BMB Rep. 2015; 48(1): 1-5  
Physiological functions of the TRPM4 channels via protein interactions
Chang-Hoon Cho1, Young-Sun Lee2,3, Eunju Kim1,2, Eun Mi Hwang2,4,* & Jae-Yong Park1,*
1School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul 136-703, 2Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Seoul 136-791, 3Department of Physiology, Institute of Health Science and Medical Research Center for Neural Dysfunction, Gyeongsang National University School of Medicine, Jinju 660-751, 4Neuroscience Program, University of Science and Technology (UST), Daejeon 305-350, Korea
Received: November 25, 2014; Published online: January 31, 2015.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

Abstract
Transient Receptor Potential, Melastatin-related, member 4 (TRPM4) channels are Ca2+-activated Ca2+-impermeable cation channels. These channels are expressed in various types of mammalian tissues including the brain and are implicated in many diverse physiological and pathophysiological conditions. In the past several years, the trafficking processes and regulatory mechanism of these channels and their interacting proteins have been uncovered. Here in this minireview, we summarize the current understanding of the trafficking mechanism of TRPM4 channels on the plasma membrane as well as heteromeric complex formation via protein interactions. We also describe physiological implications of protein-TRPM4 interactions and suggest TRPM4 channels as therapeutic targets in many related diseases.
Keywords: Glycosylation, Heteromerization, Phosphorylation, SUMOylation, Trafficking, TRPM4, 14-3-3γ


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