BMB Reports 2019; 52(2): 109-110
The coordinated regulation of mitochondrial structure and function by Drp1 for mitochondrial quality surveillance
Hyo Min Cho, and Woong Sun*
Department of Anatomy, Korea University College of Medicine, Brain Korea 21 Plus, Seoul 02841, Korea
Correspondence to: *E-mail:
Received: January 20, 2019; Published online: February 28, 2019.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

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Mitochondrial morphology is known to be continuously changing via fusion and fission, but it is unclear what the biological importance of this energy-consuming process is and how it develops. Several data have suggested that mitochondrial fission executed by Drp1 is necessary to select out a damaged spot from the interconnected mitochondrial network, but the precise mechanism for the recognition and isolation of a damaged sub-mitochondrial region during mitochondrial fission is yet unclear. Recently, Cho et al. found that the mitochondrial membrane potential (MMP) is transiently reduced by the physical interaction of Drp1 and mitochondrial Zinc transporter, Zip1, at the fission site prior to the typical mitochondrial division, and we found that this event is essential for a mitochondrial quality surveillance. In this review, Cho et al. discuss the role of a mitochondrial fission in the mitochondrial quality surveillance system.

Keywords: Drp1, Mitochondria, Mitochondrial fission, Mitochondrial membrane potential, Zip1

This research was supported by the National Research Foundation of Korea (NRF-2017M3A9B3061308 and NRF-2018R1A2A3075271).

CCCP: Carbonyl cyanide m-chlorophenylhydrazone
Drp1: Dynamin-related protein 1
DRPs: Dynamin-related proteins
MCU: Mitochondrial calcium uniporter
Mfn1/2: Mitofusin 1/2
MIS: mitochondrial intermembrane space
MMP: Mitochondrial membrane potential
MOM: mitochondrial outer membrane
MPP: Mitochondrial processing peptidase
OPA1: Optic atrophy 1
PARL: Presenilin-associated rhomboid-like protease
PINK1: PTEN-induced putative kinase 1
ROS: Reactive oxygen species
Fig. 1. Schematic illustration for the Drp1-Zip1 interaction-dependent mitochondrial quality surveillance during the mitochondrial fission. Mitochondrial morphology continuously changed by the fusion-fission cycle. (1) Upon stimuli, Drp1 moves to the mitochondria, and interacts with the mitochondrial Zip1 to induce the focal MMP reduction. (2) Drp1 cuts the mitochondria through their oligomerization. (3) Healthy piece of mitochondria recovers their MMP and stays in the fusion-fission cycle, but the damaged mitochondria fail to recover and are subsequently removed by the mitophagy.

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