• Cancer stem cell surface markers on normal stem cells

    Proposed strategy for the identification of novel CSC surface markers by using hESCs/hPSCs-specific MAbs. Shown is an overall scheme showing a normal cellular hierarchy of embryonic stem cells (hESCs/hPSCs), adult stem cells, and differentaited normal tissue cells. Cancer stem cells can be derived from hESCs/hPSCs, adult stem cells and normal tissues cells. MAbs specific to undifferentiated hESCs/hPSCs, but not to adult stem cells and normal tissue cells, will be attractive tools to discover novel CSC surface markers, since the antigens recognized by the MAbs is highly likely to be present on CSCs, but not on normal tissue cells, in adults.
  • Emerging role of mitophagy in human diseases and physiology

    The role of mitophagy in normal physiology and human disease. Mitophagy plays an important role in maintaining mitochondria homeostasis and various aspects of cellular function. These roles are critical to prevent developing human diseases and aging-related dysfunctions.
  • Clinical significance linked to functional defects in bone morphogenetic protein type 2 receptor, BMPR2

    Schematic summary of BMPR2 and its associated proteins in the BMP-mediated signaling cascade. Different BMP ligands engage BMPR2 and different corresponding type 1 receptors, such as ACVR1, BMPR1a, BMPR1b and ALK1. BMP4 and BMP6 ligands bind to a receptor complex consisting of BMPR2 and ACVR1; BMP2, BMP4, and BMP6 bind to BMPR2 and BMPR1a; BMP2 and BMP4 bind to BMPR2 and BMPR1b; and BMP9 and BMP10 bind to BMPR2 and ALK1. The activity of ACVR1 is negatively regulated by interaction with FKBP12. Endoglin, as a co-receptor for ALK1, promotes the receptor complex formation. Engagement of BMP ligands triggers SMAD1/5/8 phosphorylation, which then binds to SMAD4. The SMAD complex translocates into the nucleus to induce target gene expression. SMAD6 and SMAD7, which are induced by BMP signaling, bind to type 1 receptors and thus, negatively regulate BMP signaling by negative feedback loop. Some of the BMP target genes, including ID proteins, are indicated. MAPK, LIMK, ROCK, and Rho are activated by SMAD protein-independent manner.

BMB Reports 2017; 50(6): 281~341
Perspectives
Deubiquitinase YOD1: the potent activator of YAP in hepatomegaly and liver cancer
Youngeun Kim, and Eek-hoon Jho
BMB Reports 2017; 50(6): 281-282  https://doi.org/10.5483/BMBRep.2017.50.6.078
Single-cell RNA-Seq unveils tumor microenvironment
Hae-Ock Lee, and Woong-Yang Park
BMB Reports 2017; 50(6): 283-284  https://doi.org/10.5483/BMBRep.2017.50.6.086
Invited Mini Reviews
Cancer stem cell surface markers on normal stem cells
Won-Tae Kim, and Chun Jeih Ryu
BMB Reports 2017; 50(6): 285-298  https://doi.org/10.5483/BMBRep.2017.50.6.039
Emerging role of mitophagy in human diseases and physiology
Jee-Hyun Um, and Jeanho Yun
BMB Reports 2017; 50(6): 299-307  https://doi.org/10.5483/BMBRep.2017.50.6.056
Clinical significance linked to functional defects in bone morphogenetic protein type 2 receptor, BMPR2
Myung-Jin Kim, Seon Young Park, Hae Ryung Chang, Eun Young Jung, Anudari Munkhjargal, Jong-Seok Lim, Myeong-Sok Lee, and Yonghwan Kim
BMB Reports 2017; 50(6): 308-317  https://doi.org/10.5483/BMBRep.2017.50.6.059
Articles
Identifying the cellular location of brain cytoplasmic 200 RNA using an RNA-recognizing antibody
Heegwon Shin, Jungmin Lee, Youngmi Kim, Seonghui Jang, Takbum Ohn, and Younghoon Lee
BMB Reports 2017; 50(6): 318-322  https://doi.org/10.5483/BMBRep.2017.50.6.217
Effects of chlorogenic acid on intracellular calcium regulation in lysophosphatidylcholine-treated endothelial cells
Hye-Jin Jung, Seung-Soon Im, Dae-Kyu Song, and Jae-Hoon Bae
BMB Reports 2017; 50(6): 323-328  https://doi.org/10.5483/BMBRep.2017.50.6.182
Inhibition of protein tyrosine phosphatase non-receptor type 2 by PTP inhibitor XIX: Its role as a multiphosphatase inhibitor
Hien Thi Thu Le, Young-Chang Cho, and Sayeon Cho
BMB Reports 2017; 50(6): 329-334  https://doi.org/10.5483/BMBRep.2017.50.6.003
Chronophin activation is necessary in Doxorubicin-induced actin cytoskeleton alteration
Su Jin Lee, Jeen Woo Park, Beom Sik Kang, Dong-Seok Lee, Hyun-Shik Lee, Sooyoung Choi, and Oh-Shin Kwon
BMB Reports 2017; 50(6): 335-340  https://doi.org/10.5483/BMBRep.2017.50.6.061
Erratum

Erratum to: Ganglioside GM1 influences the proliferation rate of mouse induced pluripotent stem cells

Jae-Sung Ryu, Kyu-Tae Chang, Ju-Taek Lee, Malg-Um Lim, Hyun-Ki Min, Yoon-Ju Na, Su-Bin Lee, Gislain Moussavou, Sun-Uk Kim, Ji-Su Kim, Kinarm Ko, Kisung Ko, Kyung-A Hwang, Eun-Jeong Jeong, Jeong-Woong Lee,* & Young-Kug Choo,*
BMB Reports 2017; 50(6): 341-341  

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June 2017
Volume 50
Issue 6

2016 SCI Impact Factor 3.089

BIOCHEMISTRY & MOLECULAR BIOLOGY 138/289

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