BMB Reports 2019; 52(1): 42-46  
Cellular senescence in cancer
Young Hwa Kim & Tae Jun Park*
Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 16499, Korea
Correspondence to: Tel: +82-31-219-5055; Fax: +82-31-219-5059; E-mail: park64@ajou.ac.kr
Received: October 24, 2018; Published online: January 31, 2019.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

Abstract
Cellular senescence, a process of cell proliferation arrest in response to various stressors, has been considered to be important factor in age-related disease. Identification of senescent cells in tissues is limited and the role of senescent cells is poorly understood. Recently however, several studies showed the characterization of senescent cells in various pathologic conditions and the role of senescent cells in disease progression is becoming important. Senescent cells are growth-arrested cells, however, the senescence associated secretory phenotype (SASP) of senescent cells could modify the tissues' microenvironment. Here, we discuss the progress and understanding of the role of senescent cells in tissues of pathologic conditions and discuss the development of new therapeutic paradigms, such as senescent cells-targeted therapy.
Keywords: Cancer, CXCL12, SASP, SA-β-Gal, Senescence
Figures
Fig. 1. Schematic representation of the role of senescent cells in tumors. Senescent cells express SASP and are involved in interactions with the tissue microenvironment, including extracellular matrix (ECM) degradation, immune cells infiltration, and
cancer invasion.


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