Cargo sorting and export regulated in the trans-Golgi network. Transport of cargoes to various destinations is regulated in the TGN. Many key factors have been identified. TGN export to endolysosome is regulated through Clathrin dependent and independent machineries. Mannose-6-phosphasphate receptor (M6PR) and Sortilin act as a cargo receptor in this pathway. In polarized cells, transport of apical and basolateral cargoes is regulated by multiple mechanisms that involve not only proteins, but also sugars.
