• Recent advances in organoid culture for insulin production and diabetes therapy: methods and challenges

    Step-wise protocol elucidating the endocrine differentiation of hESCs and the characterization of hESC-ECCs. (A) Experimental protocol outlining the stages, and inducing factors and chemicals for differentiation of hESCs into definitive endoderm (DE), pancreatic endoderm (PE), and endocrine progenitor (EP) cells and the final insulin-producing endocrine cells (EC). (B) Phase-contrast image of hESC-ECCs. Scale bar = 100 μm. (C) Immmunocytochemical analysis showing the expression of β cell-associated genes, endocrine hormone genes, and β cell function-linked proteins. Scale bar = 50 μm. The figure is reproduced from the article by Kim et al. 2016 (). This work is licensed under a Creative Commons Attribution 4.0 International License ().
  • Neuronal function and dysfunction of CYFIP2: from actin dynamics to early infantile epileptic encephalopathy

    Neuronal functions of CYFIP2 and potential effects of the Arg87 variants identified in the West syndrome on those functions. (A) The Arg87 variants weaken the inhibitory CYFIP2-VCA interaction, thereby leading to aberrant activation of WRC and the downstream actin polymerization. This may result in dendritic spine remodeling and change excitatory/inhibitory synaptic balance, in favor of more excitation. (B) Similar to CYFIP1, CYFIP2 may also regulate neurotransmitter release in the presynaptic compartment, and the Arg87 variants may affect this function of CYFIP2. (C) The WRC interacts with certain ion channels potentially involved in regulating neuronal excitability. Given that CYFIP and ABI of the WRC form an interaction surface toward those membrane proteins, the Arg87 variants may indirectly affect such interactions, thereby changing surface stability or other functional properties of ion channels. (D) In addition to the WRC, CYFIP2 also interacts with some mRNA-binding proteins, such as FMRP, to regulate target mRNA transport and local translation. The Arg87 variants may affect formation of these mRNA-regulatory protein complexes, or their function in regulating target mRNAs.

BMB Reports 2019; 52(6): 349~414
Invited Mini Reviews
Patient-specific pluripotent stem cell-based Parkinson’s disease models showing endogenous alpha-synuclein aggregation
Yohan Oh
BMB Reports 2019; 52(6): 349-359  https://doi.org/10.5483/BMBRep.2019.52.6.142
Metabolic influence on macrophage polarization and pathogenesis
Bikash Thapa, and Keunwook Lee
BMB Reports 2019; 52(6): 360-372  https://doi.org/10.5483/BMBRep.2019.52.6.140
NOD2 signaling pathway is involved in fibronectin fragment-induced pro-catabolic factor expressions in human articular chondrocytes
Hyun Sook Hwang, Mi Hyun Lee, Min Ha Choi, and Hyun Ah Kim
BMB Reports 2019; 52(6): 373-378  https://doi.org/10.5483/BMBRep.2019.52.6.165
TP53I11 suppresses epithelial-mesenchymal transition and metastasis of breast cancer cells
Tongqian Xiao, Zhongjuan Xu, Hai Zhang, Junsa Geng, Yong Qiao, Yu Liang, Yanzhen Yu, Qun Dong, and Guangli Suo
BMB Reports 2019; 52(6): 379-384  https://doi.org/10.5483/BMBRep.2019.52.6.173
Leptin stimulates IGF-1 transcription by activating AP-1 in human breast cancer cells
Dong Yeong Min, Euitaek Jung, Juhwan Kim, Young Han Lee, and Soon Young Shin
BMB Reports 2019; 52(6): 385-390  https://doi.org/10.5483/BMBRep.2019.52.6.189
CCAAT/enhancer-binding protein beta (C/EBPβ) is an important mediator of 1,25 dihydroxyvitamin D3 (1,25D3)-induced receptor activator of nuclear factor kappa-B ligand (RANKL) expression in osteoblasts
Sungsin Jo, Yun Young Lee, Jinil Han, Young Lim Lee, Subin Yoon, Jaehyun Lee, Younseo Oh, Joong-Soo Han, Il-Hoon Sung, Ye-Soo Park, and Tae-Hwan Kim
BMB Reports 2019; 52(6): 391-396  https://doi.org/10.5483/BMBRep.2019.52.6.166
Generation and characterization of a monoclonal antibody against MERS-CoV targeting the spike protein using a synthetic peptide epitope-CpG-DNA-liposome complex
Byoung Kwon Park, Sony Maharjan, Su In Lee, Jinsoo Kim, Joon-Yong Bae, Man-Seong Park, and Hyung-Joo Kwon
BMB Reports 2019; 52(6): 397-402  https://doi.org/10.5483/BMBRep.2019.52.6.185
Ventx1.1 competes with a transcriptional activator Xcad2 to regulate negatively its own expression
Shiv Kumar, Zobia Umair, Vijay Kumar, Unjoo Lee, Sun-Cheol Choi, and Jaebong Kim
BMB Reports 2019; 52(6): 403-408  https://doi.org/10.5483/BMBRep.2019.52.6.085
2-O-digalloyl-1,3,4,6-tetra-O-galloyl-β-D-glucose isolated from Galla Rhois suppresses osteoclast differentiation and function by inhibiting NF-κB signaling
Hye Jung Ihn, Tae Hoon Kim, Kiryeong Kim, Gi-Young Kim, You-Jin Jeon, Yung Hyun Choi, Jong-Sup Bae, Jung-Eun Kim, and Eui Kyun Park
BMB Reports 2019; 52(6): 409-414  https://doi.org/10.5483/BMBRep.2019.52.6.063


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June 2019
Volume 52
Issue 6

2018 SCI Impact Factor 2.966


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