5-/12-lipoxygeneases play roles in HDM-induced TH2 cytokine synthesis. (A, B) Mice were intraperitoneally injected with MK886 or baicalein 1 h before every challenge. We collected BALF for ELISAs. (A) We analyzed the levels of LTB4 and 12(S)-HETE in BALF using ELISA. Data are shown as the mean ± SD (n = 5-7 per group). *P < 0.05, ***P < 0.001 versus the control group. (B) We analyzed the levels of IL-4, IL-5 and IL-13 in BALF using ELISA. Data are shown as the mean ± SD (n = 7-12 per group). ***P < 0.001 versus the negative (NC) or positive (DMSO) control group.