BMB Rep. 2016; 49(2): 81-92  
The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster
Ozlem Altintas1,#, Sangsoon Park2,# & Seung-Jae V. Lee1,2,3,*
1School of Interdisciplinary Bioscience and Bioengineering, 2Department of Life Sciences, and 3Information Technology Convergence Engineering, Pohang University of Science and Technology, Pohang 37673, Korea
Correspondence to: Tel: +82-54-279-2351; Fax: +82-54-279-2199; E-mail:
Received: December 18, 2015; Published online: February 28, 2016.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. In this review, we describe the mechanisms by which various IIS components regulate aging in C. elegans and D. melanogaster. We also cover systemic and tissue-specific effects of the IIS components on the regulation of lifespan. We further discuss IIS-mediated physiological processes other than aging and their effects on human disease models focusing on C. elegans studies. As both C. elegans and D. melanogaster have been essential for key findings regarding the effects of IIS on organismal aging in general, these invertebrate models will continue to serve as workhorses to help our understanding of mammalian aging.
Keywords: Aging, C. elegans, D. melanogaster, Insulin/IGF-1 signaling, Longevity

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