Applications of CRISPR/Cas9 in HSPCs and B cells. CRISPR/Cas9 can be used to (A) model important pre-disease and disease states such as clonal hematopoiesis of indeterminate potential (CHIP), myelodysplastic syndrome, and acute megakaryoblastic leukemia (AMKL) and (B) to engineer therapeutic cells for the correction or disruption of disease-related genes alongside the introduction of disease-protective genes such as antiviral antibodies in B cells.
