Exercise combined with resveratrol supplementation improved whole-body glucose and lipid homeostasis in obese mice undergoing weight loss. Body weight loss (A) and daily food intake (B) were recorded during the body weight loss program. The selected tissue weights (C), intraperitoneal glucose tolerance test (GTT) (D), and levels of serum TG (E), TC (F), LDL-C (G), and HDL-C (H) were measured by enzymatic colorimetric methods after the four-week body weight loss program. The weight loss programs of the HFD-fed mice were performed as follows: control (Cont), exercise (Ex), resveratrol supplementation (Res), and exercise combined with resveratrol supplementation (Ex + Res). AUC indicates the total area under the GTT curve. The values represent mean ± SEM (n = 8). *P < 0.05, and **P < 0.01 vs. Cont group. Epididymal fat (epiWAT), quadriceps femoris muscle (QD), gastrocnemius muscle (GAS).