• The cellular basis of dendrite pathology in neurodegenerative diseases

    Localization of dendritic cellular components in Drosophila melanogaster dorsal cluster dendritic arborization (da) neurons. Merged images of local cellular components (green, marked by arrowheads) with membrane marker protein, CD4-tdTOM (red). Dendritic distribution of microtubules labeled by Tau-GFP (A), F-actin labeled by GMA (B), GOPs labeled by galT-eGFP (C), and mitochondria labeled by Mito-GFP (D), was examined in dorsal cluster da neurons by using 109(2)80-Gal4 driver. Dendrite images of da neurons of Drosophila 3rd instar larva located in abdominal segments A2 to A4 were captured using confocal microscopy. Scale bar indicates 50 μm.
  • Databases and tools for constructing signal transduction networks in cancer

    Systems biology, databases, and network generation. (A) The diversity of types of high-throughput data (genomics, epigenomics, transcriptomics, proteomics, metabolomics) available. The relationships among the data types are connected by edges. (B) The flow (represented by “edges”) of genetic information from DNA to protein is aligned with the diverse data types. Public repositories corresponding to each data type are listed (further description in ). (C) Network differences between correlation-based approaches and Bayesian networks approaches. The correlation (or mutual information) oriented tools, ARACNE () and WGCNA (), do not report directions of edges in networks. Bayesian-driven networks naturally reveal directed edges among the network entries. In other words, the undirected network (in left of the grey-shaded triangular) having G1, G2, and G3 entries by ARACNE and WGCNA can be differentiated into directed networks (in the right of the grey-shaded triangular), using Bayesian networks tools (–).
  • CRISPR as a strong gene editing tool

    How does CRISPR system correctly cut target DNA? (left panel) The Procedures of producing crRNA from pre-crRNA, binding of cr-RNA:tracrRNA: Cas9 complex to the target sequence near the PAM and the cleavage of target DNA are described. (right panel) The components of figures are described at right panel.

BMB Reports 2017; 50(1): 1~54
Perspectives
Interacting network of Hippo, Wnt/β-catenin and Notch signaling represses liver tumor formation
Wantae Kim, Sanjoy Kumar Khan, and Yingzi Yang
BMB Reports 2017; 50(1): 1-2  https://doi.org/10.5483/BMBRep.2017.50.1.196
Perspectives provided by leopard and other cat genomes: how diet determined the evolutionary history of carnivores, omnivores, and herbivores
Soonok Kim, Yun Sung Cho, Jong Bhak, Stephen J. O’Brian, and Joo-Hong Yeo
BMB Reports 2017; 50(1): 3-4  https://doi.org/10.5483/BMBRep.2017.50.1.002
Invited Mini Reviews
The cellular basis of dendrite pathology in neurodegenerative diseases
Jung Hyun Kweon, Sunhong Kim, and Sung Bae Lee
BMB Reports 2017; 50(1): 5-11  https://doi.org/10.5483/BMBRep.2017.50.1.131
Databases and tools for constructing signal transduction networks in cancer
Seungyoon Nam
BMB Reports 2017; 50(1): 12-19  https://doi.org/10.5483/BMBRep.2017.50.1.135
Contributed Mini Review
CRISPR as a strong gene editing tool
Shengfu Shen, Tiing Jen Loh, Hongling Shen, Xuexiu Zheng, and Haihong Shen
BMB Reports 2017; 50(1): 20-24  https://doi.org/10.5483/BMBRep.2017.50.1.128
Articles
Celastrol suppresses expression of adhesion molecules and chemokines by inhibiting JNK-STAT1/NF-κB activation in poly(I:C)-stimulated astrocytes
Soo Yeon An, Gi Soo Youn, Hyejin Kim, Soo Young Choi, and Jinseu Park
BMB Reports 2017; 50(1): 25-30  https://doi.org/10.5483/BMBRep.2017.50.1.114
Caffeine-induced food-avoidance behavior is mediated by neuroendocrine signals in Caenorhabditis elegans
Hyemin Min, Esther Youn, Ichiro Kawasaki, and Yhong-Hee Shim
BMB Reports 2017; 50(1): 31-36  https://doi.org/10.5483/BMBRep.2017.50.1.126
C-terminally mutated tubby protein accumulates in aggresomes
Sunshin Kim, Ho Jin Sung, Ji Won Lee, Yun Hee Kim, Yong-Seok Oh, Kyong-Ah Yoon, Kyun Heo, and Pann-Ghill Suh
BMB Reports 2017; 50(1): 37-42  https://doi.org/10.5483/BMBRep.2017.50.1.140
Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice
Ok-Hee Kim, Hyojung Kim, Jinku Kang, Dongki Yang, Yu-Hoi Kang, Dae Ho Lee, Gi Jeong Cheon, Sang Chul Park, and Byung-Chul Oh
BMB Reports 2017; 50(1): 43-48  https://doi.org/10.5483/BMBRep.2017.50.1.167
Vitamin C enhances the expression of IL17 in a Jmjd2–dependent manner
Mi Hye Song, Varun Sasidharan Nair, and Kwon Ik Oh
BMB Reports 2017; 50(1): 49-54  https://doi.org/10.5483/BMBRep.2017.50.1.193

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January 2017
Volume 50
Issue 1

2015 SCI Impact Factor 2.782

BIOCHEMISTRY & MOLECULAR BIOLOGY 138/289

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