• Cancer stem cell metabolism: target for cancer therapy

    Fig. 1. Impact of CSCs on the effectiveness of anticancer therapy. CSCs are a small sub population of bulk tumor cells that are highly chemo-resistant and play a prominent role in tumor relapse. While conventional therapy results in a transient reduction in the tumor by killing non-stem cancer cells (differentiated cancer cells), the remaining CSCs can form recurring tumors, and metastasis is induced by the formation of a secondary colony in distant organs. The use of CSC-specific inhibitors would reduce therapy resistance and relapse, and prevent metastasis, with a loss of stem cell properties.
  • Laminopathies; Mutations on single gene and various human genetic diseases

    Fig. 1. Structure of LMNA gene. LMNA, encoding Lamin A/C is composed of 12 exons and the two produced proteins, Lamin A and Lamin C. Exon 1-10 are commonly used for Lamin A and C proteins. However, exon 11 and 12 are only used by Lamin A. Since the end of exon 12 encodes CaaX motif (actually CSIM), only Lamin A is a target for farnesyl-transferase. In addition, the Zmpste24 protease target sequence is located in exon 11. Thus, Farnesylated Lamin A (prelamin A) is processed into mature Lamin A. Lamin C is produced by Exon 1-10 differentially from Lamin A. However, the final exon is differentially used from lamin by alternative splicing (dark blue box in middle panel). Consequently, the six C-terminal amino acids (VSGSRR; dark blue box) are uniquely derived from Lamin A. We also showed the structural domains of Lamin A/C.

BMB Reports 2018; 51(7): 315~367
Perspectives

Application of genome engineering for treatment of retinal diseases

Dong Hyun Jo & Jeong Hun Kim
BMB Reports 2018; 51(7): 315-316  https://doi.org/10.5483/BMBRep.2018.51.7.130
Cellular coordination controlling organ separation and surface integrity in plants
Yuree Lee & June M. Kwak
BMB Reports 2018; 51(7): 317-318  https://doi.org/10.5483/BMBRep.2018.51.7.142
Invited Mini Reviews
Cancer stem cell metabolism: target for cancer therapy
Young Chan Chae & Jae Ho Kim
BMB Reports 2018; 51(7): 319-326  https://doi.org/10.5483/BMBRep.2018.51.7.112
Laminopathies; Mutations on single gene and various human genetic diseases
So-mi Kang, Min-Ho Yoon & Bum-Joon Park*
BMB Reports 2018; 51(7): 327-337  https://doi.org/10.5483/BMBRep.2018.51.7.113
Articles
Investigation of functional roles of transcription termination factor-1 (TTF-I) in HIV-1 replication
Seong-Hyun Park, Kyung-Lee Yu, Yu-Mi Jung, Seong-Deok Lee, Min-Jeong Kim & Ji-Chang You
BMB Reports 2018; 51(7): 338-343  https://doi.org/10.5483/BMBRep.2018.51.7.032
Superoxide dismutase 3 protects mesenchymal stem cells through enhanced autophagy and regulation of FoxO3a trafficking
Gaurav Agrahari#, Shyam Kishor Sah# & Tae-Yoon Kim*
BMB Reports 2018; 51(7): 344-349  https://doi.org/10.5483/BMBRep.2018.51.7.078
The multifunctional RNA-binding protein hnRNPK is critical for the proliferation and differentiation of myoblasts
Yongjie Xu, Rui Li, Kaili Zhang, Wei Wu, Suying Wang, Pengpeng Zhang* & Haixia Xu*
BMB Reports 2018; 51(7): 350-355  https://doi.org/10.5483/BMBRep.2018.51.7.043
Actin-binding LIM protein 1 regulates receptor activator of NF-κB ligand-mediated osteoclast differentiation and motility
Su Hyun Jin, Hyunsoo Kim, Dong Ryun Gu, Keun Ha Park, Young Rae Lee, Yongwon Choi & Seoung Hoon Lee
BMB Reports 2018; 51(7): 356-361  https://doi.org/10.5483/BMBRep.2018.51.7.106
Protective effects of Tat-DJ-1 protein against streptozotocin-induced diabetes in a mice model
Hyeon Ji Yeo, Eun Ji Yeo, Min Jea Shin, Yeon Joo Choi, Chi Hern Lee, Hyeok Yil Kwon, Dae Won Kim, Won Sik Eum & Soo Young Choi
BMB Reports 2018; 51(7): 362-367  https://doi.org/10.5483/BMBRep.2018.51.7.101

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July 2018
Volume 51
Issue 7

2017 SCI Impact Factor 3.085

BIOCHEMISTRY & MOLECULAR BIOLOGY 134/292

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