW of cisplatin, administered in skeletal muscle. Statistical analysis was performed using one-way ANOVA with Tukey’s post-hoc test. BW, body weight. Units are arbitrary. *P < 0.05, **P < 0.01, ***P < 0.001 vs CON and #P < 0.05 vs 0.1 mg.