BMB Reports 2019; 52(2): 109-110
The coordinated regulation of mitochondrial structure and function by Drp1 for mitochondrial quality surveillance
Hyo Min Cho and Woong Sun*
Department of Anatomy, Korea University College of Medicine, Brain Korea 21 Plus, Seoul 02841, Korea
Correspondence to: *E-mail:
Received: January 20, 2019; Published online: February 28, 2019.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Mitochondrial morphology is known to be continuously changing via fusion and fission, but it is unclear what the biological importance of this energy-consuming process is and how it develops. Several data have suggested that mitochondrial fission executed by Drp1 is necessary to select out a damaged spot from the interconnected mitochondrial network, but the precise mechanism for the recognition and isolation of a damaged sub-mitochondrial region during mitochondrial fission is yet unclear. Recently, Cho et al. found that the mitochondrial membrane potential (MMP) is transiently reduced by the physical interaction of Drp1 and mitochondrial Zinc transporter, Zip1, at the fission site prior to the typical mitochondrial division, and we found that this event is essential for a mitochondrial quality surveillance. In this review, Cho et al. discuss the role of a mitochondrial fission in the mitochondrial quality surveillance system.
Keywords: Drp1, Mitochondria, Mitochondrial fission, Mitochondrial membrane potential, Zip1

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