• Degradation or aggregation: the ramifications of post-translational modifications on tau

    Structural organization of tau isoforms. Six tau isoforms are encoded by the single MAPT gene. The shortest tau isoform is the 3R/0N (three repeats [R1, R3, and R4] in the microtubule binding domain and zero products from exon 2 and 3 [N1 and N2] in the N-domain) that contain 352 amino acids. The longest isoform of human tau is the 4R/2N with 441 amino acids. Exon 10 encodes the second repeat (R2) of the MBD. The expression of tau isoforms is differentially regulated by developmental stages and specific cell types/locations in the brain, and also possibly affected by the progression of tauopathies.
  • Mitochondria-mediated defense mechanisms against pathogens in Caenorhabditis elegans

    Mitochondrial surveillance and mitophagy contribute to immunity. Pyoverdine, a siderophore produced by Pseudomonas aeruginosa, binds and removes iron in hosts, triggering mitochondrial stress. Host mitochondrial surveillance mechanism detects mitochondrial stress and activates ESRE (Ethanol and Stress Response Element) gene network. The induction of ESRE-containing genes increases immunity. Reduced mitochondrial iron levels also induce mitophagy that enhances immunity, acting through autophagy machinery proteins, including PTEN-induced putative kinase 1 (PINK1), Beclin 1, and microtubule-associated protein light chain 3 (LC3).
  • Long noncoding RNA: multiple players in gene expression

    The regulation of lncRNAs in epigenetics. (A) LncRNA may recruit protein complexes as scaffold, deceive chromatin-remodeling components as decoy, and direct remodelers as guide. (B) LncRNA guides epigenetic modifiers to change the chromatin structure, histone methylation or acetylation level, and DNA methylation level.

BMB Reports 2018; 51(6): 261~314
Perspectives
Deubiquitinase USP35 as a novel mitotic regulator via maintenance of Aurora B stability
Jinyoung Park, and Eun Joo Song
BMB Reports 2018; 51(6): 261-262  https://doi.org/10.5483/BMBRep.2018.51.6.110
Osteoclast-derived SLIT3 is a coupling factor linking bone resorption to bone formation
Jung-Min Koh
BMB Reports 2018; 51(6): 263-264  https://doi.org/10.5483/BMBRep.2018.51.6.109
Invited Mini Reviews
Degradation or aggregation: the ramifications of post-translational modifications on tau
Seoyoung Park, Jung Hoon Lee, Jun Hyoung Jeon, and Min Jae Lee
BMB Reports 2018; 51(6): 265-273  https://doi.org/10.5483/BMBRep.2018.51.6.077
Mitochondria-mediated defense mechanisms against pathogens in Caenorhabditis elegans
Sujeong Kwon, Eun Ji E. Kim, and Seung-Jae V. Lee
BMB Reports 2018; 51(6): 274-279  https://doi.org/10.5483/BMBRep.2018.51.6.111
Contributed Mini Review
Long noncoding RNA: multiple players in gene expression
Xiaochang Chen, Yunmei Sun, Rui Cai, Guoqiang Wang, Xiaoyan Shu, and Weijun Pang
BMB Reports 2018; 51(6): 280-289  https://doi.org/10.5483/BMBRep.2018.51.6.025
Articles
Investigation of function and regulation of the YB-1 cellular factor in HIV replication
Yu-Mi Jung, Kyung-Lee Yu, Seong-Hyun Park, Seong-Deok Lee, Min-Jeong Kim, and Ji-Chang You
BMB Reports 2018; 51(6): 290-295  https://doi.org/10.5483/BMBRep.2018.51.6.231
Mitochondrial dysfunction suppresses p53 expression via calcium-mediated nuclear factor-kB signaling in HCT116 human colorectal carcinoma cells
Young-Kyoung Lee, Eui-Yeun Yi, Shi-Young Park, Won-Jun Jang, Yu-Seon Han, Myeong-Eun Jegal, and Yung-Jin Kim
BMB Reports 2018; 51(6): 296-301  https://doi.org/10.5483/BMBRep.2018.51.6.232
Pinosylvin exacerbates LPS-induced apoptosis via ALOX 15 upregulation in leukocytes
Ohseong Kwon, Youngsik Seo, and Heonyong Park
BMB Reports 2018; 51(6): 302-307  https://doi.org/10.5483/BMBRep.2018.51.6.024
Anti-inflammatory effects of a novel compound, MPQP, through the inhibition of IRAK1 signaling pathways in LPS-stimulated RAW 264.7 macrophages
Ba Reum Kim, Young-Chang Cho, and Sayeon Cho
BMB Reports 2018; 51(6): 308-313  https://doi.org/10.5483/BMBRep.2018.51.6.064
Erratum
Erratum to: PD-1 deficiency protects experimental colitis via alteration of gut microbiota
Seong Jeong Park, Ji-Hae Kim, Mi-Young Song, Young Chul Sung, Seung-Woo Lee & Yunji Park
BMB Reports 2018; 51(6): 314-314  

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Current Issue

June 2018
Volume 51
Issue 6

2017 SCI Impact Factor 3.085

BIOCHEMISTRY & MOLECULAR BIOLOGY 134/292

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