• New insight into transglutaminase 2 and link to neurodegenerative diseases

    Structure and two differential state of TG2 activity. (a, b) Two distinct protein structures of TG2 are depicted. Calcium-bound active structure of TG2 (open form; a) and its GDP-bound inactive structure in the absence of calcium (closed form; b). Through these calcium-dependent conformational changes, TG2 activity is reversibly changed. (c, d) The open structure of TG2 has the functions of transamidation and protein disulfide isomerase, whereas its closed form displays the functions of protein disulfide isomerase, GTPase, and protein kinase. (e) The detailed chemical reactions mediated by TG2, such as the cross-linking, deamination, amine incorporation, and GTPase activities, and the structural changes of target proteins are described.
  • Integration of metabolomics and transcriptomics in nanotoxicity studies

    Summary diagram comparing conventional methods and metabotranscriptomics approach for the assessment of MNPs@SiO2(RITC)-induced nanotoxicity (, –). MNPs: MNPs@SiO2(RITC), IP: Intraperitoneal, TEM: transmission electron microscopy.

BMB Reports 2018; 51(1): 1~53
Perspectives
Prevalence of negative frequency-dependent selection, revealed by incomplete selective sweeps in African populations of Drosophila melanogaster
Yuseob Kim
BMB Reports 2018; 51(1): 1-2  https://doi.org/10.5483/BMBRep.2018.51.1.226
Rebound excitability mediates motor abnormalities in Parkinson’s disease
Jeongjin Kim, and Daesoo Kim
BMB Reports 2018; 51(1): 3-4  https://doi.org/10.5483/BMBRep.2018.51.1.004
Invited Mini Reviews
New insight into transglutaminase 2 and link to neurodegenerative diseases
Boram Min, and Kwang Chul Chung
BMB Reports 2018; 51(1): 5-13  https://doi.org/10.5483/BMBRep.2018.51.1.227
Integration of metabolomics and transcriptomics in nanotoxicity studies
Tae Hwan Shin, Da Yeon Lee, Hyeon-Seong Lee, Hyung Jin Park, Moon Suk Jin, Man-Jeong Paik, Balachandran Manavalan, Jung-Soon Mo, and Gwang Lee
BMB Reports 2018; 51(1): 14-20  https://doi.org/10.5483/BMBRep.2018.51.1.237
Articles
LDB2 regulates the expression of DLL4 through the formation of oligomeric complexes in endothelial cells
Hyun-Jung Choi, Seung-Sik Rho, Dong-Hoon Choi, and Young-Guen Kwon
BMB Reports 2018; 51(1): 21-26  https://doi.org/10.5483/BMBRep.2018.51.1.140
Dual effects of a CpG-DNAzyme targeting mutant EGFR transcripts in lung cancer cells: TLR9 activation and EGFR downregulation
Dahye Jang, Yu Mi Baek, Hanna Park, Yeo Eun Hwang, and Dong-Eun Kim
BMB Reports 2018; 51(1): 27-32  https://doi.org/10.5483/BMBRep.2018.51.1.163
HCBP6 upregulates human SREBP1c expression by binding to C/EBPβ-binding site in the SREBP1c promoter
Xueliang Yang, Ming Han, Shunai Liu, Xiaoxue Yuan, Xiaojing Liu, Shenghu Feng, Li Zhou, Yaru Li, Hongping Lu, Jun Cheng, and Shumei Lin
BMB Reports 2018; 51(1): 33-38  https://doi.org/10.5483/BMBRep.2018.51.1.184
Epac2a-knockout mice are resistant to dexamethasone-induced skeletal muscle atrophy and short-term cold stress
Seung-Eun Song, Su-Kyung Shin, So-Young Park, Il-Seon Hwang, Seung-Soon Im, Jae-Hoon Bae, Myung-Sook Choi, and Dae-Kyu Song
BMB Reports 2018; 51(1): 39-44  https://doi.org/10.5483/BMBRep.2018.51.1.132
Erratum
Erratum to: Upstream signalling of mTORC1 and its hyperactivation in type 2 diabetes (T2D)
Muhammad Ali, Shazia Anwer Bukhari, Muhammad Ali & Han-Woong Lee
BMB Reports 2018; 51(1): 45-53  

e-submission

Current Issue

January 2018
Volume 51
Issue 1

2016 SCI Impact Factor 3.089

BIOCHEMISTRY & MOLECULAR BIOLOGY 138/289

Indexed/Covered by

Supported By