• The history and regulatory mechanism of the Hippo pathway

    Schematic model of the Hippo pathway and cross-talk with other signaling pathways in mammals. The Hippo pathway is a kinase cascade that consists of MST1/2-LATS1/2 and can be activated by diverse stimuli including cell density, polarity and mechanical cues to suppress YAP/TAZ transcriptional activity. Many modulators in the Hippo pathway have been added via multiple approaches (left panel). The crosstalk of the Hippo pathway with other signaling pathways such as Wnt/β-catenin, Notch and TGF-β to regulate YAP/TAZ activity (right panel).

BMB Reports 2018; 51(3): 105~162
Editorial
Hippo signaling: Special issue of BMB Reports in 2018
Eek-hoon Jho
BMB Reports 2018; 51(3): 105-105  https://doi.org/10.5483/BMBRep.2018.51.3.044
Invited Mini Reviews
The history and regulatory mechanism of the Hippo pathway
Wantae Kim, and Eek-hoon Jho
BMB Reports 2018; 51(3): 106-118  https://doi.org/10.5483/BMBRep.2018.51.3.022
Clinical implications of the Hippo-YAP pathway in multiple cancer contexts
Han-Byul Kim, and Seung-Jae Myung
BMB Reports 2018; 51(3): 119-125  https://doi.org/10.5483/BMBRep.2018.51.3.018
DNA binding partners of YAP/TAZ
Min-Kyu Kim, Ju-Won Jang, and Suk-Chul Bae
BMB Reports 2018; 51(3): 126-133  https://doi.org/10.5483/BMBRep.2018.51.3.015
Upstream paths for Hippo signaling in Drosophila organ development
Kwang-Wook Choi
BMB Reports 2018; 51(3): 134-142  https://doi.org/10.5483/BMBRep.2018.51.3.027
Regulation of the Hippo signaling pathway by ubiquitin modification
Youngeun Kim, and Eek-hoon Jho
BMB Reports 2018; 51(3): 143-150  https://doi.org/10.5483/BMBRep.2018.51.3.017
Regulation of Hippo signaling by actin remodeling
Jimyung Seo, and Joon Kim
BMB Reports 2018; 51(3): 151-156  https://doi.org/10.5483/BMBRep.2018.51.3.012
Hippo-YAP/TAZ signaling in angiogenesis
Jeong Ae Park, and Young-Guen Kwon
BMB Reports 2018; 51(3): 157-162  https://doi.org/10.5483/BMBRep.2018.51.3.016

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Current Issue

March 2018
Volume 51
Issue 3

2016 SCI Impact Factor 3.089

BIOCHEMISTRY & MOLECULAR BIOLOGY 138/289

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