Fig. 1. Schematic of the ncRNAs transported through the mitochondrial outer and inner membranes (OM, IM). Left, ncRNAs synthesized in mitochondria but found elsewhere (nucleus and extracellular space); right, ncRNAs synthesized in the nucleus and found in mitochondria, including tRNAs, 5S rRNA, lncRNAs like RMRP, and microRNAs and their precursors. Transport factors identified as mediators of these processes, including many ncRNA-interacting RBPs, are indicated. Yellow, nucleus; gray, cytoplasm; blue, mitochondria; pink, extracellular space.
Fig. 2. NMD interacts with cellular processes in different ways: (i) bidirectional interactions in which NMD and a cellular process influence each other (bidirectional arrows); (ii) unidirectional interactions in which NMD influences a cellular process (arrows pointing a cellular process); (iii) unidirectional interactions in which a cellular process regulates NMD efficiency (arrows pointing NMD).
Fig. 1. mRNA processing generates 3’-UTR variants. (A) Schematic depictions of pre-mRNA and mature mRNA. UTR (untranslated region), CDS (protein coding sequence), UC-PAS (upstream core polyadenylation signal), DC-PAS (downstream core polyadenylation signal). (B) mRNA isoforms with alternative poly(A) additions.
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