BMB Rep. 2012; 45(4): 221-226  
Anticoagulant activities of curcumin and its derivative
Dong-Chan Kim1,#, Sae-Kwang Ku2,# & Jong-Sup Bae3,*
1Laboratory of Microvascular Circulation Research, NEUORNEX Inc. Daegu 711-823, 2Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, 3College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 702-701, Korea
Correspondence to: Tel: +82-53-950-8570; Fax: +82-53-950-8557; E-mail: baejs@knu.ac.kr
Received: August 9, 2011; Revised: September 28, 2011; Accepted: October 11, 2011; Published online: April 30, 2012.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

Abstract
Curcumin, a polyphenol responsible for the yellow color of the curry spice turmeric, possesses antiinflammatory, antiproliferative and antiangiogenic activities. However, anticoagulant activities of curcumin have not been studied. Here, the anticoagulant properties of curcumin and its derivative (bisdemethoxycurcumin, BDMC) were determined by monitoring activated partial thromboplastin time (aPTT), prothrombin time (PT) as well as cell-based thrombin and activated factor X (FXa) generation activities. Data showed that curcumin and BDMC prolonged aPTT and PT significantly and inhibited thrombin and FXa activities. They inhibited the generation of thrombin or FXa. In accordance with these anticoagulant activities, curcumin and BDMC showed anticoagulant effect in vivo. Surprisingly, these anticoagulant effects of curcumin were better than those of BDMC indicating that methoxy group in curcumin positively regulated anticoagulant function of curcumin. Therefore, these results suggest that curcumin and BDMC possess antithrombotic activities and daily consumption of the curry spice turmeric might help maintain anticoagulant status.
Keywords: aPTT, Curcumin, HUVECs, PT

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