BMB Rep. 2016; 49(3): 137-138  
Identification of a neural pathway governing satiety in Drosophila
Soohong Min* & Jongkyeong Chung*
National Creative Research Initiatives Center for Energy Homeostasis Regulation, Institute of Molecular Biology and Genetics and School of Biological Sciences, Seoul National University, Seoul 08826, Korea
Correspondence to: Soohong Min, E-mail: msh2001560011@empas.com, Jongkyeong Chung, E-mail: jkc@snu.ac.kr
Received: March 4, 2016; Published online: March 31, 2016.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

Abstract
Satiety cues a feeding animal to cease further ingestion of food, thus protecting it from excessive energy gain. Impaired control of satiety is often associated with feeding-related disorders such as obesity. In our recent study, we reported the identification of a neural pathway that expresses the myoinhibitory peptide (MIP), critical for satiety responses in Drosophila. Targeted silencing of MIP neuron activity strikingly increased the body weight (BW) through elevated food intake. Similarly, genetic disruption of the gene encoding MIP also elevated feeding and BW. Suppressing the MIP pathway behaviorally transformed the satiated flies to feed similar to the starved ones, with augmented sensitivity to food. Conversely, temporal activation of MIP neuron markedly reduced the food intake and BW, and blunted the sensitivity of the starved flies to food as if they have been satiated. Shortly after termination of MIP neuron activation, the reduced BW reverted to the normal level along with a strong feeding rebound. Together our results reveal the switch-like role of the MIP pathway in feeding regulation by controlling satiety.
Keywords: Anorexigenic pathway, BW, Food intake, MIP, Satiety


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