Expression of related genes of U87 cells by treatment of exosomal miRNA-584 of transfected MSCs. (A) The data of RT-PCR indicate MMP-2 mRNA expression was significantly reduced in group treated with exosomes derived from miRNA-584 transfected MSCs. (B, C) Expression levels of related genes of U87 viability, growth and invasion were confirmed by western blot. Experiments were repeated three times. Columns, mean; bars, SE. (*P < 0.05).