• Mitochondria: multifaceted regulators of aging

    Fig. 1. Mitochondrial Communication Modes. (A) Mitochondria communicate to the nucleus and other cells (i.e., mitochondrial endocrine signaling) using various mediators such as ROS, UPRmt, DAMPs, and mitochondrialencoded MDPs. (B) Mitochondria also
    communicate with other organelles (e.g., endoplasmic reticulum, lysosomes, and peroxisomes) to coordinate complex cellular processes.
  • Cellular senescence: a promising strategy for cancer therapy

    Fig. 1. Molecular pathways of cellular senescence. DDR (DNA damage response) triggered by telomere erosion or OIS (oncogeneinduced senescence) is mediated by ATM/CHK2 and ATR/CHK1, which blocks cell cycle progression via phosphorylation and stabilization of p53. Activated p53 induces transcription of CDK inhibitor p21CIP1encoded by CDKN1A, which inhibits CDK2 activity, thereby activating RB and inducing cell cycle arrest. In parallel, various stressors also induce expression of the CDKN2A locus, which consists of p14ARF, p16INK4a, and p15INK4B. p14ARF prevents p53 destabilization by degrading the MDM2 protooncogene. Meanwhile, p16INK4a and p15INK4B suppress CDK4 and CDK6, thereby eventually activating RB. PICS (PTEN loss-induced cellular senescence) also activates p53 through the mTOR pathway. Altogether, prolonged activation of the p53/p21CIP1 and p16INK4a/RB signaling pathways leads to hypophosphorylation of RB, which blocks the cell cycle in G1 phase, and ultimately causes cellular senescence. RS and SIPS indicate replicative senescence and stress-induced premature senescence, respectively.
  • Cellular senescence in cancer

    Fig. 1. Schematic representation of the role of senescent cells in tumors. Senescent cells express SASP and are involved in interactions with the tissue microenvironment, including extracellular matrix (ECM) degradation, immune cells infiltration, and
    cancer invasion.
  • Senotherapeutics: emerging strategy for healthy aging and age-related disease

    Fig. 1. Senotherapeutics targeting SCs. CS induced by diverse factors is involved in many biological processes, embryonic development, tissue homeostasis, and tissue dysfunction, thus contributing to age-related pathologies and lifespan. Therefore, senotherapeutics targeting SCs is an emerging strategy of aging intervention for extension of health span and prevention and treatment of ARDs. Senotherapeutics is comprised of 3 classes: senolytics which kill SCs selectively; senomorphics which modulates or even reverses the phenotypes of SCs to those of young cells by interfering with triggers of CS, targeting SCs directly, or blocking SASP: and mediators of the immune-system clearance of SCs.

BMB Reports 2019; 52(1): 1~108
Editorial
Cellular senescence, aging, and age-related disease: Special issue of BMB Reports in 2019
Jae-Seon Lee
BMB Reports 2019; 52(1): 1-2  
Perspective
Juxtacrine regulation of cellular senescence
Masashi Narita*
BMB Reports 2019; 52(1): 3-4  
Invited Mini Reviews
Metabolic features and regulation in cell senescence
So Mee Kwon, Sun Mi Hong, Young-Kyoung Lee, Seongki Min & Gyesoon Yoon
BMB Reports 2019; 52(1): 5-12  
Mitochondria: multifaceted regulators of aging
Jyung Mean Son & Changhan Lee
BMB Reports 2019; 52(1): 13-23  
Sirtuin signaling in cellular senescence and aging

Shin-Hae Lee, Ji-Hyeon Lee, Hye-Yeon Lee & Kyung-Jin Min*

BMB Reports 2019; 52(1): 24-34  
Cellular senescence: a promising strategy for cancer therapy
Seongju Lee & Jae-Seon Lee
BMB Reports 2019; 52(1): 35-41  
Cellular senescence in cancer
Young Hwa Kim & Tae Jun Park*
BMB Reports 2019; 52(1): 42-46  
Senotherapeutics: emerging strategy for healthy aging and age-related disease
Eok-Cheon Kim & Jae-Ryong Kim*
BMB Reports 2019; 52(1): 47-55  
Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis
EunJin Bang, Bonggi Lee, Sang-Gyun Noh, Dae Hyun Kim, Hee Jin Jung, Sugyeong Ha, Byung Pal Yu & Hae Young Chung
BMB Reports 2019; 52(1): 56-63  
Sarcopenia targeting with autophagy mechanism by exercise
Sung Sup Park Young-Kyo Seo & Ki-Sun Kwon
BMB Reports 2019; 52(1): 64-69  
Growth signaling and longevity in mouse models
Seung-Soo Kim & Cheol-Koo Lee
BMB Reports 2019; 52(1): 70-85  
Multi-level remodeling of transcriptional landscapes in aging and longevity
Rochelle W. Lai, Ryan Lu, Prakroothi S. Danthi, Juan I. Bravo, Alexandre Goumba, Nirmal Kumar Sampathkumar & Bérénice A. Benayoun
BMB Reports 2019; 52(1): 86-108  

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January 2019
Volume 52
Issue 1

2017 SCI Impact Factor 3.085

BIOCHEMISTRY & MOLECULAR BIOLOGY 134/292

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