• Therapeutic implication of autophagy in neurodegenerative diseases

    Fig. 1. Regulation of autophagy signaling pathway. Autophagy may initiate deprivation of nutrients or growth factors which activate AMPK and/or inhibition of mTORC1, leading to stimulation of ULK complex (FIP200 and ATG13). Beclin-1 become phosphorylated, leading to VPS34 activation and then initiation of phagophore formation. VPS34 complex function comprises a regulatory subunit like VPS15 (p150) and Beclin-1, their connection being with other regulatory factors e.g. AMBRA, ATG14, UVRAG, and BIF-1. Atg5–Atg12 conjugation involves Atg7 and Atg10 to form a complex, Atg12-atg5-Atg16 influences the formation of phagophores. Atg5 and Atg12 forms a complex with Atg16, which acts like an E3-function towards LC3-PE assembly (LC3-II). This has a role in the initiation of phagophore formation. LC3-II is a particular autophagy indicator marker which is eventually disrupted by autolysosomes. Autophagosome maturation also involves fusion with lysosomes which are mediated by Rab7, ESCRT and SNARE proteins, eventually leading to cargo degradation and recycling of nutrients and metabolites.
  • Structure, signaling and the drug discovery of the Ras oncogene protein

    Fig. 2. Regulating signaling downstream of Ras. In the active GTP-bound state, Ras interacts with several families of effector proteins,
    resulting in stimulation of their catalytic activities. Raf protein kinases activate mitogen-activated protein kinase kinases 1 and 2 (MEK1 and MEK2), which leads to ERK1/2 activation. Phosphoinositide 3-kinases (PI3Ks) generate second-messenger lipids and activate numerous target proteins, including the survival signaling kinase AkT/PDK1. Ras binding activates Ral specific guanine-nucleotide-exchange factors (Ral-GEFs) by targeting them to their substrates, Ral GTPases, which are present in the plasma membrane. Phospholipase Cε (PLCε) catalyses the activation of protein kinase C (PKC) and mobilization of calcium from intracellular stores.

BMB Reports 2017; 50(7): 343~389
An FCA-mediated epigenetic route towards thermal adaptation of autotrophic development in plants
Hyo-Jun Lee, Jun-Ho Ha & Chung-Mo Park
BMB Reports 2017; 50(7): 343-344  
Invited Mini Review
Therapeutic implication of autophagy in neurodegenerative diseases
Md. Ataur Rahman & Hyewhon Rhim
BMB Reports 2017; 50(7): 345-354  
Contributed Mini Review
Structure, signaling and the drug discovery of the Ras oncogene protein
Chang Woo Han, Mi Suk Jeong & Se Bok Jang*
BMB Reports 2017; 50(7): 355-360  
Survivin protects fused cancer cells from cell death
Mihyang Do, In-Hae Kwak, Ju-Hyun Ahn, In Jeong Lee & Jae-Ho Lee
BMB Reports 2017; 50(7): 361-366  
Monoacylglycerol O-acyltransferase 1 (MGAT1) localizes to the ER and lipid droplets promoting triacylglycerol synthesis
Yoo Jeong Lee & Jae-woo Kim
BMB Reports 2017; 50(7): 367-372  
Phosphorylation of p53 at threonine 155 is required for Jab1-mediated nuclear export of p53
Eun-Woo Lee, Wonkyung Oh, Hosung Paul Song & Won Kon Kim
BMB Reports 2017; 50(7): 373-378  
Repression of the F-box protein Skp2 is essential for actin damage-induced tetraploid G1 arrest

Yongsam Jo & Deug Y. Shin*

BMB Reports 2017; 50(7): 379-383  
Endothelial miR-26a regulates VEGF-Nogo-B receptor-mediated angiogenesis
Ha-neul Jo, Hyesoo Kang, Aram Lee, Jihea Choi, Woochul Chang, Myeong-Sok Lee & Jongmin Kim
BMB Reports 2017; 50(7): 384-389  


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July 2017
Volume 50
Issue 7

2016 SCI Impact Factor 3.089


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