• Roles of mitochondria in neuronal development

    Fig. 1. Mitochondrial proteins, functions and dynamics. (A) Major function of mitochondria is energy production through OXPHOS. Glycolysis occurring in the cytosol produce pyruvate, which is necessary to fuel the tricarboxylic acid (TCA) cycle. The pentose phosphate pathway (PPP) is a shunt for glycolysis. Through the PPP, cells acquire required components for other cellular processes including nucleotide synthesis. In mitochondria, beta-oxidation occurs as the other mechanism of converting lipid to generate energy. (B) Most proteins localized in the mitochondria are produced from the nuclear genome (nDNA) and transported into mitochondria. Mitochondria contain its own genome (mitochondrial DNA, mtDNA) and produce 13 proteins comprising oxidative phosphorylation (OXPHOS) complex. (C) Dynamically changing morphology of mitochondria through continuous cycle of fusion and fission.
  • Potential roles of reactive oxygen species derived from chemical substances involved in cancer development in the female reproductive system

    Fig. 1. Relationship between ROS production and cancer cell development. Initiation, the first step among three stages in cancer, maintains the homeostasis of ROS against imbalance of ROS and regulates protein kinases, which have diverse cellular functions. Promotion, the second step, is related to DNA damage and induction of mutations appearing in the cellular signaling pathway. Progression, the third step, appears to activate EMTrelated genes and other intracellular signaling pathway markers. Therefore, the generation of ROS is crucial to the three developmental stages of cancer; initiation, promotion, and progression.
  • Downregulated microRNAs in the colorectal cancer: diagnostic and therapeutic perspectives

    Fig. 1. miRNAs: characteristics and biogenesis. The miRNAs are transcribed by the polymerase II into the primary transcripts (pri-miRNAs) that are cleaved by the Drosha. This processing drives the formation of the hairpin precursor (pre-miRNAs). Exportin 5 transports the pre-miRNAs to the cytoplasm, where the Dicer processes them into the miRNA duplexes. One strand of the duplex (mature miRNA) is incorporated into the RNA-induced silencing complex (RISC), and it binds to the 3’-UTR of the target mRNA, resulting in its degradation or translational repression.

BMB Reports 2018; 51(11): 545~607
Perspectives
Immune inflammatory modulation as a potential therapeutic strategy of stem cell therapy for ALS and neurodegenerative diseases
Seung Hyun Kim, Ki-Wook Oh, Hee Kyung Jin & Jae-Sung Bae
BMB Reports 2018; 51(11): 545-546  https://doi.org/10.5483/BMBRep.2018.51.11.255
In vivo action of RNA G-quadruplex in phloem development
Hyunwoo Cho, Hyun Seob Cho & Ildoo Hwang
BMB Reports 2018; 51(11): 547-548  https://doi.org/10.5483/BMBRep.2018.51.11.253
Invited Mini Review
Roles of mitochondria in neuronal development
Geurim Son & Jinju Han
BMB Reports 2018; 51(11): 549-556  https://doi.org/10.5483/BMBRep.2018.51.11.226
Contributed Mini Reviews
Potential roles of reactive oxygen species derived from chemical substances involved in cancer development in the female reproductive system
Soo-Min Kim, Kyung-A Hwang* & Kyung-Chul Choi *
BMB Reports 2018; 51(11): 557-562  https://doi.org/10.5483/BMBRep.2018.51.11.056
Downregulated microRNAs in the colorectal cancer: diagnostic and therapeutic perspectives
Rosa Hernández, Ester Sánchez-Jiménez, Consolación Melguizo, Jose Prados & Ana Rosa Rama
BMB Reports 2018; 51(11): 563-571  https://doi.org/10.5483/BMBRep.2018.51.11.116
Articles
An engineered PD-1-based and MMP-2/9-oriented fusion protein exerts potent antitumor effects against melanoma
Mulan Wei, Xujie Liu, Chunyu Cao, Jianlin Yang, Yafeng Lv, Jiaojiao Huang, Yanlin Wang & Ye Qin
BMB Reports 2018; 51(11): 572-577  https://doi.org/10.5483/BMBRep.2018.51.11.076
Telomere association of Oryza sativa Telomere Repeat-binding Factor Like 1 and its roles in telomere maintenance and development in rice, Oryza sativa L.
Mi Young Byun, Li Hua Cui, Hyoungseok Lee & Woo Taek Kim
BMB Reports 2018; 51(11): 578-583  https://doi.org/10.5483/BMBRep.2018.51.11.122
Genomic characterization of clonal evolution during oropharyngeal carcinogenesis driven by human papillomavirus 16
Jeesoo Chae, Weon Seo Park, Min Jung Kim, Se Song Jang, Dongwan Hong, Junsun Ryu, Chang Hwan Ryu, Ji-Hyun Kim, Moon-Kyung Choi, Kwan Ho Cho, Sung Ho Moon, Tak Yun, Jong-Il Kim & Yuh-Seog Jung
BMB Reports 2018; 51(11): 584-589  https://doi.org/10.5483/BMBRep.2018.51.11.091
3-(Naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride attenuates MPP+-induced cytotoxicity by regulating oxidative stress and mitochondrial dysfunction in SH-SY5Y cells
Seung-Ju Yang, Ji Woong Yang, Jung-Min Na, Ji Sun Ha, Soo Young Choi & Sung-Woo Cho
BMB Reports 2018; 51(11): 590-595  https://doi.org/10.5483/BMBRep.2018.51.11.123
STK899704 inhibits stemness of cancer stem cells and migration via the FAK-MEK-ERK pathway in HT29 cells
Hui-Ju Jang, Yesol Bak, Thu-Huyen Pham, Sae-Bom Kwon, Bo-Yeon Kim, JinTae Hong & Do-Young Yoon
BMB Reports 2018; 51(11): 596-601  https://doi.org/10.5483/BMBRep.2018.51.11.180
MicroRNA-301b promotes cell proliferation and apoptosis resistance in triple-negative breast cancer by targeting CYLD
Hongming Song, Dengfeng Li, Tianqi Wu, Dan Xie, Kaiyao Hua, Jiashu Hu, Xiaochong Deng, Changle Ji, Yijun Deng & Lin Fang*
BMB Reports 2018; 51(11): 602-607  https://doi.org/10.5483/BMBRep.2018.51.11.168

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November 2018
Volume 51
Issue 11

2017 SCI Impact Factor 3.085

BIOCHEMISTRY & MOLECULAR BIOLOGY 134/292

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