• Synapses in neurodegenerative diseases

    Summarization of diagram for alteration of presynaptic terminals in various neurodegenerative diseases.
  • CRISPR system for genome engineering: the application for autophagy study

    Schematic diagram of the mammalian autophagy core machinery and CRISPR/Cas9 targeted genes. The Atg proteins form several important functional groups in control of autophagosome formation. (i) The ULK1 complex, consisting of the serine/threonine kinase ULK1, ATG13, focal adhesion kinase family interacting protein of 200 kDa (FIP200) and ATG101, controls the induction or initiation of autophagy for the formation of phagophore and is negatively regulated by mechanistic target of rapamycin (mTOR). (ii) The Beclin 1-class III PI3K complex controls the nucleation step of autophagosome formation. (iii) The two ubiquitin-like conjugation systems (the ATG12-ATG5 system and the LC3 system) mediate the elongation stage, leading to formation of a complete autophagosome. And (iv) The ATG9 retrieval process functionally involves a protein complex of WIPI1/2 and ATG2. The CRISPR targeted genes () in the autophagy core machinery in this review was indicated by an asterisk (*).

BMB Reports 2017; 50(5): 233~280
Perspectives
Role of GALNT14 in lung metastasis of breast cancer
Mi-Young Kim
BMB Reports 2017; 50(5): 233-234  https://doi.org/10.5483/BMBRep.2017.50.5.055
A chaperone surveillance system in plant circadian rhythms
Joon-Yung Cha, Laila Khaleda, Hee Jin Park, and Woe-Yeon Kim
BMB Reports 2017; 50(5): 235-236  https://doi.org/10.5483/BMBRep.2017.50.5.064
Invited Mini Reviews
Synapses in neurodegenerative diseases
Jae Ryul Bae, and Sung Hyun Kim
BMB Reports 2017; 50(5): 237-246  https://doi.org/10.5483/BMBRep.2017.50.5.038
CRISPR system for genome engineering: the application for autophagy study
Jianzhou Cui, Shirley Jia Li Chew, Yin Shi, Zhiyuan Gong, and Han-Ming Shen
BMB Reports 2017; 50(5): 247-256  https://doi.org/10.5483/BMBRep.2017.50.5.044
Articles
HSV-1 ICP27 induces apoptosis by promoting Bax translocation to mitochondria through interacting with 14-3-3θ
Ji Ae Kim, Jin Chul Kim, Jung Sun Min, Inho Kang, Jeongho Oh, and Jeong Keun Ahn
BMB Reports 2017; 50(5): 257-262  https://doi.org/10.5483/BMBRep.2017.50.5.023
Neoagarohexaose-mediated activation of dendritic cells via Toll-like receptor 4 leads to stimulation of natural killer cells and enhancement of antitumor immunity
Moon Hee Lee, Jong-Hwa Jang, Gun Young Yoon, Seung Jun Lee, Min-Goo Lee, Tae Heung Kang, Hee Dong Han, Hyuk Soon Kim, Wahn Soo Choi, Won Sun Park, Yeong-Min Park, and In Duk Jung
BMB Reports 2017; 50(5): 263-268  https://doi.org/10.5483/BMBRep.2017.50.5.014
Structural characterization of As-MIF and hJAB1 during the inhibition of cell-cycle regulation
Young-Hoon Park, Mi Suk Jeong, Ki-Tae Ha, Hak Sun Yu, and Se Bok Jang
BMB Reports 2017; 50(5): 269-274  https://doi.org/10.5483/BMBRep.2017.50.5.201
HSV-1 ICP27 represses NF-κB activity by regulating Daxx sumoylation
Ji Ae Kim, Mi Sun Choi, Jung Sun Min, Inho Kang, Jeongho Oh, Jin Chul Kim, and Jeong Keun Ahn
BMB Reports 2017; 50(5): 275-280  https://doi.org/10.5483/BMBRep.2017.50.5.010

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May 2017
Volume 50
Issue 5

2016 SCI Impact Factor 3.089

BIOCHEMISTRY & MOLECULAR BIOLOGY 138/289

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