• A concise review of human brain methylome during aging and neurodegenerative diseases

    DNA methylation and its consequences. (A) DNA methylation and TET mediated DNA demethylation. Cytosine (C) is methylated at 5th carbon of the pyrimidine ring by DNA methyltransferases (DNMT) to form 5-methylcytosine (5-mC). Ten-Eleven Translocation (TET1-3) enzymes sequentially act on 5mC to generate 5 hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC), and finally 5-carboxylcytosine (5-caC). The 5fC and 5caC are excised directly by thymine DNA glycosylase (TDG). The resulting abasic sites, which are generated by TDG since it has the ability to catalyze the glycosidic bond between the base and deoxyribose sugar of DNA, are eventually replaced with unmethylated cytosines by base excision repair (BER). (B) Relationship between SNP, CpG site, eQTLs, mQTLs, and neurodegenerative diseases. Genome-Wide Association Studies (GWAS) have identified several Single-Nucleotide Polymorphisms (SNPs) which indicate differences in the inheritance of diseases. The single base pair changes in the DNA sequence can affect the gene expression levels and referred to as expression quantitative trait loci (eQTLs). Methylation quantitative trait loci (meQTLs) are the individual DNA sequence variation at specific loci that can cause changes in DNA methylation patterns of CpG sites. Significant correlation of methylation mark with gene expression is termed as expression Quantitative Trait Methylations (eQTMs). Recent studies have shown that eQTLs, meQTLs, and eQTMS are linked with neurodegenerative diseases. (C) Differential CpG methylation and its association with neurodegenerative diseases.

  • Multiplexed single-molecule flow-stretching bead assay for DNA enzymology

    Multiplexed single-molecule force spectroscopy. (A) Holographic optical tweezers. (B) Multiplexed magnetic tweezers. (C) Acoustic force spectroscopy.


BMB Reports 2019; 52(10): 577~624
Invited Mini Reviews
A concise review of human brain methylome during aging and neurodegenerative diseases
Renuka Prasad G & Eek-hoon Jho*
BMB Reports 2019; 52(10): 577-588  https://doi.org/10.5483/BMBRep.2019.52.10.215
Multiplexed single-molecule flow-stretching bead assay for DNA enzymology
Ryanggeun Lee, Keunsang Yang & Jong-Bong Lee
BMB Reports 2019; 52(10): 589-594  https://doi.org/10.5483/BMBRep.2019.52.10.170
Articles
Endothelial-specific deletion of Ets-1 attenuates Angiotensin II-induced cardiac fibrosis via suppression of endothelial-to-mesenchymal transition
Lian Xu, Mengxia Fu, Dongrui Chen, Weiqing Han, Michael C. Ostrowski, Paul Grossfeld, Pingjin Gao & Maoqing Ye
BMB Reports 2019; 52(10): 595-600  https://doi.org/10.5483/BMBRep.2019.52.10.206
Deciphering the molecular mechanisms underlying the plasma membrane targeting of PRMT8
Sang-Won Park, Yong-Woo Jun, Ha-Eun Choi, Jin-A Lee & Deok-Jin Jang
BMB Reports 2019; 52(10): 601-606  https://doi.org/10.5483/BMBRep.2019.52.10.272
Ku complex suppresses recombination in the absence of MRX activity during budding yeast meiosis
Hyeseon Yun & Keunpil Kim*
BMB Reports 2019; 52(10): 607-612  https://doi.org/10.5483/BMBRep.2019.52.10.245
Effects of α-lipoic acid on LPS-induced neuroinflammation and NLRP3 inflammasome activation through the regulation of BV-2 microglial cells activation
Su Min Kim, Ji Sun Ha, A Reum Han, Sung-Woo Cho & Seung-Ju Yang
BMB Reports 2019; 52(10): 613-618  https://doi.org/10.5483/BMBRep.2019.52.10.026
Deficiency of calpain-6 inhibits primary ciliogenesis
Bo Hye Kim, Do Yeon Kim, Sumin Oh, Je Yeong Ko, Gyuyeong Rah, Kyung Hyun Yoo* & Jong Hoon Park*
BMB Reports 2019; 52(10): 619-624  https://doi.org/10.5483/BMBRep.2019.52.10.182

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October 2019
Volume 52
Issue 10

2018 SCI Impact Factor 2.966

BIOCHEMISTRY & MOLECULAR BIOLOGY 134/292

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