EGR1 mRNA expression is correlated to DUSP1, FOS, FOSB, CYR61, and JUN mRNA expression in BC. (A) Top 20 genes positively correlated with EGR1 mRNA expression based on 2, 136 BC samples in Curtis Breast (PMID: 22522925). Analysis was performed using Oncomine database. (B) The heat map of EGR1, DUSP1, FOSB, CYR61, and JUN mRNA expression across PAM50 BC subtypes in TCGA database. Data was analyzed using UCSC Xena (http://xena.ucsc.edu/). (C, D) Regression analysis showed that EGR1, DUSP1, and FOS had positively high correlation coefficients. Data was analyzed using UCSC Xena (http://xena.ucsc.edu/). (E) Data mining in bc-GenExMiner 4.0 confirmed the positive correlation between EGR1, DUSP1, FOSB, and JUN mRNA expression across DNA microarray data. (F, G) Regression analysis confirmed that EGR1, DUSP1, and FOS had positively high correlation coefficients across DNA microarray data. Data was analyzed using bc-GenExMiner 4.0 web. (H, I) The survival curve comparing the patient with high (red) and low (blue) expression of EGR1, DUSP1, FOS, FOSB, CYR61, and JUN was plotted from Kaplan Meier plotter in BC patients. The threshold of cox P-value < 0.05.
