BMB Rep. 2016; 49(9): 514-519  
Analysis of extended haplotype in Korean cattle (Hanwoo) population
Dajeong Lim1, Bong Hwan Choi1, Yong Min Cho1, Han Ha Chai1, Gul Won Jang1, Cedric Gondro2, Yeoung Ho Jeoung3 & Seung Hwan Lee4,*
1Division of Animal Genomics & Bioinformatics, National Institute of Animal Science, RDA, Jeonju 55365, Korea, 2School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia, 3Hanwoo Department, Korea Animal Improvement Association, Seoul 06668, 4Division of Animal and Dairy Science, Chung Nam National University, Daejeon 34134, Korea
Correspondence to: Tel: +82-42-821-5772; Fax: +82-42-825-9754; E-mail: slee46@cnu.ac.kr
Received: April 25, 2016; Revised: May 30, 2016; Accepted: July 27, 2016; Published online: September 30, 2016.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

Abstract
Korean cattle (Hanwoo) are categorized into three breeds based on color: brown, brindle, and black. Among these breeds, brown Hanwoo has been subjected to intensive selection to improve meat traits. To identify genetic traces driven by recent selection in brown Hanwoo, we scanned the genomes of brown and brindle Hanwoo using a bovine SNP chip. We identified 17 candidate selection signatures in brown Hanwoo and sequenced four candidate regions from 10 individuals each of brown and brindle Hanwoo. In particular, non-synonymous SNPs in the ADSL gene (K88M, L189H, and R302Q) might have had mutational effects on protein structure as a result of altering the purine pathway during nucleotide breakdown. The ADSL gene was previously reported to affect meat quality and yield in livestock. Meat quality and yield are main breeding goals for brown Hanwoo, and our results support a potential causal influence of non-synonymous SNPs in the ADSL gene.
Keywords: ADSL, Brindle Hanwoo, Extendend haplotype, Hanwoo


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