BMB Reports 2018; 51(9): 456-461  https://doi.org/10.5483/BMBRep.2018.51.9.104
MiR-363 inhibits cisplatin chemoresistance of epithelial ovarian cancer by regulating snail-induced epithelial-mesenchymal transition
Lanqin Cao1, Qian Wan1, Fengjie Li1 & Can-e Tang2,*
1Department of Obstetrics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, 2The Institute of Medical Science Research, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R., China
Correspondence to: Tel: +86-0731-84327628; Fax: +86-731-84327332; E-mail: csutangcane@163.com
Received: May 8, 2018; Revised: May 29, 2018; Accepted: July 20, 2018; Published online: September 30, 2018.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Chemoresistance is a major barrier to successful cisplat-inbased chemotherapy for epithelial ovarian cancer (EOC), and emerging evidences suggest that microRNAs (miRNAs) are involved in the resistance. In this study, it was indicated that miR-363 downregulation was significantly correlated with EOC carcinogenesis and cisplatin resistance. Moreover, miR-363 overexpression could resensitise cisplatin-resistant EOC cells to cisplatin treatment both in vitro and in vivo. In addition, data revealed that EMT inducer Snail was significantly upregulated in cisplatin-resistant EOC cell lines and EOC patients and was a functional target of miR-363 in EOC cells. Furthermore, snail overexpression could significantly attenuate miR-363-suppressed cisplatin resistance of EOC cells, suggesting that miR-363-regulated cisplatin resistance is mediated by snail-induced EMT in EOC cells. Taken together, findings suggest that miR-363 may be a biomarker for predicting responsiveness to cisplatin-based chemotherapy and a potential therapeutic target in EOC.
Keywords: Chemoresistance, Cisplatin, Epithelial-mesenchymal transition, Epithelial ovarian cancer, MiR-363, Snail


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Funding Information
  • Hunan Provincial Science and Technology Department(Department of Science and Technology of Hunan Province)
      10.13039/501100002767
      2017sk2071
  • National Natural Science Foundation of China(NSFC)
      10.13039/501100001809
      81570776

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