Fig. 1. Tau protein isoforms in the human brain. Six tau isoforms are present in the human brain through different combinations of the splicing of exons 2, 3, and/or 10. The aspects of the N-terminal projection domain, N1 (green) and N2 (blue), are produced from exons 2 and 3, respectively. Exon 10 encodes the second aspect of the microtubule-binding repeat domain, R2 (red). Depending on the presence of the R2 domain, tau proteins become either 3R or 4R tau.
Fig. 1. MG53 function in cell membrane repair and insulin signaling. (A) MG53 contains 477 amino acids with RING (Really Interesting New Gene), B-box, and Coil-coil domain at the amino terminus, plus a SPRY domain at the carboxyl terminus. (B) MG53 participates in the nucleation of transport vesicles to sites of membrane injury. It binds to phosphatidylserine (PS) and undergoes oligomerization when the cell changes from reduced to oxidized environment at the injury site. Entry of extracellular Ca2＋ enables fusion of vesicles for formation of a repair patch. (C) MG53 contains an E3 Ligase activity that facilitates the ubiquitination of IRS-1. The proteasome-mediated degradation of IRS-1 contributes to the regulation of insulin signaling in muscle cells.
Online First articles have been peer reviewed, accepted for publication and published online; they have not yet been assigned to a journal issue. When these articles are published in an issue, they will be removed from this page.
Online First articles are copy-edited, typeset and approved by the authors before publication.
Korean Society for Biochemistry and Molecular Biology. All Rights Reserved. The Korean Federation of Science and Technology Societies 801, 22, Teheran-ro 7Gil, Gangnam-gu, Seoul 06130, South Korea Tel) 82-2-508-7434 Fax) 82-2-508-7578 e-mail) email@example.com Powered by INFOrang.co., Ltd