• Severe combined immunodeficiency pig as an emerging animal model for human diseases and regenerative medicines

    Defects in cytokine receptor signaling responsible for SCID phenotypes. (A) Most cytokine receptors are heterodimers or heterotrimers whose cytoplasmic regions are accompanied by JAK kinases which in turn activate STAT transcription factor. Proper functionality of these components leads to the development of normal and functional T, B, and NK cells. (B) Mutation in IL2RG inhibits the production of mature NK and T cells. (C) Mutations in JAK3 also prevent the development of mature NK and T cells. (D) Mutation in IL-7Rα chain affects only IL-7 signaling and blights T cell production (mutated molecules are shown with dashed outline).


BMB Reports 2019; 52(11): 625~670
Invited Mini Review
Severe combined immunodeficiency pig as an emerging animal model for human diseases and regenerative medicines
Muhammad Arsalan Iqbal, Kwonho Hong, Jin Hoi Kim & Youngsok Choi
BMB Reports 2019; 52(11): 625-634  https://doi.org/10.5483/BMBRep.2019.52.11.267
Articles
CpG-DNA induces bacteria-reactive IgM enhancing phagocytic activity against Staphylococcus aureus infection
Te Ha Kim, Dongbum Kim, Heesu Lee, Min Hyung Kwak, Sangkyu Park, Younghee Lee & Hyung-Joo Kwon
BMB Reports 2019; 52(11): 635-640  https://doi.org/10.5483/BMBRep.2019.52.11.018
RRM but not the Asp/Glu domain of hnRNP C1/C2 is required for splicing regulation of Ron exon 11 pre-mRNA
Heegyum Moon, Ha Na Jang, Yongchao Liu, Namjeong Choi, Jagyeong Oh, Jiyeon Ha, Hyeon Ho Kim, Xuexiu Zheng & Haihong Shen
BMB Reports 2019; 52(11): 641-646  https://doi.org/10.5483/BMBRep.2019.52.11.080
G protein-coupled estrogen receptor-1 agonist induces chemotherapeutic effect via ER stress signaling in gastric cancer
Seon-Jin Lee, Tae Woo Kim, Gyeong Lim Park, Yo Sep Hwang, Hee Jun Cho, Jong-Tae Kim & Hee Gu Lee
BMB Reports 2019; 52(11): 647-652  https://doi.org/10.5483/BMBRep.2019.52.11.007
Transgenic expression of rice MYB102 (OsMYB102) delays leaf senescence and decreases abiotic stress tolerance in Arabidopsis thaliana
Weilan Piao, Yasuhito Sakuraba & Nam-Chon Paek
BMB Reports 2019; 52(11): 653-658  https://doi.org/10.5483/BMBRep.2019.52.11.071
Vav1 inhibits RANKL-induced osteoclast differentiation and bone resorption
Jin Sun Jang, In Soon Kang, Young-Nam Cha, Zang Hee Lee, Mary C Dinauer, Young-June Kim & Chaekyun Kim
BMB Reports 2019; 52(11): 659-664  https://doi.org/10.5483/BMBRep.2019.52.11.013
Nucleotide-binding oligomerization domain protein 2 attenuates ER stress-induced cell death in vascular smooth muscle cells
Min-Young Kwon, Narae Hwang, Seon-Jin Lee & Su Wol Chung
BMB Reports 2019; 52(11): 665-670  https://doi.org/10.5483/BMBRep.2019.52.11.176

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November 2019
Volume 52
Issue 11

2018 SCI Impact Factor 2.966

BIOCHEMISTRY & MOLECULAR BIOLOGY 134/292

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