BMB Rep. 2016; 49(8): 414-423  
Dual function of MG53 in membrane repair and insulin signaling
Tao Tan1, Young-Gyu Ko2,* & Jianjie Ma1,*

1Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH
43210, USA, 2Division of Life Sciences, Korea University, Seoul 02841, Korea

Correspondence to: Young-Gyu Ko, Tel: +82-2-3290-3453; Fax: +82-2-3290-4144; E-mail:, Jianjie Ma, Tel: +1-614-292-2636; Fax: +1-614-247-7799; E-mail:
Published online: August 31, 2016.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

MG53 is a member of the TRIM-family protein that acts as a key component of the cell membrane repair machinery. MG53 is also an E3-ligase that ubiquinates insulin receptor substrate-1 and controls insulin signaling in skeletal muscle cells. Since its discovery in 2009, research efforts have been devoted to translate this basic discovery into clinical applications in human degenerative and metabolic diseases. This review article highlights the dual function of MG53 in cell membrane repair and insulin signaling, the mechanism that
underlies the control of MG53 function, and the therapeutic value of targeting MG53 function in regenerative medicine.
Keywords: MG53, TRIM72, E3 ligase, Muscular Dystrophy, Membrane Repair, Insulin Resistance

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