BMB Rep. 2010; 43(5): 337-343  
Comparative analysis of fat and muscle proteins in fenofibratefed type II diabetic OLETF rats: the fenofibrate-dependent expression of PEBP or C11orf59 protein
Jong Ryeal Hahm1, Jin Sook Ahn2, Hae Sook Noh2, Seon Mi Baek2, Ji Hye Ha2, Tae Sik Jung1, Yong Jun An3, Duk Kyu Kim3 & Deok Ryong Kim2,*
Departments of 1Internal Medicine and 2Biochemistry, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea, 3Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea
Correspondence to: Tel: 82-55-751-8754; Fax: 82-55-758-8005; E-mail:
Received: January 15, 2010; Accepted: March 5, 2010; Published online: May 31, 2010.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

Fenofibrate, an agonist of PPARalpha, plays an important role in activating many proteins catalyzing lipid metabolism, and it also has a considerable effect on improvement of insulin sensitivity in the diabetic condition. To investigate fenofibrate-dependent expression of peripheral tissue proteins in diabetes, we analyzed whole muscle or fat proteins of fenofibrate-fed OLETF rats, an animal model of type II diabetes, using 2-dimensional gel electrophoresis. We found that many proteins were specifically expressed in a fenofibrate-dependent manner in these diabetic rats. In particular, a functionally unknown C11orf59 protein was differentially expressed in the muscle tissues (about 5-fold increase) in fenofibrate-fed OLETF rats as compared to control rats. Additionally, the signal proteins phosphatidylethanolamine binding protein and IkB interacting protein were differentially regulated in the fenofibrate-treated adipose tissues. We suggest here that these proteins might be involved in controlling lipid or carbohydrate metabolism in diabetes via PPARalpha activation.
Keywords: C11orf59, Fenofibrate, OLETF rats, PEBP, PPARα, Proteomics

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