Complementary relationship between whole-body imaging and IVM. Complementary relationship between MRI (whole-body imaging) and IVM. Tumor vessel leakage in the colon-cancer origin liver-metastasis model is evaluated by MRI and IVM. The combined use of whole-body imaging and IVM can complement the weakness of each imaging system and can generate synergistic effects. The white dotted rings and yellow triangles indicate increasing vessel leakage over time. Scale bar in MRI, 5 mm. Scale bar in IVM, 100 μm. RED in IVM data, RITC-dextran. Ktrans, transfer constant from the blood plasma into the extracellular extravascular space; Vp, fractional blood plasma volume; Ve, extracellular extravascular volume fraction.