BMB Rep. 2014; 47(2): 60-68  
The pathophysiological role of dendritic cell subsets in psoriasis
Tae-Gyun Kim1,3, Dae Suk Kim2, Hyoung-Pyo Kim1,* & Min-Geol Lee2,3
1Department of Environmental Medical Biology, Institute of Tropical Medicine, Yonsei University College of Medicine, 2Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, 3Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea
Correspondence to: Tel: +82-2-2228-1842; Fax: +82-2-363-8676; E-mail: kimhp@yuhs.ac
Received: December 30, 2013; Published online: February 28, 2014.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

Abstract
Psoriasis is a chronic inflammatory disorder characterized by an erythematous scaly plaque of the skin and is occasionally accompanied by systemic complications. In the psoriatic lesions, an increased number of cytokine-producing dendritic cells and activated T cells are observed, which indicate that psoriasis is a prototype of an immune-mediated dermatosis. During the last decade, emerging studies demonstrate novel roles for the dendritic cell subsets in the process of disease initiation and maintenance of psoriasis. In addition, recently discovered anti-psoriatic therapies, which specifically target inflammatory cytokines produced by lesional dendritic cells, bring much better clinical improvement compared to conventional treatments. These new therapies implicate the crucial importance of dendritic cells in psoriasis pathogenesis. This review will summarize and discuss the dendritic cell subsets of the human skin and their pathophysiological involvement in psoriasis based on mouse- and patient-oriented studies.
Keywords: Dendritic cells, Psoriasis, Skin


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