• Regulation of post-translational modification in breast cancer treatment

    Fig. 1. The scheme of SUMOylation and deSUMOylation pathway. (A) Protein SUMOylation is associated with a recycling system
    consisting of conjugation and deconjugation pathways. Both conjugation and deconjugation enzymes mediate the dynamic and reversible process of SUMOylation. The protein SUMOylation alters protein activation, transcriptional activity, stability, and localization change. (B) SUMO proteins covalently modify certain residues of specific target substrates and change the function of these substrates. The conjugation pathway is mediated by SUMO E1, E2, E3 enzymes, whereas the deconjugation pathway is mediated by SUMOisopeptidase, SENPs.
  • E3 ubiquitin ligases and deubiquitinases as modulators of TRAIL-mediated extrinsic apoptotic signaling pathway

    Fig. 1. The process of the ubiquitin proteasome system (UPS). 1) Ubiquitin (Ub) is activated by E1 activating enzymes in an ATP-dependent manner, then transferred to E2 conjugating enzymes. E2 conjugating enzymes can recruit E3 ligases enzymes with target substrates. E3 ligase enzymes directly catalyze transfer of activated ubiquitin from E2 conjugating enzymes to substrates, leading to the formation of polyubiquitin chains on target substrates. This process is called ubiquitination. Lys48- and Lys11-linked polyubiquitin chains usually induce degradation of target substrate through proteasome activation. Conversely, Lys63-linked polyubiquitin chains regulate cellular signaling and trafficking. 2) Ubiquitination of target substrate is reversed by deubiquitinases (DUBs). DUBs are critical roles for regulating the function of ubiquitinated proteins by removal of polyubiquitin chains. This process is called deubiquitination. In addition, ubiquitin released from substrates by DUBs can be recycled for activation of ubiquitination.
  • Epigenetic memory in gene regulation and immune response

    Fig. 3. Transcriptional memory in immune cells. (A) Monocyte exposed to immune stimulation such as lipopolysaccharide (LPS) or beta-glucan exhibits different levels of H3K4me1, H3K4me3 and H3K27ac globally even after differentiation into macrophage. (B) Effector T cell exhibits transcriptional memory upon 2nd stimulation. At that time, the chromosomal allelic pairing and Pol II pausing are occurred at locus of the related genes, which lead to bi-allelic RNA expression and finally rapid gene expression.

BMB Reports 2019; 52(2): 109~162
Perspectives
The coordinated regulation of mitochondrial structure and function by Drp1 for mitochondrial quality surveillance
Hyo Min Cho and Woong Sun
BMB Reports 2019; 52(2): 109-110  https://doi.org/10.5483/BMBRep.2019.52.2.032
Acid sphingomyelinase-mediated blood-brain barrier disruption in aging
Min Hee Park, Hee Kyung Jin and Jae-sung Bae
BMB Reports 2019; 52(2): 111-112  https://doi.org/10.5483/BMBRep.2019.52.2.033
Invited Mini Reviews
Regulation of post-translational modification in breast cancer treatment
Kyung-Sun Heo
BMB Reports 2019; 52(2): 113-118  https://doi.org/10.5483/BMBRep.2019.52.2.017
E3 ubiquitin ligases and deubiquitinases as modulators of TRAIL-mediated extrinsic apoptotic signaling pathway
Seon Min Woo and Taeg Kyu Kwon
BMB Reports 2019; 52(2): 119-126  https://doi.org/10.5483/BMBRep.2019.52.2.011
Epigenetic memory in gene regulation and immune response
Min Young Kim, Ji Eun Lee, Lark Kyun Kim and TaeSoo Kim
BMB Reports 2019; 52(2): 127-132  https://doi.org/10.5483/BMBRep.2019.52.2.257
Articles
OAS1 and OAS3 negatively regulate the expression of chemokines and interferon-responsive genes in human macrophages
Wook-Bin Lee, Won Young Choi, Dong-Hyun Lee, Hyeran Shim, Jeongsil Kim-Ha and Young-Joon Kim
BMB Reports 2019; 52(2): 133-138  https://doi.org/10.5483/BMBRep.2019.52.2.129
SETDB1 regulates SMAD7 expression for breast cancer metastasis
Tae Young Ryu, Kwangho Kim, Seon-Kyu Kim, Jung-Hwa Oh, Jeong-Ki Min, Cho-Rok Jung, Mi-Young Son, Dae-Soo Kim and Hyun-Soo Cho
BMB Reports 2019; 52(2): 139-144  https://doi.org/10.5483/BMBRep.2019.52.2.235
Endothelial dysfunction induces atherosclerosis: increased aggrecan expression promotes apoptosis in vascular smooth muscle cells
Sang-Min Kim Jae-Wan Huh, Eun-Young Kim, Min-Kyung Shin, Ji-Eun Park, Seong Who Kim, Wooseong Lee, Bongkun Choi & Eun-Ju Chang
BMB Reports 2019; 52(2): 145-150  https://doi.org/10.5483/BMBRep.2019.52.2.282
High expression of RAD51 promotes DNA damage repair and survival in KRAS-mutant lung cancer cells
Jinfang Hu, Zhiguo Zhang, Lei Zhao, Li Li, Wei Zuo and Lei Han
BMB Reports 2019; 52(2): 151-156  https://doi.org/10.5483/BMBRep.2019.52.2.213
PRR11 and SKA2 gene pair is overexpressed and regulated by p53 in breast cancer
Yitao Wang, Chunxue Zhang, Li Mai, Yulong Niu, Yingxiong Wang and Youquan Bu
BMB Reports 2019; 52(2): 157-162  https://doi.org/10.5483/BMBRep.2019.52.2.207

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February 2019
Volume 52
Issue 2

2017 SCI Impact Factor 3.085

BIOCHEMISTRY & MOLECULAR BIOLOGY 134/292

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