• Sex as an important biological variable in biomedical research

    Schematic drawing shows male-biased preclinical and clinical research can leave detrimental side effects for women undetected till marketing.
  • Emerging role of RUNX3 in the regulation of tumor microenvironment

    Role of RUNX3 in the tumor microenvironment and its impact on EMT, tumor growth, invasion and metastasis. A growing tumor lacks oxygen (O2) and becomes hypoxic. The hypoxic tumor modulates the tumor microenvironment for its further progression to malignancy. Extracellular matrix (ECM)-secreted cytokines facilitate epithelial-mesenchymal transition (EMT) and invasion, increased tumor-infiltrating immune cells suppress immunosurveillance and increase angiogenesis, tumor-modified cancer associated fibroblast (CAF) produce chemokines that attract other tumor-growth-favoring cells into tumor. RUNX3 can repress these phenomena by targeting tumor infiltrating cells, ECM and their secretions.

BMB Reports 2018; 51(4): 163~205
Perspectives
Photoperiod sensing system for timing of flowering in plants
Byoung-Doo Lee, Joon-Yung Cha, Mi Ri Kim, Nam-Chon Paek, and Woe-Yeon Kim
BMB Reports 2018; 51(4): 163-164  https://doi.org/10.5483/BMBRep.2018.51.4.052
Estrogen-related receptor γ is a novel catabolic regulator of osteoarthritis pathogenesis
Young-Ok Son, and Jang-Soo Chun
BMB Reports 2018; 51(4): 165-166  https://doi.org/10.5483/BMBRep.2018.51.4.019
Invited Mini Reviews
Sex as an important biological variable in biomedical research
Suk Kyeong Lee
BMB Reports 2018; 51(4): 167-173  https://doi.org/10.5483/BMBRep.2018.51.4.034
Emerging role of RUNX3 in the regulation of tumor microenvironment
Sarala Manandhar, and You Mie Lee
BMB Reports 2018; 51(4): 174-181  https://doi.org/10.5483/BMBRep.2018.51.4.033
Articles
Force-mediated proinvasive matrix remodeling driven by tumor-associated mesenchymal stem-like cells in glioblastoma
Eun-Jung Lim, Yongjoon Suh, Seungmo Kim, Seok-Gu Kang, and Su-Jae Lee
BMB Reports 2018; 51(4): 182-187  https://doi.org/10.5483/BMBRep.2018.51.4.185
Cell proliferation and migration mechanism of caffeoylserotonin and serotonin via serotonin 2B receptor in human keratinocyte HaCaT cells
Hye-Eun Kim, Hyejoung Cho, Atsushi Ishihara, Byungkuk Kim, and Okjoon Kim
BMB Reports 2018; 51(4): 188-193  https://doi.org/10.5483/BMBRep.2018.51.4.209
Human amnion-derived mesenchymal stem cells induced osteogenesis and angiogenesis in human adipose-derived stem cells via ERK1/2 MAPK signaling pathway
Yuli Wang, Xichen Chen, Ying Yin, and Song Li
BMB Reports 2018; 51(4): 194-199  https://doi.org/10.5483/BMBRep.2018.51.4.005
Early potential effects of resveratrol supplementation on skeletal muscle adaptation involved in exercise-induced weight loss in obese mice
Jingyu Sun, Chen Zhang, MinJeong Kim, Yajuan Su, Lili Qin, Jingmei Dong, Yunhe Zhou, and Shuzhe Ding
BMB Reports 2018; 51(4): 200-205  https://doi.org/10.5483/BMBRep.2018.51.4.236

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Current Issue

April 2018
Volume 51
Issue 4

2016 SCI Impact Factor 3.089

BIOCHEMISTRY & MOLECULAR BIOLOGY 138/289

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