BMB Reports 2018; 51(12): 642-647
UBE2S promotes the proliferation and survival of human lung adenocarcinoma cells
Zhi Liu1,2 and Lijun Xu1,*
1Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun 130021, 2Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao 028000, China
Correspondence to: *Corresponding author. Tel: +86-0431-88782319; Fax: +86-0431-88782320; E-mail:
Received: July 4, 2018; Revised: August 11, 2018; Accepted: October 23, 2018; Published online: December 31, 2018.
© Korean Society for Biochemistry and Molecular Biology. All rights reserved.

cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Ubiquitin-conjugating enzyme E2S (UBE2S), a family of E2 protein in the ubiquitination process, is involved in development of various cancers. However, its role in lung adenocarcinoma, has not been well elucidated. In this report, we attempted to investigate expression and function of UBE2S in lung adenocarcinoma. Up-regulation of UBE2S at mRNA, and protein level, was observed in human cancer tissues and lung adenocarcinoma cells. Higher UBE2S expression correlated with poorer prognosis of lung adenocarcinoma patients. UBE2S expression was efficiently suppressed by lentivirus-mediated shRNA strategy in A549 cells, and UBE2S silencing led to reduced cell proliferation, colony formation, and enhanced apoptosis. Inverse results were observed, in UBE2S over-expressed H1299 cells. Microarray analysis indicated that a large number of genes were regulated by UBE2S, and p53 signaling pathway may be critical, to the role of UBE2S in cancer development. Together, UBE2S could be a potential target for lung adenocarcinoma.
Keywords: Apoptosis, Lung adenocarcinoma, P53, Proliferation, UBE2S

This Article