• Recent advances in organoid culture for insulin production and diabetes therapy: methods and challenges

    Step-wise protocol elucidating the endocrine differentiation of hESCs and the characterization of hESC-ECCs. (A) Experimental protocol outlining the stages, and inducing factors and chemicals for differentiation of hESCs into definitive endoderm (DE), pancreatic endoderm (PE), and endocrine progenitor (EP) cells and the final insulin-producing endocrine cells (EC). (B) Phase-contrast image of hESC-ECCs. Scale bar = 100 μm. (C) Immmunocytochemical analysis showing the expression of β cell-associated genes, endocrine hormone genes, and β cell function-linked proteins. Scale bar = 50 μm. The figure is reproduced from the article by Kim et al. 2016 (). This work is licensed under a Creative Commons Attribution 4.0 International License ().
  • Neuronal function and dysfunction of CYFIP2: from actin dynamics to early infantile epileptic encephalopathy

    Neuronal functions of CYFIP2 and potential effects of the Arg87 variants identified in the West syndrome on those functions. (A) The Arg87 variants weaken the inhibitory CYFIP2-VCA interaction, thereby leading to aberrant activation of WRC and the downstream actin polymerization. This may result in dendritic spine remodeling and change excitatory/inhibitory synaptic balance, in favor of more excitation. (B) Similar to CYFIP1, CYFIP2 may also regulate neurotransmitter release in the presynaptic compartment, and the Arg87 variants may affect this function of CYFIP2. (C) The WRC interacts with certain ion channels potentially involved in regulating neuronal excitability. Given that CYFIP and ABI of the WRC form an interaction surface toward those membrane proteins, the Arg87 variants may indirectly affect such interactions, thereby changing surface stability or other functional properties of ion channels. (D) In addition to the WRC, CYFIP2 also interacts with some mRNA-binding proteins, such as FMRP, to regulate target mRNA transport and local translation. The Arg87 variants may affect formation of these mRNA-regulatory protein complexes, or their function in regulating target mRNAs.

BMB Reports 2019; 52(5): 295~347
Invited Mini Reviews
Recent advances in organoid culture for insulin production and diabetes therapy: methods and challenges
Ahmed Abdal Dayem, Soo Bin Lee, Kyeongseok Kim, Kyung Min Lim, Tak-il Jeon & Ssang-Goo Cho
BMB Reports 2019; 52(5): 295-303  https://doi.org/10.5483/BMBRep.2019.52.5.089
Neuronal function and dysfunction of CYFIP2: from actin dynamics to early infantile epileptic encephalopathy
Yinhua Zhang, Yeunkum Lee & Kihoon Han
BMB Reports 2019; 52(5): 304-311  https://doi.org/10.5483/BMBRep.2019.52.5.097
Articless
MiR-371 promotes proliferation and metastasis in hepatocellular carcinoma by targeting PTEN
Hao Wang, Yi Zhao, Tingsong Chen, Guofang Liu, Nan He, and Heping Hu
BMB Reports 2019; 52(5): 312-317  https://doi.org/10.5483/BMBRep.2019.52.5.155
Interferon-γ-mediated secretion of tryptophanyl-tRNA synthetases has a role in protection of human umbilical cord blood-derived mesenchymal stem cells against experimental colitis
Insung Kang, Byung-Chul Lee, Jin Young Lee, Jae-Jun Kim, Seung-Eun Lee, Nari Shin, Soon Won Choi & Kyung-Sun Kang
BMB Reports 2019; 52(5): 318-323  https://doi.org/10.5483/BMBRep.2019.52.5.134
Enhanced delivery of protein fused to cell penetrating peptides to mammalian cells
Jung-Il Moon, Min-Joon Han, Shin-Hye Yu, Eun-Hye Lee, Sang-Mi Kim, Kyuboem Han, Chang-Hwan Park & Chun-Hyung Kim
BMB Reports 2019; 52(5): 324-329  https://doi.org/10.5483/BMBRep.2019.52.5.195
C-terminal truncated HBx reduces doxorubicin cytotoxicity via ABCB1 upregulation in Huh-7 hepatocellular carcinoma cells
Myeong-Eun Jegal, Seung-Youn Jung, Yu-Seon Han & Yung-Jin Kim
BMB Reports 2019; 52(5): 330-335  https://doi.org/10.5483/BMBRep.2019.52.5.312
Induction of pro-inflammatory cytokines by 29-kDa FN-f via cGAS/STING pathway
Hyun Sook Hwang, Mi Hyun Lee, Min Ha Choi & Hyun Ah Kim
BMB Reports 2019; 52(5): 336-341  https://doi.org/10.5483/BMBRep.2019.52.5.072
Enhanced anticancer effects of a methylation inhibitor by inhibiting a novel DNMT1 target, CEP 131, in cervical cancer
Dong Hyun Kim, Hye-Min Kim, Pham Thi Thu Huong, Ho-Jin Han, Joonsung Hwang, Hyunjoo Cha-Molstad, Kyung Ho Lee, In-Ja Ryoo, Kyoon Eon Kim, Yang Hoon Huh, Jong Seog Ahn, Yong Tae Kwon, Nak-Kyun Soung & Bo Yeon Kim
BMB Reports 2019; 52(5): 342-347  https://doi.org/10.5483/BMBRep.2019.52.5.055

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May 2019
Volume 52
Issue 5

2017 SCI Impact Factor 3.085

BIOCHEMISTRY & MOLECULAR BIOLOGY 134/292

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