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Fig. 3. Changes in bioactive sphingolipid levels observed during neuroinflammation. Numerous observations in neuroinflammatory environments demonstrate changes in sphingolipid levels. Ceramide is increased in the neurons and glial cells of neuroinflammatory environments. S1P expressed by SphK1 is elevated in the neuroinflammatory environments of glial cells. Neuronal SphK is reduced, regardless of S1P alternations.
BMB Reports 2020;53:28~34 https://doi.org/10.5483/BMBRep.2020.53.1.278
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