The LCCL domain is cleaved from the splenic cochlin and secreted into the blood during infection. Cochlin comprises the LCCL domain at the N-terminus and the two vWFA domains at the C-terminus. The follicular dendritic cells in the spleen and the lymph nodes produce and secrete cochlin in the extracellular matrix called a conduit. Here, the vWFA domains bind with the collagen cores of the conduits making cochlins to stock within the conduits. During infection, the LCCL domain is cleaved from the intact cochlin by aggrecanse 1 and secreted into the systemic circulation. The cleaved LCCL modulates innate immune response assisting bacterial clearance.
