This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.Mitochondrial morphology is known to be continuously changing via fusion and fission, but it is unclear what the biological importance of this energy-consuming process is and how it develops. Several data have suggested that mitochondrial fission executed by Drp1 is necessary to select out a damaged spot from the interconnected mitochondrial network, but the precise mechanism for the recognition and isolation of a damaged sub-mitochondrial region during mitochondrial fission is yet unclear. Recently, Cho
This research was supported by the National Research Foundation of Korea (NRF-2017M3A9B3061308 and NRF-2018R1A2A3075271).
Fig. 1. Schematic illustration for the Drp1-Zip1 interaction-dependent mitochondrial quality surveillance during the mitochondrial fission. Mitochondrial morphology continuously changed by the fusion-fission cycle. (1) Upon stimuli, Drp1 moves to the mitochondria, and interacts with the mitochondrial Zip1 to induce the focal MMP reduction. (2) Drp1 cuts the mitochondria through their oligomerization. (3) Healthy piece of mitochondria recovers their MMP and stays in the fusion-fission cycle, but the damaged mitochondria fail to recover and are subsequently removed by the mitophagy.
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Funding Information National Research Foundation of Korea National Research Foundation of Korea |
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