Functional Domains of Z-DNA/RNA binding proteins. The two Zα domain-containing ZBP1 establishes cell death by interaction with RIPK1 and RIPK3 via its RHIM domains. The ADAR1p150 isoform comprises a Zα domain, a nonfunctional Zβ, three RBD (dsRNA binding domain), and a deaminase domain that edits dsRNA. E3L from vaccinia virus has one Zα domain required for viral pathogenesis. PKZ is a fish kinase-recognizing Z-nucleic acid. The physiological role of Zα in all these Z-DNA/RNA sensing proteins is still largely unknown.