BMB Reports 2017; 50(3): 109-110  
Calcium-activated chloride channels: a new target to control the spiking pattern of neurons
Go Eun Ha & Eunji Cheong*
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea
Correspondence to: E-mail:
Received: February 28, 2017; Published online: March 31, 2017.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

The nature of encoded information in neural circuits is determined by neuronal firing patterns and frequencies. This paper discusses the molecular identity and cellular mechanisms of spike-frequency adaptation in the central nervous system (CNS). Spike-frequency adaptation in thalamocortical (TC) and CA1 hippocampal neurons is mediated by the Ca2+-activated Cl- channel (CACC) anoctamin-2 (ANO2). Knockdown of ANO2 in these neurons results in increased number of spikes, in conjunction with significantly reduced spike-frequency adaptation. No study has so far demonstrated that CACCs mediate afterhyperpolarization currents, which result in the modulation of neuronal spike patterns in the CNS. Our study therefore proposes a novel role for ANO2 in spike-frequency adaptation and transmission of information in the brain.
Keywords: Afterhyperpolarization, Anoctamin-2, Calcium-activated chloride channel, Spike-frequency adaptation, Thalamocortical neuron

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