BMB Reports 2018; 51(12): 648-653  https://doi.org/10.5483/BMBRep.2018.51.12.205
SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker
Liyun Xu1, Changchang Lu1, Yanyan Huang1, Jihang Zhou1, Xincheng Wang1, Chaowu Liu2, Jun Chen2 and Hanbo Le2,*
1Cell and Molecular Biology Laboratory, Affiliated Zhoushan Hospital of Wenzhou Medical University, Zhoushan 316000, 2Department of Cardio-Thoracic Surgery, Affiliated Zhoushan Hospital of Wenzhou Medical University, Zhoushan 316000, China
Correspondence to: *Corresponding author. Tel: +86-580-2292772; Fax: +86-580-2292518; E-mail: zslehanbo@163.com
Received: September 4, 2018; Revised: October 22, 2018; Accepted: November 15, 2018; Published online: December 31, 2018.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Serine protease inhibitor Kazal type 1 (SPINK1) plays a role in protecting the pancreas against premature activation of trypsinogen and is involved in cancer progression. SPINK1 promoted LAC cells growth, migration, and invasion. Mechanistically, we found that SPINK1 promoted LAC cells migration and invasion via up-regulating matrix metalloproteinase 12 (MMP12). We observed that SPINK1 expression was only up-regulated in lung adenocarcinoma (LAC) tissues, and was an independent prognostic factor for poor survival. Our results indicate that SPINK1 might be a potential biomarker for LAC that promotes progression by MMP12.
Keywords: Biomarker, Cell growth, Lung adenocarcinoma, Metastasis, SPINK1


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