• Tau mis-splicing in the pathogenesis of neurodegenerative disorders

    Fig. 1. Tau protein isoforms in the human brain. Six tau isoforms are present in the human brain through different combinations of the splicing of exons 2, 3, and/or 10. The aspects of the N-terminal projection domain, N1 (green) and N2 (blue), are produced from exons 2 and 3, respectively. Exon 10 encodes the second aspect of the microtubule-binding repeat domain, R2 (red). Depending on the presence of the R2 domain, tau proteins become either 3R or 4R tau.
  • Dual function of MG53 in membrane repair and insulin signaling

    Fig. 1. MG53 function in cell membrane repair and insulin signaling. (A) MG53 contains 477 amino acids with RING (Really Interesting New Gene), B-box, and Coil-coil domain at the amino terminus, plus a SPRY domain at the carboxyl terminus. (B) MG53 participates in the nucleation of transport vesicles to sites of membrane injury. It binds to phosphatidylserine (PS) and undergoes oligomerization when the cell changes from reduced to oxidized environment at the injury site. Entry of extracellular Ca2+ enables fusion of vesicles for formation of a repair patch. (C) MG53 contains an E3 Ligase activity that facilitates the ubiquitination of IRS-1. The proteasome-mediated degradation of IRS-1 contributes to the regulation of insulin signaling in muscle cells.

BMB Rep. 2016; 49(8): 401~454
Perspectives
Epigenetic role of nuclear S6K1 in early adipogenesis
Sang Ah Yi, Jihoon Han & Jeung-Whan Han*
BMB Rep. 2016; 49(8): 401-402  

Mechanosensitive β-catenin signaling regulates lymphatic vascular development

Boksik Cha & R. Sathish Srinivasan,*
BMB Rep. 2016; 49(8): 403-404  
Invited Mini Reviews
Tau mis-splicing in the pathogenesis of neurodegenerative disorders
Sun Ah Park,*, Sang Il Ahn & Jean-Marc Gallo
BMB Rep. 2016; 49(8): 405-413  
Dual function of MG53 in membrane repair and insulin signaling
Tao Tan, Young-Gyu Ko,* & Jianjie Ma,*
BMB Rep. 2016; 49(8): 414-423  
Contributed Mini Review
Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy
You-Kyung Lee & Jin-A Lee*
BMB Rep. 2016; 49(8): 424-430  
Articles
Structural investigation on the intrinsically disordered N-terminal region of HPV16 E7 protein
Chewook Lee,#, Do-Hyoung Kim,#, Si-Hyung Lee, Jiulong Su & Kyou-Hoon Han,*
BMB Rep. 2016; 49(8): 431-436  
Critical role of protein L-isoaspartyl methyltransferase in basic fibroblast growth factor-mediated neuronal cell differentiation
To Thi Mai Dung,#, Young-Su Yi,#, Jieun Heo, Woo Seok Yang, Ji Hye Kim, Han Gyung Kim, Jae Gwang Park, Byong Chul Yoo, Jae Youl Cho,* & Sungyoul Hong,*
BMB Rep. 2016; 49(8): 437-442  
Ablation of Arg-tRNA-protein transferases results in defective neural tube development
Eunkyoung Kim, Seonmu Kim, Jung Hoon Lee, Yong Tae Kwon & Min Jae Lee,*
BMB Rep. 2016; 49(8): 443-448  
Identification of Neuregulin-2 as a novel stress granule component
Jin Ah Kim,#, Aravinth Kumar Jayabalan,#, Vinoth Kumar Kothandan, Ramesh Mariappan, Younghoon Kee & Takbum Ohn,*
BMB Rep. 2016; 49(8): 449-454  

e-submission

Current Issue

August 2016
Volume 49
Issue 8

2015 SCI Impact Factor 2.782

BIOCHEMISTRY & MOLECULAR BIOLOGY 138/289

Indexed/Covered by

Supported By