• Dual TORCs driven and B56 orchestrated signaling network guides eukaryotic cell migration

    Protein phosphatase 2A is comprised of three components: the catalytic C, the scaffolding A, and the regulatory B subunits. Structural and bioinformatics analysis unveiled that B56, one of the B subunits, binds to its target either through the central region or the C-terminal edge of the pseudo heat domain. The central region recognize B56 targets that contain LxxIxE motif (, ), whereas the C-terminal end region binds to distinct type of target such as Shugoshin (). Number of B56 genes in yeast, fungi, protist, plants, and human is shown. A single B56 gene exists in Dictyostelium discoideum. PTPA and PTPB is competing with the regulatory B subunits to associate with the AC core dimer (i). TorC1/TAP42 inhibits the PP2A catalytic activity (ii). Src tyrosine kinase phosphorylates and inhibits the catalytic PP2A subunit (iii). TorC2/PKA signaling axis activates B56/PP2A (iv) whereas Protein Kinase C and ERK1/2 phosphorylate and inhibit B56 (v and vi).
  • Functional roles of CTCF in breast cancer

    The multiple functions of CTCF in breast cancer cells. (A) CTCF as transcriptional regulator regulates target gene expression through binding with co-factors such as ER and TP53 at unmethylated CpG regions. (B) CTCF as insulator prevents enhancer activity through regulation of ER binding to neighboring genes, TFF3 and TMPRSS3, at the TFF locus. (C) CTCF is involved in inverse expression of genes which have alternative promoters. After ER treatment, long-form transcript of NET1 was highly expressed whereas short-form transcript separated by CTCF was decreased. (D) Decreased CTCF after ER treatment induces chromatin looping to connect distal and proximal ERs at the P2RY2 locus.

BMB Reports 2017; 50(9): 435~483
Suppression of SIRT2 and altered acetylation status of human pluripotent stem cells: possible link to metabolic switch during reprogramming
Ok-Seon Kwon, Min-Joon Han, and Hyuk-Jin Cha
BMB Reports 2017; 50(9): 435-436  https://doi.org/10.5483/BMBRep.2017.50.9.119
Invited Mini Reviews
Dual TORCs driven and B56 orchestrated signaling network guides eukaryotic cell migration
Lou W. Kim
BMB Reports 2017; 50(9): 437-444  https://doi.org/10.5483/BMBRep.2017.50.9.091
Functional roles of CTCF in breast cancer
Sumin Oh, Chaeun Oh, and Kyung Hyun Yoo
BMB Reports 2017; 50(9): 445-453  https://doi.org/10.5483/BMBRep.2017.50.9.108
Tusc2/Fus1 regulates osteoclast differentiation through NF-κB and NFATc1
Inyoung Kim, Jung Ha Kim, Kabsun Kim, Semun Seong, and Nacksung Kim
BMB Reports 2017; 50(9): 454-459  https://doi.org/10.5483/BMBRep.2017.50.9.026
Effects of PEP-1-FK506BP on cyst formation in polycystic kidney disease
Hyo Sang Jo, Won Sik Eum, Eun Young Park, Je Young Ko, Do Yeon Kim, Dae Won Kim, Min Jea Shin, Ora Son, Su Bin Cho, Jung Hwan Park, Chi Hern Lee, Eun Ji Yeo, Hyeon Ji Yeo, Yeon Joo Choi, Jong Kyu Youn, Sung-Woo Cho, Jinseu Park, Jong Hoon Park, and Soo Young Choi
BMB Reports 2017; 50(9): 460-465  https://doi.org/10.5483/BMBRep.2017.50.9.090
Identification of simvastatin-regulated targets associated with JNK activation in DU145 human prostate cancer cell death signaling
Eun Joo Jung, Ky Hyun Chung, and Choong Won Kim
BMB Reports 2017; 50(9): 466-471  https://doi.org/10.5483/BMBRep.2017.50.9.087
Bach2 represses the AP-1-driven induction of interleukin-2 gene transcription in CD4+ T cells
Eunkyeong Jang, Hye Rim Lee, Geon Hee Lee, Ah-Reum Oh, Ji-Young Cha, Kazuhiko Igarashi, and Jeehee Youn
BMB Reports 2017; 50(9): 472-477  https://doi.org/10.5483/BMBRep.2017.50.9.124
Heterogeneous interaction network of yeast prions and remodeling factors detected in live cells
Chan-Gi Pack, Yuji Inoue, Takashi Higurashi, Shigeko Kawai-Noma, Daigo Hayashi, Elizabeth Craig, and Hideki Taguchi
BMB Reports 2017; 50(9): 478-483  https://doi.org/10.5483/BMBRep.2017.50.9.084


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September 2017
Volume 50
Issue 9

2016 SCI Impact Factor 3.089


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