• The Yin and Yang of RNA surveillance in B lymphocytes and antibody-secreting plasma cells

    Abundance of nonproductive V(D)J rearrangements in B-lineage cells. (A) Schematic representation of productive and nonproductive V(D)J rearrangements during the generation of primary antibody repertoire. V(D)J recombination is initiated by a monoallelic V to DJ recombination at the IgH locus (biallelic D–J rearrangements are not depicted). If successful, then V to J recombination occurs at Ig light chain (IgL) loci. Successive IgL rearrangements are possible due to the fact that there are two Igκ and two Igλ alleles (not depicted). Pre-B cell receptor (pre-BCR) or BCR-mediated feedback signalling upon in-frame rearrangement of one IgH or IgL allele (i.e., VDJ+ or VJ+) prevents V(D)J recombination on the second allele (32). By contrast, a nonproductive V(D)J recombination on one Ig allele (i.e. VDJ− or VJ−) induces rearrangement on the second allele. The imprecise nature of V(D)J junctions generates ~1/3 of productive and ~2/3 of nonproductive V(D)J-rearranged alleles. Hence, most B-lineage cells harbour nonproductively-recombined Ig alleles in their genome (red parts in pie charts). If the two attempts on both Ig alleles are unsuccessful, the cell is programmed to die by apoptosis (dashed circles). (B) PTCs introduced during the error-prone V(D)J recombination process (red stars) or by somatic hypermutations (SHM; yellow stars) can activate different modes of NMD degradation. Frameshift V(D)J junctions can lead to the appearance of PTCs in the variable (V) exon or in the downstream adjacent constant exon. SHM can lead to the appearance of PTCs in the first leader exon (L1: L-part1) or in the V exon, with a greater abundance in the complement-determining regions (CDRs). For IgH mRNAs, PTC introduced by SHM or during V(D)J recombination can elicit exon junction complex (EJC)-dependent NMD. EJCs that remain bound to mRNAs after a pioneer round of translation are depicted (blue ovals). As good NMD candidates, PTC-containing IgH mRNAs are strongly degraded by NMD (up to 100-fold) (1, 9, 59). However, it has been demonstrated that some nonsense codons in the 5′-half of the VDJ exon could not elicit strong NMD degradation (73). Similarly, PTCs close to the initiation codon are NMD resistant in other models likely due to a critical interaction between PABPC1 with the translation initiation complex (74, 75). For nonproductive Igκ alleles, PTCs are located at the end of the V exon or within the last constant Cκ exon. Hence, these PTC-containing IgL mRNAs could not elicit EJC-dependent NMD degradation, although they are likely to be targeted by a PTC-PABC1 distance-dependent mode of NMD which induces a less efficient degradation (~2-fold) (5).
  • The role of cell type-specific mitochondrial dysfunction in the pathogenesis of Alzheimer’s disease

    Mitochondrial alterations in AD. The effect of AD pathology on mitochondrial function for energy production, transport and dynamics.

BMB Reports 2019; 52(12): 671~728
Invited Mini Reviews
The Yin and Yang of RNA surveillance in B lymphocytes and antibody-secreting plasma cells
Jean-Marie Lambert, Nivine Srour† & Laurent Delpy*
BMB Reports 2019; 52(12): 671-678  https://doi.org/10.5483/BMBRep.2019.52.12.232
The role of cell type-specific mitochondrial dysfunction in the pathogenesis of Alzheimer’s disease
Dong Kyu Kim & Inhee Mook-Jung*
BMB Reports 2019; 52(12): 679-688  https://doi.org/10.5483/BMBRep.2019.52.12.282
Articles
Mitochondrial genome mutations in mesenchymal stem cells derived from human dental induced pluripotent stem cells
Jumi Park, Yeonmi Lee, Joosung Shin, Hyeon-Jeong Lee, Young-Bum Son, Bong-Wook Park, Deokhoon Kim, Gyu-Jin Rho & Eunju Kang
BMB Reports 2019; 52(12): 689-694  https://doi.org/10.5483/BMBRep.2019.52.12.045
Transduced Tat-CIAPIN1 reduces the inflammatory response on LPS- and TPA-induced damages
Hyeon Ji Yeo Min Jea Shin, Ji Ho You, Jeong Su Kim, Min Young Kim, Dae Won Kim, Duk-Soo Kim, Won Sik Eum & Soo Young Choi
BMB Reports 2019; 52(12): 695-699  https://doi.org/10.5483/BMBRep.2019.52.12.245
LIR motifs and the membrane-targeting domain are complementary in the function of RavZ
Sang-Won Park, Yong-Woo Jun, Pureum Jeon, You-Kyung Lee, Ju-Hui Park, Seung-Hwan Lee, Jin-A Lee & Deok-Jin Jang
BMB Reports 2019; 52(12): 700-705  https://doi.org/10.5483/BMBRep.2019.52.12.211
Inhibition of p90RSK activation sensitizes triple-negative breast cancer cells to cisplatin by inhibiting proliferation, migration and EMT
Yujin Jin, Diem Thi Ngoc Huynh, Keon Wook Kang, Chang-Seon Myung & Kyung-Sun Heo
BMB Reports 2019; 52(12): 706-711  https://doi.org/10.5483/BMBRep.2019.52.12.234
TOMM20 as a potential therapeutic target of colorectal cancer
Sang-Hee Park, Ah-Reum Lee, Keonwoo Choi, Soyoung Joung, Jong-Bok Yoon & Sungjoo Kim
BMB Reports 2019; 52(12): 712-717  https://doi.org/10.5483/BMBRep.2019.52.12.249
Errata
Erratum to: Severe combined immunodeficiency pig as an emerging animal model for human diseases and regenerative medicines
Muhammad Arsalan Iqbal, Kwonho Hong, Jin Hoi Kim & Youngsok Choi
BMB Reports 2019; 52(12): 718-727  
Erratum to: Regulation of post-translational modification in breast cancer treatment
Kyung-Sun Heo
BMB Reports 2019; 52(12): 728-728  

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December 2019
Volume 52
Issue 12

2018 SCI Impact Factor 2.966

BIOCHEMISTRY & MOLECULAR BIOLOGY 134/292

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