• Biological roles and an evolutionary sketch of the GRF-GIF transcriptional complex in plants

    Schematic summary of molecular and biological functions of the GRF-GIF duo. The core and common molecular features of the duo are depicted in the circle, in which the GRF-GIF duo associated with the SWI2/SNF2 complex performs transcriptional regulation of target genes, including its own (auto-activation), and miR396 post-transcriptionally represses GRF expression. The biological functions common to eudicots and monocots are shown in red, i.e., the promotion of leaf growth via the regulation of cell cycling and promotion of cell cycling in root meristematic zones; the biological functions confirmed in Arabidopsis and other eudicots are shown in green and black, respectively; the biological functions validated in rice and maize are shown in brown and blue, respectively. The solid arrows and block bars indicate experimentally verified promotive and inhibitory actions, respectively, while the dotted ones indicate speculated possibilities.
  • Proteolytic cleavages of MET: the divide-and-conquer strategy of a receptor tyrosine kinase

    The four described proteolytic cleavages of the MET receptor. (A) Presenilin-regulated intramembrane proteolysis (PS-RIP) of MET, involving sequential cleavage by ADAM metalloproteases and γ-secretase under steady-state conditions. These cleavages generate the extracellular fragment, MET-NTF (also named soluble MET, sMET) and the intracellular fragments, p55 MET (MET-CTF) and p50 MET (MET-ICD), degraded respectively by the lysosome and proteasome. This proteolytic process is involved in receptor half-life regulation. (B) Caspase cleavages of MET during apoptosis at the juxtamembrane ESVD1000 site and the C-terminal DNADDEVD1380 site, generating p40 METcaspase. This fragment can promote mitochondrial permeabilization and amplifies cell death. (C) MET cleavages during calcium-stress-induced necrosis, involving the first proteolysis by PS-RIP and a second by calcium-regulated calpains at the T1036 site, generating the intracellular p40 METcalpain fragment. (D) Calpain cleavage of MET promoted by high cell density and the R970C MET mutation. The generated intracellular p45 MET fragment can promote epithelial cell migration and invasion.
  • Disease model organism for Parkinson disease: Drosophila melanogaster

    Toxins and genetic factors responsible for PD. Schematic illustrations for related genes of PD and toxins in the mitochondria.

BMB Reports 2019; 52(4): 227~294
Invited Mini Reviews
Biological roles and an evolutionary sketch of the GRF-GIF transcriptional complex in plants
Jeong Hoe Kim
BMB Reports 2019; 52(4): 227-238  https://doi.org/10.5483/BMBRep.2019.52.4.051
Proteolytic cleavages of MET: the divide-and-conquer strategy of a receptor tyrosine kinase
Marie Fernandes, Leslie Duplaquet, and David Tulasne
BMB Reports 2019; 52(4): 239-249  https://doi.org/10.5483/BMBRep.2019.52.4.024
Contributed Mini Review
Disease model organism for Parkinson disease: Drosophila melanogaster
Binod Aryal, and Youngseok Lee
BMB Reports 2019; 52(4): 250-258  https://doi.org/10.5483/BMBRep.2019.52.4.204
Human umbilical cord blood plasma alleviates age-related olfactory dysfunction by attenuating peripheral TNF-α expression
Byung-Chul Lee, Insung Kang, Seung-Eun Lee, Jin Young Lee, Nari Shin, Jae-Jun Kim, Soon Won Choi & Kyung-Sun Kang
BMB Reports 2019; 52(4): 259-264  https://doi.org/10.5483/BMBRep.2019.52.4.124
Defect of SIRT1-FoxO3a axis is associated with the production of reactive oxygen species during protein kinase CK2 downregulation-mediated cellular senescence and nematode aging
Hye-Jun Ham, Jeong-Woo Park & Young-Seuk Bae
BMB Reports 2019; 52(4): 265-270  https://doi.org/10.5483/BMBRep.2019.52.4.156
Renal protective effects of zingerone in a mouse model of sepsis
Bong-Seon Lee, Changhun Lee, Sumin Yang, Sae-Kwang Ku & Jong-Sup Bae
BMB Reports 2019; 52(4): 271-276  https://doi.org/10.5483/BMBRep.2019.52.4.175
Insufficient radiofrequency ablation-induced autophagy contributes to the rapid progression of residual hepatocellular carcinoma through the HIF-1α/BNIP3 signaling pathway
Wen-Lei Xu, Shao-Hong Wang, Wen-Bing Sun, Jun Gao, Xue-Mei Ding, Jian Kong, Li Xu & Shan Ke
BMB Reports 2019; 52(4): 277-282  https://doi.org/10.5483/BMBRep.2019.52.4.263
Interleukin-2/antibody complex expanding Foxp3+ regulatory T cells exacerbates Th2-mediated allergic airway inflammation
Sung-Wook Hong, O Eunju, Jun Young Lee, Jaeu Yi, Kyungjin Cho, Juhee Kim, Daeun Kim, Charles D. Surh, and Kwang Soon Kim
BMB Reports 2019; 52(4): 283-288  https://doi.org/10.5483/BMBRep.2019.52.4.271
Ahnak-knockout mice show susceptibility to Bartonella henselae infection because of CD4+ T cell inactivation and decreased cytokine secretion
Eun Wha Choi, Hee Woo Lee, Jun Sik Lee, Il Yong Kim, Jae Hoon Shin & Je Kyung Seong
BMB Reports 2019; 52(4): 289-294  https://doi.org/10.5483/BMBRep.2019.52.4.310


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April 2019
Volume 52
Issue 4

2017 SCI Impact Factor 3.085


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