BMB Reports : eISSN 1976-670X

Download original image
Fig. 2. Differences between human and rodent TSPO. Unlike the positive correlation between TSPO and neuroinflammation in rodents, TSPO expression in human is not related to inflammation level. Binding partners of TSPO ligands are also different between the two species. For instance, PK11195 has a binding affinity to human CAR but not to mouse CAR.
BMB Reports 2020;53:20~27
© BMB Rep.