• Role of cyclic AMP in the eye with glaucoma

    Figure 1. Schematic diagram for proposed functional role of cAMP in glaucoma. The differential effects of cAMP generated by tmACs or sAC are shown in terms of IOP regulation and RGCs and ONH astrocytes protection. Black arrows with solid or dotted lines are experimentally confirmed or inferred from other types of astrocytes, respectively (see more detail in the text). Question marks represent what should be experimentally confirmed in future studies. Definitions: cAMP, cyclic adenosine 3′,5′-monophosphate; IOP, intraocular pressure; RGCs, retinal ganglion cells; ONH, optic nerve head; sAC, soluble adenylyl cyclase; tmACs, transmembrane adenylyl cyclases.
  • The role of extracellular biophysical cues in modulating the Hippo-YAP pathway

    Figure 1. Regulation of the Hippo-YAP
    pathway by extracellular biophysical cues. Mechanical stress inhibits Lats1/2
    kinase activity via Rho GTPase and the actin cytoskeleton. GPCR signaling can
    either activate or inhibit YAP/TAZ activity through the coupled Ga protein.
    Cellular junction and cell polarity modulate the Hippo pathway. Nutrient
    signaling modulates the core Hippo kinase and YAP activity through AMPK.
    YAP/TAZ activity is involved in amino-acid induced mTORC1 activation.


BMB Reports 2017; 50(2): 55~108
Perspectives
Dynamic lipopolysaccharide transfer cascade to TLR4/MD2 complex via LBP and CD14
Soo Jin Kim & Ho Min Kim*
BMB Reports 2017; 50(2): 55-57  
Identification of MFGE8 in mesenchymal stem cell secretome as an anti-fibrotic factor in liver fibrosis
Yu Jin Jang, Su Yeon An & Jong-Hoon Kim*
BMB Reports 2017; 50(2): 58-59  
Invited Mini Reviews
Role of cyclic AMP in the eye with glaucoma
Myoung Sup Shim, Keun-Young Kim & Won-Kyu Ju,*
BMB Reports 2017; 50(2): 60-70  
The role of extracellular biophysical cues in modulating the Hippo-YAP pathway
Jung-Soon Mo*
BMB Reports 2017; 50(2): 71-78  
Articles
Human adipose-derived mesenchymal stem cell spheroids improve recovery in a mouse model of elastase-induced emphysema
Ryeon Jin Cho,#, You-Sun Kim,#, Ji-Young Kim & Yeon-Mok Oh,*
BMB Reports 2017; 50(2): 79-84  
Zinc(II) ion promotes anti-inflammatory effects of rhSOD3 by increasing cellular association
Younghwa Kim,#, Yoon-Jae Jeon,#, Kang Ryu & Tae-Yoon Kim,*
BMB Reports 2017; 50(2): 85-90  
The hypertension drug, verapamil, activates Nrf2 by promoting p62-dependent autophagic Keap1 degradation and prevents acetaminophen-induced cytotoxicity
Da Hyun Lee,#, Jeong Su Park,#, Yu Seol Lee, Su Haeng Sung, Yong-ho Lee & Soo Han Bae,*
BMB Reports 2017; 50(2): 91-96  

Extracellular S100A4 negatively regulates osteoblast function by activating the NF-κB pathway

Haemin Kim, Yong Deok Lee, Min Kyung Kim, Jun-Oh Kwon, Min-Kyoung Song, Zang Hee Lee & Hong-Hee Kim*
BMB Reports 2017; 50(2): 97-102  
Heme oxygenase-1 (HO-1)/carbon monoxide (CO) axis suppresses RANKL-induced osteoclastic differentiation by inhibiting redox-sensitive NF-κB activation
Sun-Uk Bak, Suji Kim, Hae-Jun Hwang, Jung-A Yun, Wan-Sung Kim, Moo-Ho Won, Ji-Yoon Kim, Kwon-Soo Ha, Young-Guen Kwon & Young-Myeong Kim,*
BMB Reports 2017; 50(2): 103-108  

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February 2017
Volume 50
Issue 2

2015 SCI Impact Factor 2.782

BIOCHEMISTRY & MOLECULAR BIOLOGY 138/289

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