• Histone tail cleavage as a novel epigenetic regulatory mechanism for gene expression

    Schematic model showing the functional roles of histone cleavage in gene expression. (A) Influence of genomic DNA or chromatin compaction on accessibility. Histone tail cleavages by protease might generate open chromatin structures and increase DNA accessibility for transcription factors, thereby contributing to gene activation. (B) Induction of histone eviction. The truncated histone by protease is unstable in the nucleosome. Histone tail cleavage may induce histone eviction, allowing easy access of transcription factors to DNA elements during gene activation. (C) Removal of PTMs and interacting proteins. Histone tail cleavage may lead to the radical removal of multiple modifications, resulting in blockage of the recruitment of effector proteins (“Reader” protein) or other PTM cascades on histone tails.
  • The role of necroptosis in the treatment of diseases

    Necroptosis regulators and signaling pathways in necroptosis activation. Upon TNF receptor ligation, a signal transduction mediated via RIP1, caspase activation, and tBID cleavage occurs, resulting in apoptotic cell death. Active caspase-8 inhibits necroptosis via cleavage of RIP1 and RIP3. Inhibition of caspase leads to the formation of a physical complex of RIP1 with RIP3 to trigger downstream signaling events including MLKL and PGAM5 recruitment, and transduction of cytosolic death signals to mitochondria, resulting in necroptosis.
  • Role of estrogen and RAS signaling in repeated implantation failure

    Estrogen production. Estradiol is synthesized in the ovary based on the two-cell theory. In theca cells, androstenedione or testosterone is generated from cholesterol. In granulosa cells, estrone or estradiol is produced from androstenedione or testosterone by aromatase, which is a cell-specific enzyme. Estradiol in the blood is converted into estriol in the liver or placenta (modified from Hiller (1, 3)).

BMB Reports 2018; 51(5): 207~260
Perspectives
Chitinase 3-like-1, a novel regulator of Th1/CTL responses, as a therapeutic target for increasing anti-tumor immunity
Do-Hyun Kim, and Je-Min Choi
BMB Reports 2018; 51(5): 207-208  https://doi.org/10.5483/BMBRep.2018.51.5.094
Insulin receptor substrate 2: a bridge between Hippo and AKT pathways
Sun-Hye Jeong, and Dae-Sik Lim
BMB Reports 2018; 51(5): 209-210  https://doi.org/10.5483/BMBRep.2018.51.5.095
Invited Mini Reviews
Histone tail cleavage as a novel epigenetic regulatory mechanism for gene expression
Sun-Ju Yi, and Kyunghwan Kim
BMB Reports 2018; 51(5): 211-218  https://doi.org/10.5483/BMBRep.2018.51.5.053
The role of necroptosis in the treatment of diseases
Young Sik Cho
BMB Reports 2018; 51(5): 219-224  https://doi.org/10.5483/BMBRep.2018.51.5.074
Role of estrogen and RAS signaling in repeated implantation failure
Kwonho Hong, and Youngsok Choi
BMB Reports 2018; 51(5): 225-229  https://doi.org/10.5483/BMBRep.2018.51.5.045
Articles
Selective regulation of osteoclast adhesion and spreading by PLCγ/PKCα-PKCδ/RhoA-Rac1 signaling
Jin-Man Kim, Kyunghee Lee, and Daewon Jeong
BMB Reports 2018; 51(5): 230-235  https://doi.org/10.5483/BMBRep.2018.51.5.198
Functional roles of glutamic acid E143 and E705 residues in the N-terminus and transmembrane domain 7 of Anoctamin 1 in calcium and noxious heat sensing
Jonghyun Choi, Yongwoo Jang, Haedong Kim, Jungwon Wee, Sinyoung Cho, Woo Sung Son, Sung Min Kim, and Young Duk Yang
BMB Reports 2018; 51(5): 236-241  https://doi.org/10.5483/BMBRep.2018.51.5.199
Imprinted gene Zinc finger protein 127 is a novel regulator of master pluripotency transcription factor, Oct4
Yoo-Wook Kwon, Hyo-Suk Ahn, Joo-Young Park, Han-Mo Yang, Hyun-Jai Cho, and Hyo-Soo Kim
BMB Reports 2018; 51(5): 242-248  https://doi.org/10.5483/BMBRep.2018.51.5.196
Medicarpin induces lipolysis via activation of Protein Kinase A in brown adipocytes
Khan Mohammad Imran, Dahyeon Yoon, Tae-Jin Lee, and Yong-Sik Kim
BMB Reports 2018; 51(5): 249-254  https://doi.org/10.5483/BMBRep.2018.51.5.228
Inhibition of Wntless/GPR177 suppresses gastric tumorigenesis
Jaesung Seo, Hyun Jung Kee, Hye Ji Choi, Jae Eun Lee, Soo-Yeon Park, Seung-Hyun Lee, Mi-Hyeon Jeong, Garam Guk, SooYeon Lee, Kyung-Chul Choi, Yoon Young Choi, Hyunki Kim, Sung Hoon Noh, Ho-Geun Yoon, and Jae-Ho Cheong
BMB Reports 2018; 51(5): 255-260  https://doi.org/10.5483/BMBRep.2018.51.5.046

e-submission

Current Issue

May 2018
Volume 51
Issue 5

2016 SCI Impact Factor 3.089

BIOCHEMISTRY & MOLECULAR BIOLOGY 138/289

Indexed/Covered by