Type II ribosome-dependent endoribonuclease toxins. Structures of type II ribosome-dependent endoribonuclease toxins. Amino acid sequences for the toxin protein structures were from Escherichia coli strain K-12 and Proteus vulgaris (for HigB). Amino acid residues involved in general base/acid are indicated in light blue and key residues required for mRNA cleavage are indicated in yellow. (A) RelE monomer (PDB ID: 3KIX). (B) YoeB monomer (PDB ID: 6N90). (C) YafQ monomer (PDB ID: 4Q2U). (D) HigB monomer (PDB ID: 5IFG). (E) YhaV monomer (PDB ID: 2KHE). For comparison, RNase Sa from Streptomyces aureofaciens (F) and RNase T1 from Aspergillus oryzae (G) were used. (F) RNase Sa mono-mer (PDB ID: 1NLI). (G) RNase T1 monomer (PBD ID: 1I0V).