• Role of cyclic AMP in the eye with glaucoma

    Schematic diagram for proposed functional role of cAMP in glaucoma. The differential effects of cAMP gene-rated by tmACs or sAC are shown in terms of IOP regulation and RGCs and ONH astrocytes protection. Black arrows with solid or dotted lines are experimentally confirmed or inferred from other types of astrocytes, respectively (see more detail in the text). Question marks represent what should be experimentally confirmed in future studies. Definitions: cAMP, cyclic adenosine 3′,5′-monophosphate; IOP, intraocular pressure; RGCs, retinal ganglion cells; ONH, optic nerve head; sAC, soluble adenylyl cyclase; tmACs, transmembrane adenylyl cyclases.
  • The role of extracellular biophysical cues in modulating the Hippo-YAP pathway

    Regulation of the Hippo-YAP pathway by extracellular biophysical cues. Mechanical stress inhibits Lats1/2 kinase activity via Rho GTPase and the actin cytoskeleton. GPCR signaling can either activate or inhibit YAP/TAZ activity through the coupled Gα protein. Cellular junction and cell polarity modulate the Hippo pathway. Nutrient signaling modulates the core Hippo kinase and YAP activity through AMPK. YAP/TAZ activity is involved in amino-acid induced mTORC1 activation.

BMB Reports 2017; 50(2): 55~108
Perspectives
Dynamic lipopolysaccharide transfer cascade to TLR4/MD2 complex via LBP and CD14
Soo Jin Kim, and Ho Min Kim
BMB Reports 2017; 50(2): 55-57  https://doi.org/10.5483/BMBRep.2017.50.2.011
Identification of MFGE8 in mesenchymal stem cell secretome as an anti-fibrotic factor in liver fibrosis
Yu Jin Jang, Su Yeon An, and Jong-Hoon Kim
BMB Reports 2017; 50(2): 58-59  https://doi.org/10.5483/BMBRep.2017.50.2.012
Invited Mini Reviews
Role of cyclic AMP in the eye with glaucoma
Myoung Sup Shim, Keun-Young Kim, and Won-Kyu Ju
BMB Reports 2017; 50(2): 60-70  https://doi.org/10.5483/BMBRep.2017.50.2.200
The role of extracellular biophysical cues in modulating the Hippo-YAP pathway
Jung-Soon Mo
BMB Reports 2017; 50(2): 71-78  https://doi.org/10.5483/BMBRep.2017.50.2.199
Articless
Human adipose-derived mesenchymal stem cell spheroids improve recovery in a mouse model of elastase-induced emphysema
Ryeon Jin Cho, You-Sun Kim, Ji-Young Kim, and Yeon-Mok Oh
BMB Reports 2017; 50(2): 79-84  https://doi.org/10.5483/BMBRep.2017.50.2.101
Zinc(II) ion promotes anti-inflammatory effects of rhSOD3 by increasing cellular association
Younghwa Kim, Yoon-Jae Jeon, Kang Ryu, and Tae-Yoon Kim
BMB Reports 2017; 50(2): 85-90  https://doi.org/10.5483/BMBRep.2017.50.2.150
The hypertension drug, verapamil, activates Nrf2 by promoting p62-dependent autophagic Keap1 degradation and prevents acetaminophen-induced cytotoxicity
Da Hyun Lee, Jeong Su Park, Yu Seol Lee, Su Haeng Sung, Yong-ho Lee, and Soo Han Bae
BMB Reports 2017; 50(2): 91-96  https://doi.org/10.5483/BMBRep.2017.50.2.188
Extracellular S100A4 negatively regulates osteoblast function by activating the NF-κB pathway
Haemin Kim, Yong Deok Lee, Min Kyung Kim, Jun-Oh Kwon, Min-Kyoung Song, Zang Hee Lee, and Hong-Hee Kim
BMB Reports 2017; 50(2): 97-102  https://doi.org/10.5483/BMBRep.2017.50.2.170
Heme oxygenase-1 (HO-1)/carbon monoxide (CO) axis suppresses RANKL-induced osteoclastic differentiation by inhibiting redox-sensitive NF-κB activation
Sun-Uk Bak, Suji Kim, Hae-Jun Hwang, Jung-A Yun, Wan-Sung Kim, Moo-Ho Won, Ji-Yoon Kim, Kwon-Soo Ha, Young-Guen Kwon, and Young-Myeong Kim
BMB Reports 2017; 50(2): 103-108  https://doi.org/10.5483/BMBRep.2017.50.2.220

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February 2017
Volume 50
Issue 2

2015 SCI Impact Factor 2.782

BIOCHEMISTRY & MOLECULAR BIOLOGY 138/289

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