Representations of higher-order chromatin organization. Hierarchical organization of chromatin is found in the cell nucleus. Each chromosome is positioned in spatially segregated regions called chromosome territories (CTs). Chromatin has two types of interactions, A compartment (red), and B compartment (blue). The A compartment is known have higher gene density, while the B compartment demonstrates lower gene density. Each compartment is composed of topologically associating domains (TADs), which are self-interacting chromatin regions. CCCTC-binding factor (CTCF) and cohesion complex bind to the TAD boundaries, and form chromatin looping structures.
