• The peripheral and central mechanisms underlying itch

    Fig. 1. Itch signaling pathway. Schematic illustrating the transmission of itch from the primary sensory neurons to the brain. Itch stimuli (pruritogens) activate itch-sensing neurons in the dorsal root ganglion (DRG) that innervate the skin, which then stimulate second-order neurons in the spinal cord and multiple brain regions. Indicated in the tables are pruritogens, itch-selective molecules and receptors expressed in the primary sensory neurons and spinal cord, and brain regions activated by cutaneous application of a pruritogen. STT, spinothalamic tract; SPA, spino-parabrachio-amygdaloid pathway; PFC, prefrontal cortex; SMA, supplementary motor area; PMC, premotor cortex; M1, primary motor cortex; S1, primary somatosensory cortex; S2, secondary somatosensory cortex; CC, cingulate cortex; IC, insular cortex; BG, basal ganglia; GRP, gastrin-releasing peptide; GRPR, gastrin-releasing peptide receptor; BNP, B-type natriuretic peptide; NPRA, natriuretic peptide receptor A; NK-1, neurokinin-1; H1, histamine H1 receptor; PLCβ3, phospholipase C β3; PLA2, phospholipase A2; 5-HT, 5-hydroxytryptamine (serotonin); 5-HT-2, 5-HT receptor subtype 2; PAR2, protease-activated receptor 2; Mrgpr, Mas-related G-protein-coupled receptor; ET-1, endothelin-1; ETA, endothelin-1 receptor A; BAM8-22, bovine adrenal medullary peptide 8-22.

BMB Rep. 2016; 49(9): 455~525
Simultaneous destabilization of β-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer
Pu-Hyeon Cha & Kang-Yell Choi,*
BMB Rep. 2016; 49(9): 455-456  
nArgBP2 as a hub molecule in the etiology of various neuropsychiatric disorders
Sang-Eun Lee & Sunghoe Chang*
BMB Rep. 2016; 49(9): 457-458  
Invited Mini Reviews
Precise assembly and regulation of 26S proteasome and correlation between proteasome dysfunction and neurodegenerative diseases
Eunju Im#,* & Kwang Chul Chung*
BMB Rep. 2016; 49(9): 459-473  
The peripheral and central mechanisms underlying itch
Jae Seung Lee#, Jasmin Sanghyun Han#, Kyeongho Lee, Juwon Bang & Hyosang Lee*
BMB Rep. 2016; 49(9): 474-487  
Extra-gonadal sites of estrogen biosynthesis and function
Radwa Barakat, Oliver Oakley, Heehyen Kim, Jooyoung Jin & CheMyong Jay Ko,*
BMB Rep. 2016; 49(9): 488-496  
Wide-line NMR and DSC studies on intrinsically disordered p53 transactivation domain and its helically pre-structured segment
Peter Tompa,#, Kyou-Hoon Han,#,*, Mónika Bokor, Pawel Kamasa, Ágnes Tantos, Beáta Fritz, Do-Hyoung Kim, Chewook Lee, Tamás Verebélyi & Kálmán Tompa,*
BMB Rep. 2016; 49(9): 497-501  
Tubeimoside-1 suppresses breast cancer metastasis through downregulation of CXCR4 chemokine receptor expression
Yaojin Peng, Yan Zhong & Gao Li,*
BMB Rep. 2016; 49(9): 502-507  
Suppression of Akt-HIF-1α signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis

Sik-Won Choi,#, Kwang-Sik Lee,#, Jin Hwan Lee, Hyeon Jung Kang, Mi Ja Lee, Hyun Young Kim, Kie-In Park, Sun-Lim Kim, Hye Kyoung Shin,* & Woo Duck Seo,*

BMB Rep. 2016; 49(9): 508-513  
Analysis of extended haplotype in Korean cattle (Hanwoo) population
Dajeong Lim, Bong Hwan Choi, Yong Min Cho, Han Ha Chai, Gul Won Jang, Cedric Gondro, Yeoung Ho Jeoung & Seung Hwan Lee,*
BMB Rep. 2016; 49(9): 514-519  
Promotion of formyl peptide receptor 1-mediated neutrophil chemotactic migration by antimicrobial peptides isolated from the centipede Scolopendra subspinipes mutilans
Yoo Jung Park, Sung Kyun Lee, Young Su Jung, Mingyu Lee, Ha Young Lee, Sang Doo Kim, Joon Seong Park, JaeHyung Koo, Jae Sam Hwang & Yoe-Sik Bae,*
BMB Rep. 2016; 49(9): 520-525  


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September 2016
Volume 49
Issue 9

2015 SCI Impact Factor 2.782


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