• Upstream signalling of mTORC1 and its hyperactivation in type 2 diabetes (T2D)

    mTOR signaling pathway and its upstream elements. Amino acids, glucose, fatty acids, Wnt ligand, growth factors, hormones, stresses, energy status, and oxygen are key factors that affect mTORC1 activity. Upon activation, mTORC1 facilitates the synthesis of protein, lipids, and energy metabolism. It inhibits autophagy.

BMB Reports 2017; 50(12): 597~646
Perspectives
CoMIC, the hidden dynamics of mitochondrial inner compartments
Bongki Cho, and Woong Sun
BMB Reports 2017; 50(12): 597-598  https://doi.org/10.5483/BMBRep.2017.50.12.154
Pro-tumorigenic roles of TGF-β signaling during the early stages of liver tumorigenesis through upregulation of Snail
Hyuk Moon, Kwang-Hyub Han, and Simon Weonsang Ro
BMB Reports 2017; 50(12): 599-600  https://doi.org/10.5483/BMBRep.2017.50.12.201
Invited Mini Reviews
Upstream signalling of mTORC1 and its hyperactivation in type 2 diabetes (T2D)
Muhammad Ali, Shazia Anwer Bukhari, Muhammad Ali, and Han-Woong Lee
BMB Reports 2017; 50(12): 601-609  https://doi.org/10.5483/BMBRep.2017.50.12.206
Promoting and improving three Rs practice: the Korean guidelines
Byung In Choe, and Gwi Hyang Lee
BMB Reports 2017; 50(12): 610-614  https://doi.org/10.5483/BMBRep.2017.50.12.225
Articles
Fibronectin expression is upregulated by PI-3K/Akt activation in tamoxifen-resistant breast cancer cells
Daeun You, Seung Pil Jung, Yisun Jeong, Soo Youn Bae, Jeong Eon Lee, and Sangmin Kim
BMB Reports 2017; 50(12): 615-620  https://doi.org/10.5483/BMBRep.2017.50.12.096
Zinc finger protein 143 expression is closely related to tumor malignancy via regulating cell motility in breast cancer
A Rome Paek, Ji Young Mun, Kyeong-Man Hong, Jongkeun Lee, Dong Wan Hong, and Hye Jin You
BMB Reports 2017; 50(12): 621-627  https://doi.org/10.5483/BMBRep.2017.50.12.177
Gastrin-releasing peptide promotes the migration of vascular smooth muscle cells through upregulation of matrix metalloproteinase-2 and -9
Hyun-Joo Park, Mi-Kyoung Kim, Yeon Kim, Sun Sik Bae, Hyung Joon Kim, Soo-Kyung Bae, and Moon-Kyoung Bae
BMB Reports 2017; 50(12): 628-633  https://doi.org/10.5483/BMBRep.2017.50.12.158
Anti-inflammatory and anti-oxidative effects of 3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride on β-amyloid-induced microglial activation
Seung-Ju Yang, Jiae Kim, Sang Eun Lee, Jee-Yin Ahn, Soo Young Choi, and Sung-Woo Cho
BMB Reports 2017; 50(12): 634-639  https://doi.org/10.5483/BMBRep.2017.50.12.189
JQ1, a BET inhibitor, controls TLR4-induced IL-10 production in regulatory B cells by BRD4-NF-κB axis
Min Bum Lee, Jun-Ho Lee, Seong Hwi Hong, Jueng Soo You, Seung Taek Nam, Hyun Woo Kim, Young Hwan Park, Dajeong Lee, Keun Young Min, Yeong-Min Park, Young Mi Kim, Hyuk Soon Kim, and Wahn Soo Choi
BMB Reports 2017; 50(12): 640-646  https://doi.org/10.5483/BMBRep.2017.50.12.194
Erratum
Erratum to: Potentiation of TRAIL killing activity by multimerization through isoleucine zipper hexamerization motif
Ji Hye Han, Ae Ran Moon, Jeong Hwan Chang, Jeehyeon Bae, Jin Myung Choi, Sung Haeng Lee & Tae-Hyoung Kim,*
BMB Reports 2017; 50(12): 647  

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December 2017
Volume 50
Issue 12

2016 SCI Impact Factor 3.089

BIOCHEMISTRY & MOLECULAR BIOLOGY 138/289

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