Cisplatin treatment upregulates IL-6 and reduces miR-125a/let-7e expression in HUVECs. (A) IL-6 mRNA expression in response to cisplatin treatment (10 μM) in HUVECs. (B) Predicted target sequences of IL-6, IL-6R, and STAT3 3′UTRs targeted by miR-125a and let-7e, and mutated sequences for disrupting miR-125a and let-7e recognition sequences. (C) Quantitative PCR showing expression of miR-125a and let-7e in response to cisplatin treatment (10 μM) in HUVECs. *P < 0.05, ***P < 0.001 compared to controls. Error bars, s.e.m.
