BMB Rep. 2015; 48(3): 129-130  
Swapping of interaction partners with ATG5 for autophagosome maturation
Jun Hoe Kim & Hyun Kyu Song*
Division of Life Sciences, Korea University, Seoul 136-713, Korea
Correspondence to: E-mail: hksong@korea.ac.kr
Received: March 19, 2015; Published online: March 31, 2015.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

Abstract
Autophagy is a tightly regulated lysosome-mediated catabolic process in eukaryotes that maintains cellular homeostasis. A distinguishable feature of autophagy is the formation of double- membrane structures, autophagosome, which envelopes the intracellular cargoes and finally degrades them by fusion with lysosomes. So far, many structures of Atg proteins working on the autophagosome formation have been reported, however those involved in autophagosome maturation, a fusion with lysosome, are relatively unknown. One of the molecules in autophagosome maturation, TECPR1, has been identified and recently, structural studies on both ATG5-TECPR1 and ATG5-ATG16L1 complexes revealed that TECPR1 and ATG16L1 share the same binding site on ATG5. These results, in combination with supporting biochemical and cellular biological data, provide an insight into a model for swapping ATG5 partners for autophagosome maturation.
Keywords: ATG5, ATG16L1, Crystal structure, Lysosome fusion, TECPR1


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