BMB Rep. 2016; 49(10): 536-541  
The gut microbiota: a key regulator of metabolic diseases
Jin-Young Yang & Mi-Na Kweon*
Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea
Correspondence to: Tel: +82-2-3010-2096; Fax: +82-2-3010-4234; E-mail: mnkweon@amc.seoul.kr
Received: August 16, 2016; Published online: October 31, 2016.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

Abstract
The prevalence of obesity and type 2 diabetes, two closely linked metabolic disorders, is increasing worldwide. Over the past decade, the connection between these disorders and the microbiota of the gut has become a major focus of biomedical research, with recent studies demonstrating the fundamental role of intestinal microbiota in the regulation and pathogenesis of metabolic disorders. Because of the complexity of the microbiota community, however, the underlying molecular mechanisms by which the gut microbiota is associated with metabolic disorders remain poorly understood. In this review, we summarize recent studies that investigate the role of the microbiota in both human subjects and animal models of disease and discuss relevant therapeutic targets for future research.
Keywords: Gut microbiota, Metabolic disorder, Obesity, Short-chain fatty acids, Type 2 diabetes


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