• Two distinct nodes of translational inhibition in the Integrated Stress Response

    The Integrated Stress Response. There are four known stress-responsive eIF2α kinases that can impact global translation: PERK, GCN2, PKR and HRI. Phosphorylation of eIF2α results in the disassembly of the eIF2 complex, and thus reduced availability of initiator methionine (Met-tRNAiMet). While this attenuates translation of most transcripts, a small subset of stress-responsive transcripts such as ATF4 is paradoxically synthesized. ATF4 subsequently induces the transcription of various stress response genes.
  • DNA methylation-based age prediction from various tissues and body fluids

    Schematic representation of epigenetic drift versus the epigenetic clock. If a specific CpG site is associated with age (top) within an individual, it may be undergoing either epigenetic drift (left) or an epigenetic clock site (right). Both phenomena have different characteristics when examined across a population or within a twin set. Reprinted from Jones et al. () with permission from John Wiley & Sons Ltd. and The Anatomical Society.
  • Invited Mini Review  30 November 2017

    Rules for functional microRNA targeting

    MicroRNAs (miRNAs) are ~22nt-long single-stranded RNA molecules that form a RNA-induced silencing complex with Argonaute (AGO) protein to post-transcriptionally downregulate their target messenger RNAs (mRNAs). To understand the regulatory mechanisms of miRNA, discovering the underlying functional rules for how miRNAs recognize and repress their target mRNAs is of utmost importance. To determine functional miRNA targeting rules, previous studies extensively utilized various methods including ...


BMB Reports 2017; 50(11): 535~595
Perspectives
Human-yeast genetic interaction for disease network: systematic discovery of multiple drug targets
Kyoungho Suk
BMB Reports 2017; 50(11): 535-536  https://doi.org/10.5483/BMBRep.2017.50.11.118
Hypoxia suffocates histone demethylases to change gene expression: a metabolic control of histone methylation
Hyunsung Park
BMB Reports 2017; 50(11): 537-538  https://doi.org/10.5483/BMBRep.2017.50.11.200
Invited Mini Reviews
Two distinct nodes of translational inhibition in the Integrated Stress Response
Hyung Don Ryoo, and Deepika Vasudevan
BMB Reports 2017; 50(11): 539-545  https://doi.org/10.5483/BMBRep.2017.50.11.157
DNA methylation-based age prediction from various tissues and body fluids
Sang-Eun Jung, Kyoung-Jin Shin, and Hwan Young Lee
BMB Reports 2017; 50(11): 546-553  https://doi.org/10.5483/BMBRep.2017.50.11.175
Rules for functional microRNA targeting
Doyeon Kim, Hee Ryung Chang, and Daehyun Baek
BMB Reports 2017; 50(11): 554-559  https://doi.org/10.5483/BMBRep.2017.50.11.179
Articles
Cytoprotective effect exerted by geraniin in HepG2 cells is through microRNA mediated regulation of BACH-1 and HO-1
Hoda Aayadi, Smriti P.K. Mittal, Anjali Deshpande, Makarand Gore, and Saroj S. Ghaskadbi
BMB Reports 2017; 50(11): 560-565  https://doi.org/10.5483/BMBRep.2017.50.11.060
Kahweol inhibits lipid accumulation and induces Glucose-uptake through activation of AMP-activated protein kinase (AMPK)
Jung-Hwan Baek, Nam-Jun Kim, Jun-Kyu Song, and Kyung-Hee Chun
BMB Reports 2017; 50(11): 566-571  https://doi.org/10.5483/BMBRep.2017.50.11.031
Antioxidant effects of selenocysteine on replicative senescence in human adipose-derived mesenchymal stem cells
Nayoung Suh, and Eun-bi Lee
BMB Reports 2017; 50(11): 572-577  https://doi.org/10.5483/BMBRep.2017.50.11.174
PD-1 deficiency protects experimental colitis via alteration of gut microbiota
Seong Jeong Park, Ji-Hae Kim, Mi-Young Song, Young Chul Sung, Seung-Woo Lee, and Yunji Park
BMB Reports 2017; 50(11): 578-583  https://doi.org/10.5483/BMBRep.2017.50.11.165
Protein tyrosine phosphatase PTPN21 acts as a negative regulator of ICAM-1 by dephosphorylating IKKβ in TNF-α-stimulated human keratinocytes
Young-Chang Cho, Ba Reum Kim, and Sayeon Cho
BMB Reports 2017; 50(11): 584-589  https://doi.org/10.5483/BMBRep.2017.50.11.169
Identification of specifically activated angiogenic molecules in HMGB-1-induced angiogenesis
Won Kyu Kim, Yujin Kwon, Minhee Park, Seongju Yun, Ja-Young Kwon, and Hoguen Kim
BMB Reports 2017; 50(11): 590-595  https://doi.org/10.5483/BMBRep.2017.50.11.129

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November 2017
Volume 50
Issue 11

2016 SCI Impact Factor 3.089

BIOCHEMISTRY & MOLECULAR BIOLOGY 138/289

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