• Mitochondrial noncoding RNA transport

    Schematic of the ncRNAs transported through the mitochondrial outer and inner membranes (OM, IM). Left, ncRNAs synthesized in mitochondria but found elsewhere (nucleus and extracellular space); right, ncRNAs synthesized in the nucleus and found in mitochondria, including tRNAs, 5S rRNA, lncRNAs like RMRP, and microRNAs and their precursors. Transport factors identified as mediators of these processes, including many ncRNA-interacting RBPs, are indicated. Yellow, nucleus; gray, cytoplasm; blue, mitochondria; pink, extracellular space.
  • Nonsense-mediated mRNA decay at the crossroads of many cellular pathways

    Models of NMD activation. (A) The EJC-dependent model. PTCs are recognized if they are present more than 50–55 nucleotides upstream of an exon-exon junction during the pioneer round of translation. The mRNA carries the CBP20/CBP80 hetero-dimer at the 5′cap and PABPN1 and PABPC1 on the poly(A) tail at the 3′ end. In this model UPF1 is recruited by the UPF3X and UPF2 proteins bound to the exon junction complex (EJC). Translation termination occurs because UPF1 interacts with the release factors eRF1 () and eRF3 (). (B) The PTC-PABPC1 distance model. PTC recognition is based on the probability that translation termination will occur via the interaction between UPF1 and release factors (NMD translation termination) or via the interaction between PABPC1 and release factors (normal translation termination).
  • Translation initiation mediated by nuclear cap-binding protein complex

    Mechanistic comparison of CBC-dependent translation (CT) and eIF4E-dependent translation (ET). The details are described in the text.
  • Translational control of mRNAs by 3′-Untranslated region binding proteins

    mRNA processing generates 3′-UTR variants. (A) Schematic depictions of pre-mRNA and mature mRNA. UTR (untranslated region), CDS (protein coding sequence), UC-PAS (upstream core polyadenylation signal), DC-PAS (downstream core polyadenylation signal). (B) mRNA isoforms with alternative poly(A) additions.

BMB Reports 2017; 50(4): 157~231
Editorial
RNA at the heart of gene expression: Special issue of BMB Reports 2017
Yoon Ki Kim
BMB Reports 2017; 50(4): 157-157  https://doi.org/10.5483/BMBRep.2017.50.4.046
Perspectives
Non-canonical targets play an important role in microRNA stability control mechanisms
June Hyun Park, and Chanseok Shin
BMB Reports 2017; 50(4): 158-159  https://doi.org/10.5483/BMBRep.2017.50.4.029
Longevity regulation by NMD-mediated mRNA quality control
Heehwa G. Son, and Seung-Jae V. Lee
BMB Reports 2017; 50(4): 160-161  https://doi.org/10.5483/BMBRep.2017.50.4.045
Fine-tuning of gene expression dynamics by the Set2-Rpd3S pathway
Bo Bae Lee, Ji Hyun Kim, and TaeSoo Kim
BMB Reports 2017; 50(4): 162-163  https://doi.org/10.5483/BMBRep.2017.50.4.049
Invited Mini Reviews
Mitochondrial noncoding RNA transport
Kyoung Mi Kim, Ji Heon Noh, Kotb Abdelmohsen, and Myriam Gorospe
BMB Reports 2017; 50(4): 164-174  https://doi.org/10.5483/BMBRep.2017.50.4.013
Nonsense-mediated mRNA decay at the crossroads of many cellular pathways
Fabrice Lejeune
BMB Reports 2017; 50(4): 175-185  https://doi.org/10.5483/BMBRep.2017.50.4.015
Translation initiation mediated by nuclear cap-binding protein complex
Incheol Ryu, and Yoon Ki Kim
BMB Reports 2017; 50(4): 186-193  https://doi.org/10.5483/BMBRep.2017.50.4.007
Translational control of mRNAs by 3′-Untranslated region binding proteins
Akio Yamashita, and Osamu Takeuchi
BMB Reports 2017; 50(4): 194-200  https://doi.org/10.5483/BMBRep.2017.50.4.040
Analyses of alternative polyadenylation: from old school biochemistry to high-throughput technologies
Hsin-Sung Yeh, Wei Zhang, and Jeongsik Yong
BMB Reports 2017; 50(4): 201-207  https://doi.org/10.5483/BMBRep.2017.50.4.019
Articles
miR-374 promotes myocardial hypertrophy by negatively regulating vascular endothelial growth factor receptor-1 signaling
Jong Sub Lee, Dong Woo Song, Jei Hyoung Park, Jin Ock Kim, Chunghee Cho, and Do Han Kim
BMB Reports 2017; 50(4): 208-213  https://doi.org/10.5483/BMBRep.2017.50.4.165
microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor
Heejin Lee, Hyosun Tak, So Jung Park, Yoon Kyung Jo, Dong Hyung Cho, and Eun Kyung Lee
BMB Reports 2017; 50(4): 214-219  https://doi.org/10.5483/BMBRep.2017.50.4.006
hnRNPK-regulated PTOV1-AS1 modulates heme oxygenase-1 expression via miR-1207-5p
Chang Hoon Shin, Seongho Ryu, and Hyeon Ho Kim
BMB Reports 2017; 50(4): 220-225  https://doi.org/10.5483/BMBRep.2017.50.4.024
Post-transcriptional and translational regulation of mRNA-like long non-coding RNAs by microRNAs in early developmental stages of zebrafish embryos
Kyung-Tae Lee, and Jin-Wu Nam
BMB Reports 2017; 50(4): 226-231  https://doi.org/10.5483/BMBRep.2017.50.4.025

e-submission

Current Issue

April 2017
Volume 50
Issue 4

2015 SCI Impact Factor 2.782

BIOCHEMISTRY & MOLECULAR BIOLOGY 138/289

Indexed/Covered by

Supported By